Does rosmarinic acid underestimate as an experimental cardiovascular drug?

Ferreira, Luciana Garros; Celotto, Andréa Carla; Capellini, Verena Kise; Albuquerque, Agnes Afrodite Sumarelli; Nadai, Tales Rubens de; Carvalho, Marco Túlio Menezes; Évora, Paulo Roberto Barbosa

doi:10.1590/s0102-86502013001300016

Cited by 25 publications

(9 citation statements)

References 21 publications

(16 reference statements)

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“…Furthermore, RA reduced extracellular regulated kinases (ERK) 1/2, PMA-stimulated p38, and c-Jun N-terminal kinase (JNK) phosphorylation. These results support the upcoming use of RA as an anti-sEPCR shedding reagent against IL-1β, TNF-α, PMA, and CLP-mediated EPCR shedding [55,56].…”

Section: Cardioprotective Activitysupporting

confidence: 76%

Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review

et al. 2019

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Naturally occurring food-derived active ingredients have received huge attention for their chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) is a caffeic acid ester and a naturally-occurring phenolic compound in a number of plants belonging to the Lamiaceae family, such as Rosmarinus officinalis (rosemary) from which it was formerly isolated. RA intervenes in carcinogenesis through different ways, including in tumor cell proliferation, apoptosis, metastasis, and inflammation. On the other hand, it also exerts powerful antimicrobial, anti-inflammatory, antioxidant and even antidepressant, anti-aging effects. The present review aims to provide an overview on anticancer activities of RA and to deliberate its therapeutic potential against a wide variety of diseases. Given the current evidence, RA may be considered as part of the daily diet in the treatment of several diseases, with pre-determined doses avoiding cytotoxicity.

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Section: Cardioprotective Activitysupporting

confidence: 76%

Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review

et al. 2019

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“…Many trials were carried out to determine the dependency and functionality of RA and its supplementation in animal and poultry diets. There are many studies on the anti-oxidant and anti-cancer effects of RA; however, reports on its activities as an anti-inflammatory, anti-Alzheimer, anti-allergy or anti-diabetic agent are few (Ferreira et al , 2013). Ozturk et al (2014) reported a reduction in circulatory levels of creatinine, blood urea nitrogen, focal glomerular necrosis, dilatation of Bowman's capsule, degeneration of tubular epithelium and tubular dilatation in unilaterally nephrectomized rats treated with RA.…”

Section: Modes Of Action Biological Activities and Beneficial Aspectsmentioning

confidence: 99%

Rosmarinic acid: modes of action, medicinal values and health benefits

Alagawany

El‐Hack

Farag

et al. 2017

Anim. Health. Res. Rev.

141

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The supplementation of livestock rations with herbs containing bioactive components, such as rosmarinic acid (RA), have shown promising results as a natural feed additive in promoting growth, productive and reproductive performance, feed utilization, fertility, anti-oxidant status and immunologic indices. Furthermore, RA reportedly reduces the risks of various animal diseases and mitigates side effects of chemical and synthetic drugs. RA is a natural polyphenol present in several Lamiaceae herbs like Perilla frutescens, and RA is becoming an integral component of animal nutrition as it counters the effect of reactive oxygen species induced in the body as a consequence of different kinds of stressors. Studies have further ascertained the capability of RA to work as an anti-microbial, immunomodulatory, anti-diabetic, anti-allergic, anti-inflammatory, hepato- and renal-protectant agent, as well as to have beneficial effects during skin afflictions. Additionally, RA is favored in meat industries due to enhancing the quality of meat products by reportedly improving shelf-life and imparting desirable flavor. This review describes the beneficial applications and recent findings with RA, including its natural sources, modes of action and various useful applications in safeguarding livestock health as well as important aspects of human health.

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“…It is usually discovered in species of the Boraginaceae family and the subfamily Nepetoideae of the Lamiaceae family (Petersen and Simmonds, 2003). RosA's presence in medicinal plants, herbs, and spices is linked to beneficial and health-promoting effects (Ferreira et al, 2013). In plants, RosA is considered to be a cumulative defense compound, while in human, RosA has many biological activities, including antiviral, antibacterial, antioxidant, antimutagenic, and anti-inflammatory activities (Elufioye and Habtemariam, 2019).…”

Section: Introductionmentioning

confidence: 99%

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

et al. 2020

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Inflammatory diseases are caused by abnormal immune responses and are characterized by an imbalance of inflammatory mediators and cells. In recent years, the antiinflammatory activity of natural products has attracted wide attention. Rosmarinic acid (RosA) is a water-soluble phenolic compound that is an ester of caffeic acid and 3, 4dihydroxyphenyl lactic acid. It is discovered in many plants, like those of the Boraginaceae and Lamiaceae families. RosA has a wide range of pharmacological effects, including antioxidative, anti-apoptotic, anti-tumorigenic, and anti-inflammatory effects. The antiinflammatory effects of RosA have been revealed through in vitro and in vivo studies of various inflammatory diseases like arthritis, colitis, and atopic dermatitis. This article mainly describes the preclinical research of RosA on inflammatory diseases and depicts a small amount of clinical research data. The purpose of this review is to discuss the antiinflammatory effects of RosA in inflammatory diseases and its underlying mechanism.

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Does rosmarinic acid underestimate as an experimental cardiovascular drug?

Cited by 25 publications

References 21 publications

Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review

Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review

Rosmarinic acid: modes of action, medicinal values and health benefits

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

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