Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats

Sousa, Dircilei Nascimento de; Santana, Washington Macedo de; Ferreira, Vânia Maria Moraes; Duarte, Wagner R.

doi:10.1590/s0102-86502014000300002

Cited by 2 publications

(3 citation statements)

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“…Simvastatin, one of the statins, has been locally applied in different concentrations with different carriers to induce bone formation in bone defects, but the ideal combination of drug concentration/type of carrier is still uncertain 17 . Nevertheless, lower concentrations of simvastatin (0.1mg) have been shown to be better when ceramic carries are utilized 18 .…”

Section: Introductionmentioning

confidence: 99%

Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects

et al. 2016

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PURPOSE:To investigate the effects of locally applied simvastatin plus biphasic calcium phosphate (BoneCeramic ® ) or collagen sponge on bone formation in critical-sized bone defects. METHODS:Thirty defects of 5mm in diameter were created bilaterally with a trephine bur in the calvariae of fifteen Wistar rats. The defects were divided into five groups: group 1 -control, no treatment; group 2 (BoneCeramic ® ); group 3 (BoneCeramic ® + 0.1mg simvastatin); group 4 (collagen sponge); and group 5 (collagen sponge + 0.1mg simvastatin). After eight weeks the animals were euthanized and their calvariae were histologically processed. Hematoxylin and eosin-stained sections were subjected to histological and histomorphometrical analyses. The area of newly formed bone was calculated and compared between groups. RESULTS:The greater amount of a bone-like tissue was formed around the carrier in group 3 (BoneCeramic ® + 0.1mg simvastatin)followed by group 2 (BoneCeramic ® ), and almost no bone was formed in the other groups. Group 3 was significantly different compared to group 2, and both groups were significantly different compared to the other groups. CONCLUSION:Simvastatin combined with BoneCeramic ® induced significantly greater amounts of newly formed bone and has great potential for the healing of bone defects.Key words: Simvastatin. Osteogenesis. Calcium Phosphates. Rats. Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects

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Section: Introductionmentioning

confidence: 99%

Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects

et al. 2016

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“…2,3,[9][10][11][12][13]16, Of these, 24.75% used calvarial and parietal models (skull surgery), 23.63% used maxillofacial surgery models (alveolar-, nasal-, and mandibular bone), 37.64% used orthopaedic models (a variety of tibial, femoral, radial and ulnar fractures, defects, and holes and also other modalities) and 13.98% used osteoporosis models. Rat was the most popular animal model possibly because of its low cost, thus the researchers can include a higher number of animals in their studies.…”

Section: General Information About the Included Studiesmentioning

confidence: 99%

“…1 Although Simvastatin is not a new generation of the statin family, it is the most investigated statin family member in the field of bone research, particularly in animal models. [5][6][7][8][9][10][11][12][13] However, the mechanisms, route of administration, dose and dosages, and effectiveness of Simvastatin have not been clearly defined in different in vivo studies on bone repair and osteoporosis. 1 In addition, some controversial results regarding the role of Simvastatin on bone metabolism are seen in the literature.…”

Section: Introductionmentioning

confidence: 99%

Role of Simvastatin on fracture healing and osteoporosis: a systematic review onin vivoinvestigations

Moshiri

Sharifi

Oryan

2016

Clin Exp Pharma Physio

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SUMMARYSimvastatin is a lipid lowering drug whose beneficial role on bone metabolism was discovered in 1999. Several in vivo studies evaluated its role on osteoporosis and fracture healing, however, controversial results are seen in the literature. For this reason, Simvastatin has not been the focus of any clinical trials as yet. This systematic review clears the mechanisms of action of Simvastatin on bone metabolism and focuses on in vivo investigations that have evaluated its role on osteoporosis and fracture repair to find out (i) whether Simvastatin is effective on treatment of osteoporosis and fracture repair, and (ii) which of the many available protocols may have the ability to be translated in the clinical setting. Simvastatin induces osteoinduction by increasing osteoblast activity and differentiation and inhibiting their apoptosis. It also reduces osteoclastogenesis by decreasing both the number and activity of osteoclasts and their differentiation. Controversial results between the in vivo studies are mostly due to the differences in the route of administration, dose, dosage and carrier type. Local delivery of Simvastatin through controlled drug delivery systems with much lower doses and dosages than the systemic route seems to be the most valuable option in fracture healing. However, systemic delivery of Simvastatin with much higher doses and dosages than the clinical ones seems to be effective in managing osteoporosis. Simvastatin, in a particular range of doses and dosages, may be beneficial in managing osteoporosis and fracture injuries. This review showed that Simvastatin is effective in the treatment of osteoporosis and fracture healing.

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Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats

Cited by 2 publications

References 15 publications

Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects

Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects

Role of Simvastatin on fracture healing and osteoporosis: a systematic review onin vivoinvestigations

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