Modulatory activity of brazilian red propolis on chemically induced dermal carcinogenesis

Pinheiro, Kariny Souza; Ribeiro, Danielle Rodrigues; Alves, Ângela Valéria Farias; Pereira-Filho, Rose Nely; Oliveira, Clauberto Rodrigues de; Lima, Sônia Oliveira; Reis, Francisco Prado; Cardoso, Juliana Cordeiro; Albuquerque‐Júnior, Ricardo Luiz Cavalcanti de

doi:10.1590/s0102-86502014000200007

Cited by 12 publications

(7 citation statements)

References 18 publications

(8 reference statements)

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“…The material was labeled, and stored in sterile and refrigerated containers. For the extraction, a volume of 12.5 mL of ethanol (70%) was used to extract 1 g of propolis samples using an ultrasound bath for 1 h, at room temperature as described by Pinheiro et al [ 22 ]. After extraction, the obtained mixture was centrifuged, and the obtained supernatant evaporated under low pressure resulting in HERP, which was stored at refrigerated temperature until further use.…”

Section: Methodsmentioning

confidence: 99%

“…(Fabaceae, [ 10 ]) shows various pharmacological properties of clinical interest, also being considered a functional food [ 11 , 12 , 13 ]. In particular, and due to its significant antioxidant activity [ 14 , 15 , 16 ], Brazilian red propolis has been proposed for dermal healing [ 17 , 18 ], and for the treatment of cancer cells [ 14 , 15 , 19 , 20 ], as an antimicrobial [ 16 ], antiproliferative [ 21 , 22 ], antihypertensive [ 23 ], and as a neuroprotective [ 11 ]. Several compounds have been identified in this resin, including the isoflavonoids formononetin, biochanin A, medicarpin, and pinocembrin [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Red Propolis and Its Dyslipidemic Regulator Formononetin: Evaluation of Antioxidant Activity and Gastroprotective Effects in Rat Model of Gastric Ulcer

et al. 2020

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Propolis has various pharmacological properties of clinical interest, and is also considered a functional food. In particular, hydroalcoholic extracts of red propolis (HERP), together with its isoflavonoid formononetin, have recognized antioxidant and anti-inflammatory properties, with known added value against dyslipidemia. In this study, we report the gastroprotective effects of HERP (50–500 mg/kg, p.o.) and formononetin (10 mg/kg, p.o.) in ethanol and non-steroidal anti-inflammatory drug-induced models of rat ulcer. The volume, pH, and total acidity were the evaluated gastric secretion parameters using the pylorus ligature model, together with the assessment of gastric mucus contents. The anti-Helicobacter pylori activities of HERP were evaluated using the agar-well diffusion method. In our experiments, HERP (250 and 500 mg/kg) and formononetin (10 mg/kg) reduced (p < 0.001) total lesion areas in the ethanol-induced rat ulcer model, and reduced (p < 0.05) ulcer indices in the indomethacin-induced rat ulcer model. Administration of HERP and formononetin to pylorus ligature models significantly decreased (p < 0.01) gastric secretion volumes and increased (p < 0.05) mucus production. We have also shown the antioxidant and anti-Helicobacter pylori activities of HERP. The obtained results indicate that HERP and formononetin are gastroprotective in acute ulcer models, suggesting a prominent role of formononetin in the effects of HERP.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Red Propolis and Its Dyslipidemic Regulator Formononetin: Evaluation of Antioxidant Activity and Gastroprotective Effects in Rat Model of Gastric Ulcer

et al. 2020

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“…A single DMBA agent was used and animals treated with HERP exhibited significantly decreased tumor multiplicity throughout the 5 weeks of tumor promotion. Administered orally in a murine model of chemically induced SCC, this natural product exerted a significant modulatory effect on the formation, differentiation and progression of tumors ( 113 ).…”

Section: Testing Avenues Using Animal Models Of Skin Carcinogenesimentioning

confidence: 99%

Chemically induced skin carcinogenesis: Updates in experimental models (Review)

et al. 2016

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Skin cancer is one of the most common malignancies affecting humans worldwide, and its incidence is rapidly increasing. The study of skin carcinogenesis is of major interest for both scientific research and clinical practice and the use of in vivo systems may facilitate the investigation of early alterations in the skin and of the mechanisms involved, and may also lead to the development of novel therapeutic strategies for skin cancer. This review outlines several aspects regarding the skin toxicity testing domain in mouse models of chemically induced skin carcinogenesis. There are important strain differences in view of the histological type, development and clinical evolution of the skin tumor, differences reported decades ago and confirmed by our hands-on experience. Using mouse models in preclinical testing is important due to the fact that, at the molecular level, common mechanisms with human cutaneous tumorigenesis are depicted. These animal models resemble human skin cancer development, in that genetic changes caused by carcinogens and pro-inflammatory cytokines, and simultaneous inflammation sustained by pro-inflammatory cytokines and chemokines favor tumor progression. Drugs and environmental conditions can be tested using these animal models. keeping in mind the differences between human and rodent skin physiology.

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“…Propolis is a resinous substance produced by honeybees by mixing their salivated secretions with resins collected from the cracks of the tree bark . The red propolis variety is obtained exclusively in the northeast of Brazil.…”

Section: Introductionmentioning

confidence: 99%

“…For the last decade, red propolis has been attributed as a source of potential anticancer activity product . This is characterized by a complex mixture of molecules including flavonoids, chalcones and isoflavonoids .…”

Section: Introductionmentioning

confidence: 99%

LC-MS analysis of Hep-2 and Hek-293 cell lines treated with Brazilian red propolis reveals differences in protein expression

Frozza

Brum

Alving

et al. 2016

Journal of Pharmacy and Pharmacology

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Modulatory activity of brazilian red propolis on chemically induced dermal carcinogenesis

Cited by 12 publications

References 18 publications

Red Propolis and Its Dyslipidemic Regulator Formononetin: Evaluation of Antioxidant Activity and Gastroprotective Effects in Rat Model of Gastric Ulcer

Red Propolis and Its Dyslipidemic Regulator Formononetin: Evaluation of Antioxidant Activity and Gastroprotective Effects in Rat Model of Gastric Ulcer

Chemically induced skin carcinogenesis: Updates in experimental models (Review)

LC-MS analysis of Hep-2 and Hek-293 cell lines treated with Brazilian red propolis reveals differences in protein expression

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