Copaiba oil effect on experimental jaw defect in Wistar rats

Silva, Priscilla Flores; Brito, Marcus Vinicius Henriques; Pontes, Flávia Sirotheau Corrêa; Ramos, Suzana Rodrigues; Mendes, Laís Cordeiro; Oliveira, Louize Caroline Marques

doi:10.1590/s0102-86502015002000006

Cited by 4 publications

(16 citation statements)

References 20 publications

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“…The oral administration of copaiba has been used as another form of alternative therapy with controversial results. With 28.6%, in the present meta-analysis, the oral administration of copaiba has been shown to be an effective agent against certain parasites, 14 gastrointestinal cancer, 8 6,7,15 arthritis, 16 and other conditions. Contrary to what was thought, the oral administration of copaiba was shown to be non-toxic to rat liver when used as a carrier for amphotericin B.…”

Section: Resultsmentioning

confidence: 72%

“…These differences in toxicity reported in the use of copaiba oil were even more evident when Teixeira et al 1 demonstrated that 200 mg/kg/day presented low toxicity and positive results in inflammatory processes. Similarly, Silva et al 6,7 demonstrated that 50 μg/mL of nanocomposite system (Nano COR) was developed and a toxicity test was performed. The tests showed that Nano COR has a greater impact on the behavior of human endometriotic stromal cells than on the behavior of eutopic endometrium stromal cells, supporting the idea that Nano COR, a form of copaiba oil, should be further investigated as a novel and valuable alternative to treat endometriosis.…”

Section: Resultsmentioning

confidence: 99%

“…3 Another component from copaiba oil with potent antioxidant and anti-inflammatory properties is kaurenoic acid. 6,7 According to Silva et al 16 , the results of their research demonstrated a significant decrease in tumor necrosis factor α (TNF-α) and Interleukin-1 (IL-1) expression and myeloperoxidase (MPO) activity at the T1/T2 time point.…”

Section: Resultsmentioning

confidence: 99%

“…4 Other, newer studies are being performed to find other forms of administration. 6,7 In vitro experiments have shown direct damage to the DNA of cancerous stomach cells with the administration of copaiba oil. The responsible agent in copaiba oil was found to be kaurenoic acid.…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

et al. 2018

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Recent studies demonstrated that one of the major components of the copaiba oil, β-caryophyllene, has an anti-inflammatory effect. 4 Copaiba oil is extracted from the copaifera, a Abstract Many medicinal plants are sought as alternative therapies for various conditions, as opposed to synthetic alternatives. The Brazilian Amazon provides a plethora of plants with various therapeutic and medicinal properties. One of them is copaiba oil, a natural product of the biodiversity of the Amazon. The anti-inflammatory and antimicrobial properties of copaiba oil have been drawing the attention of the scientific community as a great alternative in the treatment of illnesses associated with inflammatory and infectious processes. The purpose of the present study is to evaluate and analyze the latest publications on the use of copaiba oil in the PubMed/Medline database from 2014 to 2017. Forty-two articles were collected, verifying anti-inflammatory activity, antimicrobial activity, healing, and antitumor activity. The results found on researches with copaiba oil according to publication dates were 11.9% in 2014, 38.1% in 2015, 16.7% in 2016, and 33.3% in 2017. In the analyzed studies, the proposed administration of copaiba oil was 50% topical, 28.6% oral, 9.5% enteral, 4.8% subcutaneous, and 7.1% others. In the objectives of the presente study in relation to the administration of copaiba oil, the result was 31% antimicrobial, 28.6% anti-inflammatory, 9.5% antitumor, 9.5% healing, and 21% others. Regarding the types of research, we have found 50% in vitro, 40.4% in vivo animals, 2.4% in vivo human, 2.4% review and 4.8% others. Regarding the significance factor evaluation, the result was 100% positive in antitumor activity, 84% positive in infection and inflammation pathology, 62% positive in others, like dental processes, food technology application support and as a drug absorption vehicle, and 50% in healing. The results presented in the current meta-analysis show that copaiba oil is an effective alternative to treatments of illnesses such as chronic inflammation, infectious diseases, various types of cancer, autoimmune diseases, and as a vehicle for the absorption of other drugs. Thus, more studies regarding the benefits of copaiba oil could provide a great contribution to the medical community in the treatment of the aforementioned illnesses.

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Section: Resultsmentioning

confidence: 72%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

et al. 2018

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“…Atualmente, nenhum material capeador disponível comercialmente preenche todos os requisitos para um resultado de sucesso, apesar do progresso rápido neste campo (Dominguez et al, 2003;Accorinte et al, 2008;Parirokh et al, 2011;Silva et al, 2015), necessitando de inúmeros estudos para este fim. Assim, é importante ter conhecimento dos potenciais efeitos benéficos da relação entre os materiais de capeamento pulpar direto com o complexo dentino-pulpar para obter resultados mais satisfatórios (Ferracane et al, 2010 (Schroder, 1985;Mohammadi;Dummer, 2011).…”

Section: Capeamento Pulparunclassified

Análise do efeito da aplicação direta de materiais capeadores à base de óleo de copaíba sobre a polpa de molares murinos

Lima¹

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This translational study evaluated the effect of the direct application of copaiba oil based capping materials on the rat pulp. The biomaterial was analyzed according to inflammatory, repairing and regenerative processes. Class I cavities were prepared on the occlusal surface of the upper and lower molars of Wistar rats (n = 120). Subsequently, standardized cavities was performed with ¼ spherical carbide drill. Pulp exposures were obtained and after their hemostasis with sterile cotton and distilled water, pulp capping was done with application of biomaterials directly on the pulp tissue. The biomaterials used were: COP (Copaíba oil); Ca(OH)2 (calcium hydroxide), Ca(OH)2+COP; MTA (aggregate mineral trioxide); MTA+COP; BIODENTINE (Biodentine®); BIODENTINA+COP. All cavities were restored with temporary cement. The animals were sacrificed after the period of 7, 14, 28 days according to the principles of ethics and animal experimentation. Twenty-one groups were created from the combination of times and materials, each group consisted of 5 animals. The specimens were prepared and processed by histological technique and stained by HE (haemotoxin and eosin); randomized cuts were examined under optical microscope with 100X enlargement by two different examiners. The evaluated criteria were inflammatory and degenerative response, tissue organization, reactive and reparative dentin. In the last experimental period (28 days) of all groups, the surface (mm 2) and the volume (mm 3) of the reactive and reparative dentin formed were analyzed by the high-resolution micro-CT (computerized microtomography) technique. The data were statistically analyzed using the paired T-test, determining the surface and volume of the reparative dentin formed between the experimental groups. In the histological analyzes, the non-parametric Mann-Whitney test was used, comparing groups (α = 5%). BIODENTINE demonstrated a tendency to accelerate the process of pulpal regeneration, initiating the deposition of reparative dentin on the seventh day of the capping. This material had a thicker dentin compared to the other biomaterials. The MTA also demonstrated an efficiency in the formation of the dentin bridge; however, 20% of the samples did not observe the presence of reparative dentin. When adding the COP in these materials, the formation of the dentin bridge was heterogeneous and incomplete, in addition these groups contained an increased inflammatory process. The repair dentin of the Ca(OH)2 group showed a tunnel with a heterogeneous characteristic. The addition of COP to Ca(OH)2 increased dentin formation in the walls around the pulp chamber in 80% of the samples, but this dentin did not show improvement in quality. Thus, pulp cap with COP isolated or associated with Ca(OH)2, MTA and BIODENTINE did not form a complete and homogeneous dentin bridge at the site of pulp exposure.

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Anti-inflammatory and wound healing effect of Copaiba oleoresin on the oral cavity: A systematic review

Menezes

Alves

Goldemberg

et al. 2022

Heliyon

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Copaiba oil effect on experimental jaw defect in Wistar rats

Cited by 4 publications

References 20 publications

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

Análise do efeito da aplicação direta de materiais capeadores à base de óleo de copaíba sobre a polpa de molares murinos

Anti-inflammatory and wound healing effect of Copaiba oleoresin on the oral cavity: A systematic review

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