Biomodulation effects of LED and therapeutic ultrasound combined with semipermeable dressing in the repair process of cutaneous lesions in rats

Abstract

PURPOSE:To compare the biomodulatory effects of LED and ultrasound combined with semipermeable dressing in the repair of cutaneous lesions. METHODS:Eighty-four Wistar rats were submitted to surgical injury (2.5 cm) and divided into four groups (n=21): Group I (control), Group II (LED therapy, LED), Group III (LED therapy + dressing, LED+D) and Group IV (ultrasound + dressing, US+D). At seven, 14 and 21 days, the animals were euthanized, and the specimens of interest removed for histological analysis. RESULTS:Histological and histomorphometric analysis revealed a greater percent wound regression in animals receiving the dressing (group III: 55.97; group IV: 53.06), as well as a greater reduction in the inflammatory infiltrate (group III: 29.14; group IV: 31.71) since day 7. A later effect, with progression of the tissue repair process only after 14 and 21 days, was observed in the LED group intense fibroblast proliferation and greater collagen fiber production and organization were seen in the LED+D and US+D groups compared to the other groups.CONCLUSION: LED combined with a dressing was more effective at accelerating in the repair of cutaneous lesions.

630 nm Light Emitting Diode Irradiation Improves Dermal Wound Healing in Rats

“…Several studies have been reported that 630 nm and 640 nm LED irradia-tion with 4-24 J/cm 2 decreased wound surface area. 10,[15][16][17] Our results agree with the findings from several other studies that used 640 nm and 700 nm LED with 15-16 J/cm 2 to stimulate fibroblast proliferation and collagen production on excision wound in rats. 16,18,19 In the present study, epithelial gap of LED group showed signifi-…”

Parameter Search to Find Ranges of Activation and Inhibition of Wound Healing Rate in a Mathematical Model with Introduced Photobiomodulation

“…Thus, the activation increase towards a maximum is not represented. Lastly, the light doses, irradiation parameters, and experimental models are not similar [4,5,6,7,8].…”

“…Five papers in total were used, reporting changes in cell proliferation upon light stimulation, and is documented within Tab. 3 [4,5,6,7,8].…”

Efeitos fotobiomoduladores das luzes vermelha, azul e verde sobre o colágeno durante o processo de cicatrização de queimaduras cutâneas: uma revisão integrativa

“…Neste sentido, destaca-se o uso fototerapia LED (Light Emiting Diodes) com comprimento de onda que varia e 405nm (azul) a 940nm (infravermelho) em uma variedade de situações clínicas pela ativação precoce da fase inflamatória, aumentando significativamente a proliferação dos fibroblastos e redução do infiltrado inflamatório (Nogueira et al, 2014;Meyer et al, 2010).…”