Effects of inferior splenic lobe pole fixation and gastrosplenic peritoneal membrane section on the vitality of the remanent of subtotal splenectomy in rats

Mendonça, Fernanda Alves; Carmo, Felipe Poubel Timm do; Paris, Louise Goncalves; Pagotte, Marya Duarte; Pereira, Fernanda Lübe Antunes; Vidigal, Paula Vieira Teixeira; Paulo, Danilo Nagib Salomão; Nunes, Tarcizo Afonso

doi:10.1590/s0102-865020150070000003

Cited by 3 publications

(3 citation statements)

References 25 publications

(28 reference statements)

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“…The results corroborate Paulo et al . 27 , whose findings in the microscopy confirmed the viability of both poles, with the presence of white pulp (lymphoid follicles, and their components), red pulp, vascularity, and cellularity specific to the organ, in addition to possible inflammatory processes.…”

Section: Discussionmentioning

confidence: 66%

“…Mendonça et al . 27 reported that section of the gastrosplenic peritoneal membrane in rats submitted to SSPLP did not change the viability of the LP. A further study with a group of rats using section and other one with no section of the gastroplenic membrane would better clarify the effect of preserving the membrane in the viability of the UP.…”

Section: Discussionmentioning

confidence: 97%

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Study of the upper pole after subtotal splenectomy in rats

et al. 2022

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Purpose: To evaluate macro/microscopic viability of the upper pole (UP) in rats after 80 days of subtotal splenectomy preserving the upper pole (SSPUP). Methods: Twenty-five male Wistar rats were submitted to SSPUP. After 80 days, the rats were euthanized, and the remaining UP was evaluated macroscopically regarding appearance, color, consistency, length, width, thickness, and presence of fibrosis/necrosis; and microscopically regarding presence of red and white pulp, fibrosis/necrosis. Results: Two rats died during surgery and were removed from the statistical analysis. There was statistically significant increase in length and width between the pre and postoperative in the experimental group, with no significant difference in thickness. In the manipulation group, the macroscopic appearance of the spleen was normal in pre and postoperative, with viability preserved. In the experimental group, two UP of the spleen were not found during the second surgery. Macroscopically, it was observed absence of fibrosis and necrosis in all cases. Microscopically, the white and red pulp were intact in both groups. Two spleens of rats in the manipulation group presented areas with fibrosis and necrosis focus, which were not enough to be considered inviable. Conclusions: The UP of the spleen remained viable in 91.3% of the cases.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 97%

Study of the upper pole after subtotal splenectomy in rats

et al. 2022

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“…This may have been due to the lack of initial deficient irrigation to the pole, or it may have been due to the inadvertent section of a thin transparent membrane that joins the stomach to the spleen, which enables the rotation of this segment and consequently the vascular torsion with segmental devascularization. However, in one study, the section of the gastroesplenic peritoneal membrane did not change the viability of the lower pole 15 . However, this result was reported in only one study, requiring posterior confirmation on the influence of the membrane section on the viability of the splenic remnant.…”

Section: Discussionmentioning

confidence: 87%

Macro and microscopic comparison of the upper pole of the spleen with the lower pole in partial splenectomy

et al. 2020

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Purpose To evaluate the viability of the upper (UP) and lower pole (LP) of the spleen from a macro and microscopic point of view, after subtotal splenectomy with preservation (SSP) of the UP and the LP. Methods Seventeen male Wistar rats, two months old, were submitted to SSPUP and SSPLP and 5 to simulated operation (SG). After 80 days, the rats were euthanized, and the remaining LP and UP and intact spleens were evaluated macroscopically and microscopically. Results Two rats died during the operation. Macroscopic analysis showed that in 15 LP, one of them was not viable and in 15 UP and in 5 spleens in the SG, all were viable. In the statistical analysis, there was no difference in relation to viability. The LP and UP analyzed showed variation. As for the length, the UP increased significantly; however, in relation to the width, there was a significant increase in the LP in relation to the UP. In addition, the weight of the UP was significantly greater than that of the LP. Microscopic analysis attested viability of the splenic remnants. Conclusion There was no significant difference regarding the viability of UP and LP, in macroscopy and microscopy.

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Influence of Splenic Implants in the Subcutaneous Tissue on Asplenic Animals Survival

Teixeira

Santiago

Sasaki

et al. 2018

ABCD, arq. bras. cir. dig.

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Background: The best site for splenic implant was not defined, mainly evaluating the functionality of the implant. Aim: To evaluate the effects of autogenous splenic implantation on the subcutaneous tissue in the survival of splenectomized rats. Method: Twenty-one randomly assigned rats were studied in three groups (n=7): group 1 - manipulation of the abdominal cavity and preservation of the spleen; group 2 - total splenectomy; group 3 - splenectomy and implant of the tissue removed in the subcutaneous. The animals were followed for 90 days postoperatively. Results: There was a higher mortality in groups 2 (p=0.0072) and 3 (p=0.0172) in relation to group 1. There was no difference between groups 2 and 3 (p=0.9817). Conclusion: The splenic implant in the subcutaneous is ineffective in the survival of rats submitted to splenectomy.

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Effects of inferior splenic lobe pole fixation and gastrosplenic peritoneal membrane section on the vitality of the remanent of subtotal splenectomy in rats

Cited by 3 publications

References 25 publications

Study of the upper pole after subtotal splenectomy in rats

Study of the upper pole after subtotal splenectomy in rats

Macro and microscopic comparison of the upper pole of the spleen with the lower pole in partial splenectomy

Influence of Splenic Implants in the Subcutaneous Tissue on Asplenic Animals Survival

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