2014
DOI: 10.1590/s0102-86502014000400009
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Abstract: Brazil. Design the protocol, final approval of the version to be published. ABSTRACT PURPOSE:To evaluate the effect of diabetes mellitus and of sildenafil citrate on female urethral function. METHODS:Twenty nine female rats were divided into four groups: G1 -(n=9), normal rats; G2 -(n=6), normal rats treated with sildenafil citrate; G3 -(n=9) rats with alloxan-induced diabetes; G4 -(n=5) rats with alloxan-induced diabetes treated with sildenafil citrate. Under anesthesia, urodynamic evaluation was performed by… Show more

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Cited by 3 publications
(2 citation statements)
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“…These changes can increase outlet resistance, leading to bladder remodeling and accommodation of larger postvoid residual volume (which can ultimately lead to urine reflux and damage to the upper urinary tract), thereby exacerbating the impact of impaired bladder contractility in diabetic bladder dysfunction (DBD) (129). Recent studies also found a significant increase in urethral pressure during micturition in alloxan-induced female diabetic rats (42,86). Chen et al (20) suggested the increase in the expression of ␣ 1 -adrenoceptor and the impairment of the nerve growth factor (NGF) pathway in the urethras may be involved in diabetic urethral dysfunction.…”
Section: T1dm and Ucodmentioning
confidence: 99%
“…These changes can increase outlet resistance, leading to bladder remodeling and accommodation of larger postvoid residual volume (which can ultimately lead to urine reflux and damage to the upper urinary tract), thereby exacerbating the impact of impaired bladder contractility in diabetic bladder dysfunction (DBD) (129). Recent studies also found a significant increase in urethral pressure during micturition in alloxan-induced female diabetic rats (42,86). Chen et al (20) suggested the increase in the expression of ␣ 1 -adrenoceptor and the impairment of the nerve growth factor (NGF) pathway in the urethras may be involved in diabetic urethral dysfunction.…”
Section: T1dm and Ucodmentioning
confidence: 99%
“…26 In cystomanometric studies in diabetic female rats, sildenafil partially reduced urethral pressure. 27…”
mentioning
confidence: 99%