A comparative study of pentoxifylline effects in adult and aged rats submitted to lung dysfunction by thermal injury

Ramallo, Bianca Trovello; Lourenço, Elizete Maria; Cruz, Renata Harumi; Almeida, Jacqueline Camargo; Taha, Murched Omar; Silva, Priscilla Yuri Okochi Alves da; Oliveira-Júnior, Itamar Souza

doi:10.1590/s0102-86502013000200012

Cited by 6 publications

(3 citation statements)

References 23 publications

(17 reference statements)

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“…Administration of pentoxifylline to rats reduced NM-induced HO-1 expression by alveolar macrophages, as well as BAL Lcn2 levels, demonstrating that pentoxifylline is effective in reducing NM-induced oxidative stress. These findings are in accord with earlier studies showing that pentoxifylline reduces oxidative stress induced by thermal injury, airway obstruction, steatohepatitis, acute pancreatitis, and kidney injury (Barkhordari et al, 2011; Chae et al, 2012; Escobar et al, 2012; Ramallo et al, 2013; Venugopal et al, 2013; Zein et al, 2012). The mechanism underlying the antioxidant actions of pentoxifylline in NM-induced lung toxicity are unknown.…”

Section: Discussionsupporting

confidence: 92%

“…Pentoxifylline post-treatment significantly attenuated histologic evidence of pulmonary inflammation and injury, as well as increases in BAL protein and cell content. Similar suppression of inflammation and tissue damage have been described following pentoxifylline administration in models of lung injury induced by mechanical ventilation, sepsis, hyperoxia, meconium aspiration, thermal injury, and acute pancreatitis (Almario et al, 2012; de Campos et al, 2008; Oliveira-Junior et al, 2010; Oliveira-Junior et al, 2003; Ramallo et al, 2013; Turhan et al, 2012). Based on these observations, we suggest that pentoxifylline is efficacious in a broad spectrum of lung pathologies with diverse etiologies.…”

Section: Discussionsupporting

confidence: 61%

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Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation

Sunil

Vayas

Cervelli

et al. 2014

Experimental and Molecular Pathology

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Nitrogen mustard (NM) is a toxic alkylating agent that causes damage to the respiratory tract. Evidence suggests that macrophages and inflammatory mediators including tumor necrosis factor (TNF)α contribute to pulmonary injury. Pentoxifylline is a TNFα inhibitor known to suppress inflammation. In these studies, we analyzed the ability of pentoxifylline to mitigate NM-induced lung injury and inflammation. Exposure of male Wistar rats (250 g; 8–10 weeks) to NM (0.125 mg/kg, i.t.) resulted in severe histolopathological changes in the lung within 3 d of exposure, along with increases in bronchoalveolar lavage (BAL) cell number and protein, indicating inflammation and alveolar-epithelial barrier dysfunction. This was associated with increases in oxidative stress proteins including lipocalin (Lcn)2 and heme oxygenase (HO)-1 in the lung, along with pro-inflammatory/cytotoxic (COX-2+ and MMP-9+), and anti-inflammatory/wound repair (CD163+ and Gal-3+) macrophages. Treatment of rats with pentoxifylline (46.7 mg/kg, i.p.) daily for 3 d beginning 15 min after NM significantly reduced NM-induced lung injury, inflammation, and oxidative stress, as measured histologically and by decreases in BAL cell and protein content, and levels of HO-1 and Lcn2. Macrophages expressing COX-2 and MMP-9 also decreased after pentoxifylline, while CD163+ and Gal-3+ macrophages increased. This was correlated with persistent upregulation of markers of wound repair including pro-surfactant protein-C and proliferating nuclear cell antigen by Type II cells. NM-induced lung injury and inflammation were associated with alterations in the elastic properties of the lung, however these were largely unaltered by pentoxifylline. These data suggest that pentoxifylline may be useful in treating acute lung injury, inflammation and oxidative stress induced by vesicants.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 61%

Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation

Sunil

Vayas

Cervelli

et al. 2014

Experimental and Molecular Pathology

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“…It may cause multiple organ injury distant from the burned area; therefore, morbidity and mortality is increased in thermal trauma patients. [1] In addition to direct tissue damage, inflammatory reactions and infection as major complications. [2] stabilization in tissue by restoring both non-enzymatic and enzymatic antioxidants, and that it had a protective effect on mitochondrial function, lipid metabolism, and antioxidant defense system in experimentally induced myocardial infarction in Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

Protectıve effect of betaıne agaınst burn ınduced pulmonary ınjury ın rats

Şehirli

Satılmış

Tetitk

et al. 2015

Ulus Travma Acil Cerrahi Derg

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Burn-Induced Multiple Organ Injury and Protective Effect of Lutein in Rats

et al. 2018

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Thermal injury may lead to multiple organ dysfunction through release of proinflammatory mediators and reactive oxygen radicals. This study investigated the effects of thermal injury on remote organs of rats and the possible protective effect of lutein. Thermal trauma was induced in the back of rats by exposing them to 90 °C bath for 10 s. Rats were sacrificed 48 h after burn, and blood samples were collected to monitor liver and kidney functions. Tissue samples from liver, kidneys, and lungs were taken for studying oxidative stress parameters, gene expressions of TNF-α and Casp-3, besides histopathological examination. Skin scald injury caused significant elevations of liver and kidney function biomarkers in the serum. In tissue samples, increments of MDA, GPx, and 8-OHdG were recorded while GSH level and the activities of CAT and SOD were suppressed. The expressions of TNF-α and caspase-3 mRNA were increased, and histopathological results revealed remote organ injury. Oral administration of lutein (250 mg/kg) resulted in amelioration of the biochemical and molecular changes induced by burn as well as the histopathological alterations. According to the findings of the present study, lutein possesses anti-oxidant, anti-inflammatory, and anti-apoptotic effects that protect against burn-induced damage in remote organs.

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A comparative study of pentoxifylline effects in adult and aged rats submitted to lung dysfunction by thermal injury

Abstract: The injury was augmented in elderly rats when compared to adult rats. Damage was reduced with the use of pentoxifylline, however further studies are needed to evaluate the dose-response of the drug.

Cited by 6 publications

References 23 publications

Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation

Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation

Protectıve effect of betaıne agaınst burn ınduced pulmonary ınjury ın rats

Burn-Induced Multiple Organ Injury and Protective Effect of Lutein in Rats

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