2014
DOI: 10.1590/s0102-86502014001300007
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: PURPOSE:To analyze Pten and Smad4 gene expression in the urogenital system of Wistar rats in differents ages. METHODS:Pten and Smad4 mRNA expression was assessed in the bladder, ventral prostate, testis, ovaries, and uterus by real-time PCR. Statistical analysis using the ANOVA (p<0.05). RESULTS:Pten levels showed a progressive age-dependent increase in the bladder (male and female) and prostate and were elevated in the ovaries of the middle-aged. In the uterus, no statistically significant differences were ob… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2017
2017
2021
2021

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(1 citation statement)
references
References 21 publications
(19 reference statements)
0
1
0
Order By: Relevance
“… 39 In mice, SMAD4 and PTEN synergistically inhibit the fore-stomach squamous cell carcinoma, and mutations in them enhance the cell growth and carcinogenesis. 40 , 41 In addition, the MH2 domain is more frequently mutated than the MH1 domain or the linker region. It is reported that the MH2 domain is a mutation hotspot region in SMAD4.…”
Section: Mutations That Affect the Functions Of Smad4 Proteinmentioning
confidence: 99%
“… 39 In mice, SMAD4 and PTEN synergistically inhibit the fore-stomach squamous cell carcinoma, and mutations in them enhance the cell growth and carcinogenesis. 40 , 41 In addition, the MH2 domain is more frequently mutated than the MH1 domain or the linker region. It is reported that the MH2 domain is a mutation hotspot region in SMAD4.…”
Section: Mutations That Affect the Functions Of Smad4 Proteinmentioning
confidence: 99%