2014
DOI: 10.1590/s0102-86502014000200009
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Abstract: PURPOSE:To analyze the effects of application of 1% and 3% insulin-like growth factor I (IGF-1) cream on the process of wound healing in induced skin lesions in diabetic and non-diabetic rats and evaluate its effect on expression of myofibroblasts. METHODS:Ninety-six Wistar adult male rats were divided into six groups, with 16 rats in each group, as follows: group 1: nondiabetic, untreated; group 2: non-diabetic, treated with 1% IGF-1 cream; group 3: non-diabetic, treated with 3% IGF-1 cream; group 4: diabetic… Show more

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Cited by 49 publications
(35 citation statements)
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“…This supported the possibility of a promising and cost-effective method for treating this serious complication of diabetes [8]. In a similar study, Achar, et al [38] showed that topical use of a cream containing insulin-like growth factor (IGF-1) improves wound healing in both diabetic and non diabetic animals with increased expression of my ibroblasts.…”
Section: Pharmaceutical Applications Of Insulin In Wound Healingmentioning
confidence: 87%
“…This supported the possibility of a promising and cost-effective method for treating this serious complication of diabetes [8]. In a similar study, Achar, et al [38] showed that topical use of a cream containing insulin-like growth factor (IGF-1) improves wound healing in both diabetic and non diabetic animals with increased expression of my ibroblasts.…”
Section: Pharmaceutical Applications Of Insulin In Wound Healingmentioning
confidence: 87%
“…This supported the possibility of a promising and cost-effective method for treating this serious complication of diabetes [8]. In a similar study, Achar, et al [38] showed that topical use of a cream containing insulin-like growth factor (IGF-1) improves wound healing in both diabetic and non-diabetic animals, with increased expression of my fibroblasts.…”
Section: Pharmaceutical Applications Of Insulin In Wound Healingmentioning
confidence: 88%
“…Its topical application on nonhealing diabetic skin has been correlated with a faster reepithelization and enhanced scarring in rat model. 57 These observations suggest that the delivery of HB-IGF-1 variant in chronic wounds may have an improved interaction with GAGs and a prolonged effect in comparison to the wild-type IGF-1.…”
Section: Figure 3 Ecm-inspired Growth Factor Delivery Systems (A)mentioning
confidence: 92%