2013
DOI: 10.1590/s0102-86502013000300005
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Abstract: PURPOSE:To investigate the immunohistochemistry of the uterine cervix of 20 Wistar rats (Rattus norvegicus) bearing the Walker 256 tumor, treated with copaiba oil (Copaifera officinalis). METHODS:The animals were grouped into four subgroups, with five rats each: the GCT and GCopT received distilled water and topically copaiba, respectively, while the GCG and GCopG received distilled water and copaiba by gavage, respectively. The substances were administered for nine days. On the 12 th day, after euthanasia, th… Show more

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Cited by 4 publications
(5 citation statements)
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“…Brito et al [8] suggests that the plant oil-resin may operate with an immune response modulator by stimulating or inhibiting their functions according to its compounds concentration. In fact, the authors demonstrated that in vaginal Walker tumor model and the uterine cervix, the oil-resin treatment did not reduced the tumor growth and had non-effect on infiltrating immune cells (T lymphocytes and NK cells) [8,9]. In the present study, we evaluated the antitumor and immunomodulatory effect of ethanolic extracts obtained from copaiba bark using the model of subcutaneous growth of Ehrlich carcinoma.…”
Section: Introdutionmentioning
confidence: 83%
“…Brito et al [8] suggests that the plant oil-resin may operate with an immune response modulator by stimulating or inhibiting their functions according to its compounds concentration. In fact, the authors demonstrated that in vaginal Walker tumor model and the uterine cervix, the oil-resin treatment did not reduced the tumor growth and had non-effect on infiltrating immune cells (T lymphocytes and NK cells) [8,9]. In the present study, we evaluated the antitumor and immunomodulatory effect of ethanolic extracts obtained from copaiba bark using the model of subcutaneous growth of Ehrlich carcinoma.…”
Section: Introdutionmentioning
confidence: 83%
“…The pharmacokinetic and biodistribution studies were performed on Wistar rats bearing Walker-256 transplanted liver cancer [ 31 ]. Walker-256, a rat hepatoma cell line (inoculated with breast cancer cells to the liver tumor), is similar to human liver cancer in blood supply and growth behavior after liver transplantation, and has been widely applied in experimental treatment, metastasis and pharmacokinetic of HCC [ 32 ].…”
Section: Methodsmentioning
confidence: 99%
“…The use of medicinal plants for therapeutic purposes is now spread worldwide [20]. Several herbal preparations used in the indigenous system of medicine are known to boost the immune system [14].…”
Section: /8mentioning
confidence: 99%
“…Within this context, C. multijuga is an interesting option because of its documented medicinal effects such antimicrobial, antinociceptive, anti-inflammatory, wound-healing, antifungal, antiparasitic, and antitumor properties [1, 5, 7-9, 20]. These activities are attributed to the presence of sesquiterpene and diterpene metabolites [20,21].…”
Section: /8mentioning
confidence: 99%