Oxidative stress and fatty acid profile in Wistar rats subjected to acute food restriction and refeeding with high-fat diets

Nassar, Ana Lígia da Silva; Marot, Luisa Pereira; Ovídio, Paula Payão; Castro, Gabriela Salim de; Júnior, Alceu Afonso Jordão

doi:10.1590/s0102-86502014000300006

Cited by 10 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidative stress plays a critical role in hepatic fat deposition induced by an HFD [41,42], and has a link to translational regulation [43,44], which was also seen in our analysis. Hence, translational regulation might be associated with HFD-induced fat deposition in the liver.…”

Section: Rnc-seq Performed On the Livers Of Hfd Plus Lyc-fed Micesupporting

confidence: 79%

Comprehensive analysis of the translatome reveals the relationship between the translational and transcriptional control in high fat diet-induced liver steatosis

Luo

Liu

et al. 2020

RNA Biology

View full text Add to dashboard Cite

Translational regulation plays a critical role in gene expression. However, there are few genome-wide studies on translational regulation in non-alcoholic fatty liver disease (NAFLD), which is a severe noncommunicable epidemic worldwide. In this study, we performed RNC-mRNA (mRNAs bound to ribosome-nascent chain complex) sequencing and mRNA sequencing to probe the translation status of high-fat-diet (HFD) induced mouse fatty liver. Generally, in the HFD group compared to the control group, changes of translation ratios and changes in mRNA abundance had a negative correlation. The relative abundance of RNC-mRNAs and mRNAs were positively correlated, yet the former changed more slowly than the latter. However, the rate of change became more balanced when it came to the livers of mice that were fed the HFD plus lycopene, an antioxidant. This indicated relatively independent roles of translational modulation and transcriptional regulation. Furthermore, many genes were differentially regulated at the transcriptional or translational levels, suggesting a new screening strategy for functional genes. In conclusion, our analysis revealed the different and correlated role of translational control with transcriptional regulation in the HFD-induced mouse fatty liver relative to the control, which indicates critical roles of translational control for liver steatosis; thus, adding a new dimension towards a better understanding and improvement of treatment for NAFLD.

show abstract

Section: Rnc-seq Performed On the Livers Of Hfd Plus Lyc-fed Micesupporting

confidence: 79%

Comprehensive analysis of the translatome reveals the relationship between the translational and transcriptional control in high fat diet-induced liver steatosis

Luo

Liu

et al. 2020

RNA Biology

View full text Add to dashboard Cite

show abstract

“…Furthermore, in large and long term intervention trials such as Prevención con Dieta Mediterránea (PREDIMED), the weight differences did not entirely explain the observed differences in inflammatory biomarkers . Second, the relation between plant‐based diets and changes in inflammatory biomarkers may also be related to coinciding changes in the levels of oxidative stress that are being reduced in diets lower in saturated fatty acids and richer in polyunsaturated fatty acids . Third, based on evidence from cross‐sectional population studies and a meta‐analysis of intervention trials, diets with a high glycemic load were shown to adversely affect inflammatory markers, therefore another explanation could include reduced levels of circulating glucose after plant based interventions .…”

Section: Discussionmentioning

confidence: 99%

Effect of plant‐based diets on obesity‐related inflammatory profiles: a systematic review and meta‐analysis of intervention trials

et al. 2016

View full text Add to dashboard Cite

Plant-based dietary interventions have been proposed to reduce obesity induced chronic low-grade inflammation and hence prevent chronic disease risk; however, human evidence remains unclear. This systematic review and meta-analysis of intervention trials aimed to assess the effect of plant-based diets on obesity-related inflammatory biomarker profiles. Medline, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for articles published until January 2016 and mean differences in biomarkers of inflammatory status were assessed for: C-reactive protein (CRP), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-ɑ), soluble intercellular adhesion molecule 1 (sICAM), leptin, adiponectin and resistin. Of initially identified 2,583 publications, 29 met the meta-analysis inclusion criteria [a total of 2,689 participants]. Consumption of plant-based diets was associated with a reduction in the mean concentrations of the following biomarkers: CRP [effect size, -0.55 mg/l, 95% confidence intervals (CI): -0.78; -0.32, I = 94.4%], IL-6 [effect size, -0.25 ng/l, 95% CI: -0.56; 0.06, I = 74%], and, to some degree, sICAM (-25.07 ng/ml [95% CI: -52.32; 2.17, I = 93.2%]). No substantial effects were revealed for TNF-ɑ, resistin, adiponectin and leptin. Plant-based diets are associated with an improvement in obesity-related inflammatory profiles and could provide means for therapy and prevention of chronic disease risk.

show abstract

“…Several studies indicate that FFA influence cytokines and redox balance, pointing to a reduced content of IL-10, IL-12(p70), IFN-γ, and MCP1, and elevated amount of IL-2 and IL-18 in whole blood human samples exposed to FFA [24] as well as higher levels of redox biomarkers (i.e., catalase, MDA) caused by a high-fat diet in rats [25]. We examined whether such a relationship was noticed due to a single training session in rodents.…”

Section: Correlationsmentioning

confidence: 99%

Blood Profile of Cytokines, Chemokines, Growth Factors, and Redox Biomarkers in Response to Different Protocols of Treadmill Running in Rats

Supruniuk

Maciejczyk

Górski

et al. 2020

IJMS

View full text Add to dashboard Cite

Both positive and negative aspects of sport performance are currently considered. The aim of our study was to determine time- and intensity-dependent effects of a single exercise bout on redox and inflammatory status. The experiment was performed on 40 male Wistar rats subjected to treadmill running for 30 min with the speed of 18 m/min (M30) or 28 m/min (F30), or for 2 h with the speed of 18 m/min (M120). Immunoenzymatic and spectrophotometric methods were applied to assess the levels of pro-inflammatory and anti-inflammatory cytokines, chemokines, growth factors, the antioxidant barrier, redox status, oxidative damage products, nitrosative stress, and their relationships with plasma non-esterified fatty acids. Treadmill running caused a reduction in the content of monocyte chemoattractant protein-1 (MCP1) and nitric oxide (M30, M120, F30 groups) as well as macrophage inflammatory protein-1α (MIP-1α) and regulated on activation, normal T-cell expressed and secreted (RANTES) (M30, F30 groups). We also demonstrated an increase in catalase activity as well as higher levels of reduced glutathione, advanced oxidation protein products, lipid hydroperoxides, malondialdehyde (M30, M120, F30 groups), and advanced glycation end products (F30 group). The presented findings showed the activation of antioxidative defense in response to increased reactive oxygen species’ production after a single bout of exercise, but it did not prevent oxidative damage of macromolecules.

show abstract

Oxidative stress and fatty acid profile in Wistar rats subjected to acute food restriction and refeeding with high-fat diets

Abstract: The consumption of high-fat diets after prolonged fasting favors oxidative imbalance in hepatic tissue.

Cited by 10 publications

References 20 publications

Comprehensive analysis of the translatome reveals the relationship between the translational and transcriptional control in high fat diet-induced liver steatosis

Comprehensive analysis of the translatome reveals the relationship between the translational and transcriptional control in high fat diet-induced liver steatosis

Effect of plant‐based diets on obesity‐related inflammatory profiles: a systematic review and meta‐analysis of intervention trials

Blood Profile of Cytokines, Chemokines, Growth Factors, and Redox Biomarkers in Response to Different Protocols of Treadmill Running in Rats

Contact Info

Product

Resources

About