Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs

Abstract

PURPOSE:To investigate the effect of platelet rich fibrin (PRF) and beta tricalcium phosphate (β-TCP), alone or in combination, on bone regeneration in pig tibial defects. METHODS:Four standardized defects were prepared in both tibias of three adult male pigs. The first defect was left unfilled as a control; the others were grafted with either PRF, β-TCP or PRF mixed with β-TCP. All animals were sacrificed on the 12 th postoperative week and the tibial bones were removed, histologic sections were prepared and the experimental sites were examined microscopically and stereologically. RESULTS:Histologic and stereologic examination revealed more new bone formation in the defects filled with PRF mixed β-TCP than in the defects grafted with either β-TCP or PRF alone. CONCLUSION:The platelet rich fibrin and beta tricalcium phosphate combination effectively induces new bone formation.

Bone neoformation in defects treated with fibrin platelet rich membrane versus collagen membrane: a histomorphometric study in rabbit’s femurs.

“…In this case, neoformation for the PRF group was 19.81% and 6.24% for the control. This is similar to the result obtained by Yilmaz et al 18 in bone regeneration in tibial defects of pigs at 12 weeks. They found neoformation for the PRF group was 28% and 18.7% for the control.…”

The effect of L-PRF membranes on bone healing in rabbit tibiae bone defects: micro-CT and biomarker results

“…a cortical bone shell, or in tibia defects in combination with other materials224303132. Time points for monitoring the healing process in the presence of L-PRF included periods longer than 4 weeks 1233.…”

Application of Platelet-Rich Fibrin and Injectable Platelet-Rich Fibrin in Combination of Bone Substitute Material for Alveolar Ridge Augmentation - a Case Report

“…Other authors concluded that the use of PRF reduces postoperative pain, swelling and minimizes the infection phenomenon. 13 Yilmaz D et al 14 suggest that the use of PRF in combination with β-TCP could accelerate new bone formation and this combination is a very good alternative to the independent use of β-TCP. Ozdemir H et al 15 use PRF as a bone graft material in combination with rigid titanium membranes for regeneration of bone defects in the calvaria of rabbits.…”