Effect of total splenectomy in the lipid profile in mice

Demuner, Bianca Lacerda; Pinho, Gotardo Zini; Thomaz, João Cunha; Stegmiller, Nataly Pescinalli; Mendes, Roberta Miranda de Araújo; Paulo, Marcela Souza Lima; Paulo, Danilo Nagib Salomão

doi:10.1590/s0102-865020150050000001

Cited by 8 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to these primordial functions, it was demonstrated in an experimental study that the spleen has a role in the lipid metabolism of rats 2 . This result has not been demonstrated in mice 3 .…”

Section: Introductioncontrasting

confidence: 58%

Macro and microscopic comparison of the upper pole of the spleen with the lower pole in partial splenectomy

et al. 2020

Self Cite

View full text Add to dashboard Cite

Purpose To evaluate the viability of the upper (UP) and lower pole (LP) of the spleen from a macro and microscopic point of view, after subtotal splenectomy with preservation (SSP) of the UP and the LP. Methods Seventeen male Wistar rats, two months old, were submitted to SSPUP and SSPLP and 5 to simulated operation (SG). After 80 days, the rats were euthanized, and the remaining LP and UP and intact spleens were evaluated macroscopically and microscopically. Results Two rats died during the operation. Macroscopic analysis showed that in 15 LP, one of them was not viable and in 15 UP and in 5 spleens in the SG, all were viable. In the statistical analysis, there was no difference in relation to viability. The LP and UP analyzed showed variation. As for the length, the UP increased significantly; however, in relation to the width, there was a significant increase in the LP in relation to the UP. In addition, the weight of the UP was significantly greater than that of the LP. Microscopic analysis attested viability of the splenic remnants. Conclusion There was no significant difference regarding the viability of UP and LP, in macroscopy and microscopy.

show abstract

Section: Introductioncontrasting

confidence: 58%

Macro and microscopic comparison of the upper pole of the spleen with the lower pole in partial splenectomy

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Meanwhile, in six other there was no change at all in the lipid profiles (9,(23)(24)(25)(26)(27). However, atherosclerosis was seen more frequently in three of these studies (9,23,24), the incidence did not change in two of them (26,27), and interestingly, atherosclerosis was found less frequently in the study conducted by Li et al (25). Furthermore, Akan (12) and Lemos-Paulo (28) found that all lipid parameters increased after splenectomy, while Akan (12) found that their levels returned to normal with autotransplantation.…”

Section: Discussionmentioning

confidence: 89%

“…In another study by Altinel et al, LDL, oxLDL, and TG were all found to be high (22). Meanwhile, in six other there was no change at all in the lipid profiles (9,(23)(24)(25)(26)(27). However, atherosclerosis was seen more frequently in three of these studies (9,23,24), the incidence did not change in two of them (26,27), and interestingly, atherosclerosis was found less frequently in the study conducted by Li et al (25).…”

Section: Discussionmentioning

confidence: 89%

The impact of splenectomy on human lipid metabolism

Güneş¹,

Turgut

Bağ

et al. 2022

ujms

View full text Add to dashboard Cite

Background: Splenectomy impacts hematological, immunological, and metabolic functions of the patient. Since our understanding of its metabolic effects, in particular effects on lipid metabolism, is limited, this study aims to investigate the effects of splenectomy on lipid metabolism. Methods: The data from 316 patients undergoing splenectomy between 2009 and 2019 were retrospectively analyzed. Thirty-eight patients whose serum lipid values were measured both preoperatively and 1 year after surgery were included in this study. Results: Significantly higher levels of total cholesterol, low-density lipoprotein (LDL), and non-high-density lipoprotein (HDL) lipid profile were found in the postsplenectomy measurements. However, no significant differences were recorded in levels of triglyceride, HDL, or very-LDL. Conclusion: We determined that splenectomy does impact lipid metabolism, and that the metabolic effects of splenectomy should further be investigated.

show abstract

“…The spleen is an essential organ of the hematological system since the embryonic phase, and it is the main responsible for the acute defense against the invasion of microorganisms, including bacteria, fungi and viruses 1 , 3 , 4 . It is also related to lipid metabolism and is responsible for part of the functions attributed to the liver, such as the production of bilirubins and amino acids 20 – 22 . On the other hand, the asplenic state is related to a high incidence of sepsis, pulmonary embolism, increased peripheral insulin resistance and dyslipidemia, associated with early death 1 , 3 , 4 , 23 .…”

Section: Discussionmentioning

confidence: 99%

Splenectomy is associated with sexual dysfunctions and decreased libido

Sabino

Petroianu

2021

Sci Rep

View full text Add to dashboard Cite

The removal of the spleen due to disease or trauma may be followed by disorders due to the asplenism, including immunodeficiency, hematological and metabolic diseases, mainly dyslipidemia, which can lead to sepsis, pulmonary embolism and early death. Although patients frequently report sexual disinterest after splenectomy, this feature has been experimentally studied only in a translational investigation performed by the same group of this work. To study libido and other sexual functions after the complete removal of the spleen in humans. This study was performed on 60 healthy adults, 30 men and 30 women, after more than 1 year of total splenectomy to treat isolated splenic trauma. The International Index of Erectile Function was applied to men and the Female Sexual Function Index to women. The analysis compared the responses obtained in the periods before and after the splenectomy. Laboratory tests with hematological and biochemical analyses, including sex hormones, were performed in all patients. The pre- and postoperative results were compared in each group using the paired t-test, with each patient being his or her own control and with significance to p < 0.05. A decrease in libido and an increase in sexual dysfunction was observed after splenectomy in all men and women, p < 0.001. All postoperative laboratory tests showed normal values in both genders. Asplenia is associated with a marked decrease in libido and intense sexual dysfunction in both men and women, with normal hematological and biochemical laboratory tests, including hormonal exams.

show abstract

Effect of total splenectomy in the lipid profile in mice

Cited by 8 publications

References 22 publications

Macro and microscopic comparison of the upper pole of the spleen with the lower pole in partial splenectomy

Macro and microscopic comparison of the upper pole of the spleen with the lower pole in partial splenectomy

The impact of splenectomy on human lipid metabolism

Splenectomy is associated with sexual dysfunctions and decreased libido

Contact Info

Product

Resources

About