2015
DOI: 10.1590/s0102-86502015002000003
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: PURPOSE:To evaluate which is the best route of administration for cell therapy in experimental rat model of small-for size syndrome. METHODS:A total of 40 rats underwent partial hepatectomy (70%) that induces the small-for-size syndrome and were divided into four groups of route administration: intravenous, intraperitoneal, enteral and tracheal. The small-for-size syndrome model was designed with extended partial hepatectomy (70%). The animals were divided into four groups of routes administration: intravenous… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
5
0

Year Published

2016
2016
2022
2022

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 7 publications
(5 citation statements)
references
References 8 publications
(12 reference statements)
0
5
0
Order By: Relevance
“…The extended hepatectomy with the resection volume between 70% and 90% in rats is most widely used to model SFSS following either extended hepatectomy or reduced-size liver transplantation (Nacif et al 2015; Dahmen et al 2008; Wakabayashi et al 2021). Based on our previous study, 80% hepatectomy compromises liver function in rats without conferring mortality risk compared with 90% hepatectomy (Shi et al 2011).…”
Section: Methodsmentioning
confidence: 99%
“…The extended hepatectomy with the resection volume between 70% and 90% in rats is most widely used to model SFSS following either extended hepatectomy or reduced-size liver transplantation (Nacif et al 2015; Dahmen et al 2008; Wakabayashi et al 2021). Based on our previous study, 80% hepatectomy compromises liver function in rats without conferring mortality risk compared with 90% hepatectomy (Shi et al 2011).…”
Section: Methodsmentioning
confidence: 99%
“…Systemic transmission uses vascular pathways, such as intravenous (IV) and intra-arterial (IA) methods. According to the publications in the literature, IV is the most common method, followed by intrasplenic and IP [ 85 , 86 , 87 ]. In a liver disease model, IV was shown to be not only suitable for targeting the liver, but also showed better liver regeneration effects than other routes of administration [ 85 , 88 ].…”
Section: From Preclinical Study To Clinical Trialmentioning
confidence: 99%
“…According to the publications in the literature, IV is the most common method, followed by intrasplenic and IP [ 85 , 86 , 87 ]. In a liver disease model, IV was shown to be not only suitable for targeting the liver, but also showed better liver regeneration effects than other routes of administration [ 85 , 88 ]. Intracardial injection showed better cell retention in heart disease, while intradermal injection showed better treatment in skin diseases [ 89 , 90 ].…”
Section: From Preclinical Study To Clinical Trialmentioning
confidence: 99%
“…The extended hepatectomy with the resection volume between 70% and 90% in rats is most widely used to model SFSS following either extended hepatectomy or reduced-size liver transplantation [13][14][15]. Based on our previous study, 80% hepatectomy compromises liver function in rats without conferring mortality risk compared with 90% hepatectomy [16].…”
Section: Development Of Partial Hepatectomy In Ratsmentioning
confidence: 99%