Combined polyglycolic acid tube and autografting versus autografting or polyglycolic acid tube alone. A comparative study of peripheral nerve regeneration in rats

Abstract

PURPOSE:To compare sciatic nerve regeneration in rats using three different techniques of repair. METHODS:Fifteen isogonics rats were divided into three groups according to the method used to repair a 5-mm long defect created in the sciatic nerve: autogenous graft (Group A), polyglycolic acid tube (PGAt) (Group B), and of the association of PGAt with the graft (Group C). Histological analysis, regenerated myelinated axon number count and functional analysis were used to compare after six weeks. RESULTS:There was no difference in fiber diameter and degree of myelinization presented by Groups A, B and C. Group B presented the lowest number of regenerated axons. The groups did not display any significant functional difference after walking track analysis (p<0.05). CONCLUSION:No differences between the three groups in terms of functional recovery, although there were histological differences among them.

Olfactory Derived Stem Cells Delivered in a Biphasic Conduit Promote Peripheral Nerve Repair In Vivo

“…In terms of the current state of the art, there are typically two approaches to peripheral nerve regeneration: cell‐free tissue‐engineered nerve grafts and cell based therapeutic approaches. Taking the carrier in isolation, morphologically, the cell free NGC performed well in comparison to recent studies over similar defect distances on other biomaterials . The axons generated by the NGC in this study gave better results in terms of total axon count (NGC gave a mean axon count of 4,671 compared to Costas reported 4,225.2 or de Ruiters reported 2,925 for a PGLA multichannel tube) and critically, axonal calibre (3.6 µm compared to de Ruiters 4.01).…”

Stem Cell Technology in Peripheral Nerve Restoration

“…Багато біоматеріалів випробовувалося у експериментах [42], найбільш обнадійливі результати були досягнуті за допомогою полігліколевої кислоти (ПГК). Була показана здатність полігліколевих трубок покращувати регенерацію ПН при його критичних дефектах, як у експерименті [43], так і у клініці [44].…”

Comparisons of the results of peripheral nerve defect repair with fibrin conduit and autologous nerve graft: An experimental study in rats

“…However, it has been observed that compression syndromes often occur due to the non‐degradable nature of the material . Synthetic conduits built from absorbable materials such as polyglycolic acid and poly‐3‐hydroxybutyrate (PHB) have also been tested and had results similar to those of the standard autograft treatment . However, there is still no biological or synthetic conduit available for clinical use that has the same regenerative capacity as an autologous nerve graft.…”