Effect of exercise on the maternal outcome in pregnancy of spontaneously hypertensive rats

Rocha, Rosilene Fernandes da; Peraçoli, José Carlos; Volpato, Gustavo Tadeu; Damasceno, Débora Cristina; Campos, Kleber Eduardo de

doi:10.1590/s0102-8650201400150002

Cited by 9 publications

(4 citation statements)

References 41 publications

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“…Our results also showed a lower rate of macrosomic offspring (LPA). Human studies show that exercise during pregnancy may be associated with changes in newborn weight at birth, either reduced weight [25,26] or increased weight [27]. Regular exercise during pregnancy may elicit maternal and fetal adaptations with the potential for either positive or negative long-term effects on offspring.…”

Section: Discussionmentioning

confidence: 99%

Small-for-pregnancy-age rats submitted to exercise: DNA damage in mothers and newborns, measured by the comet assay

Netto

Gelaleti

Corvino

et al. 2018

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Fetal impairment caused by a deleterious intrauterine environment may have long-term consequences, such as oxidative stress and genetic damage. Rats born as small-for-gestational-age (SPA) were submitted to exercise (swimming) before and during pregnancy. The animals exhibited glucose intolerance, reduced general adiposity, and increased maternal and offspring organ weight, showing the benefit of exercise for these rats. We hypothesised that regular exercise in SPA during gestation could prevent DNA damage in these animals and in their offspring, contributing to altered fetal programming of metabolism in the offspring. Severe diabetes was induced by streptozotocin treatment, to obtain SPA newborns. At adulthood, pregnant SPA rats were randomly distributed into two groups: exercised (SPAex - submitted to swimming program) or not-exercised (SPA - sedentary rats). Post-partum, blood was collected for analysis of DNA damage (comet assay) and oxidative stress. SPAex rats presented lower DNA damage levels, decreased lipid peroxidation, and a lower rate of newborns classified as large-for-pregnancy-age. DNA damage was also lower in SPAex newborns. We conclude that swimming applied to SPA pregnant rats contributes to decreased DNA damage and lipid peroxidation in the dams, and decreased DNA damage and macrosomia in their offspring.

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Section: Discussionmentioning

confidence: 99%

Small-for-pregnancy-age rats submitted to exercise: DNA damage in mothers and newborns, measured by the comet assay

Netto

Gelaleti

Corvino

et al. 2018

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…Our data align with previous studies revealing that voluntary exercise ameliorates poor fetal growth [ 35 , 36 ]. However, work from Rocha and colleagues revealed that maternal exercise (swimming) did not increase fetal weight in spontaneously hypertensive (SHR) rats [ 38 ]. In contrast to our model, in that study, rats began exercise (20 minutes of daily swimming initially; increased gradually to one hour per day until GD 20) on GD 7 and exercise promoted (rather than attenuated) FGR when compared with sedentary control rats [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, work from Rocha and colleagues revealed that maternal exercise (swimming) did not increase fetal weight in spontaneously hypertensive (SHR) rats [ 38 ]. In contrast to our model, in that study, rats began exercise (20 minutes of daily swimming initially; increased gradually to one hour per day until GD 20) on GD 7 and exercise promoted (rather than attenuated) FGR when compared with sedentary control rats [ 38 ]. Whereas these data suggest that exercise initiated during an established pregnancy may be detrimental as a result of increased maternal physiological demands and cardiovascular overload [ 36 ], our current study reveals that exercise initiated prior to pregnancy and consistently maintained throughout gestation may be beneficial.…”

Section: Discussionmentioning

confidence: 99%

Moderate Exercise Attenuates Lipopolysaccharide-Induced Inflammation and Associated Maternal and Fetal Morbidities in Pregnant Rats

et al. 2016

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Fetal growth restriction (FGR) and coagulopathies are often associated with aberrant maternal inflammation. Moderate-intensity exercise during pregnancy has been shown to increase utero-placental blood flow and to enhance fetal nutrition as well as fetal and placental growth. Furthermore, exercise is known to reduce inflammation. To evaluate the effect of moderate-intensity exercise on inflammation associated with the development of maternal coagulopathies and FGR, Wistar rats were subjected to an exercise regime before and during pregnancy. To model inflammation-induced FGR, pregnant rats were administered daily intraperitoneal injections of E. coli lipopolysaccharide (LPS) on gestational days (GD) 13.5–16.5 and sacrificed at GD 17.5. Control rats were injected with saline. Maternal hemostasis was assessed by thromboelastography. Moderate-intensity exercise prevented LPS-mediated increases in white blood cell counts measured on GD 17.5 and improved maternal hemostasis profiles. Importantly, our data reveal that exercise prevented LPS-induced FGR. Moderate-intensity exercise initiated before and maintained during pregnancy may decrease the severity of maternal and perinatal complications associated with abnormal maternal inflammation.

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“…The mating period consisted of 15 consecutive days, a period comprising approximately three estral cycles, until a replicate number was obtained. However, during this period, nonmated female rats were considered to be infertile and were discarded from the study 9 .…”

Section: Mating and Pregnancymentioning

confidence: 99%

Physiological and biochemical measurements before, during and after pregnancy of healthy rats

et al. 2015

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PURPOSE:To analyze the physiological and biochemical measurements before, during and after pregnancy of healthy rats. METHODS:Wistar adult females rats (n=8) were weighed and blood samples were obtained before, during and after pregnancy for biochemical determinations, chow intake, water consumption and milk production were evaluated. At day 10 postpartum, the rats were killed for weighing of organs and adipose tissues. RESULTS:The results showed increase in body weight, serum insulin and ingestion of water and chow. At day 17 pregnancy, presented normal values in the OGTT. At days 7, 14 and 20 of pregnancy, there was increase in triglyceride levels. At term pregnancy, there was weight gain due to fetal growth. In the postpartum period presented reduced blood glucose levels. The glycemic means were reduced during and after pregnancy compared to after pregnancy. The triglyceride concentrations were increased before and during pregnancy in relation to after pregnancy. The total cholesterol levels presented no changes. CONCLUSION:The use of experimental animals is suitable for evaluation of metabolic changes because the profile of answers found in this study was similar to human profile, showing the relevance of translational research to better understand the pathophysiological mechanisms and possible treatment for diseases.

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Effect of exercise on the maternal outcome in pregnancy of spontaneously hypertensive rats

Cited by 9 publications

References 41 publications

Small-for-pregnancy-age rats submitted to exercise: DNA damage in mothers and newborns, measured by the comet assay

Small-for-pregnancy-age rats submitted to exercise: DNA damage in mothers and newborns, measured by the comet assay

Moderate Exercise Attenuates Lipopolysaccharide-Induced Inflammation and Associated Maternal and Fetal Morbidities in Pregnant Rats

Physiological and biochemical measurements before, during and after pregnancy of healthy rats

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