2013
DOI: 10.1590/s0102-86502013000100013
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Abstract: PURPOSE:To conduct a systematized review of the literature about the main local hemostatic measures to control postoperative bleeding in anticoagulated patients. METHODS:A systematized review of literature was performed in the electronic database Medline (PubMed) without restriction of the publication date. The eligibility criteria were studies involving maintenance of the anticoagulant therapy, prospective studies, retrospective studies, randomized clinical trials, controlled clinical studies, comparative stu… Show more

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Cited by 15 publications
(7 citation statements)
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“…The topical aminocaproic acid can be useful in patients with friable clots and intravenous administration may be considered, in some cases, to improve coagulation and the formation of stable clots [ 2 ]. Topical use of tranexamic acid is also cited as an effective hemostatic in reducing the incidence of postoperative bleeding in patients taking continuous use of oral anticoagulants [ 38 , 39 ]. Coetzee [ 40 ] reports the empirical use of 500 mg crushed tablets ground in moist cotton at the site of the surgical wound after tooth extraction, or diluted in water for mouthwash, suggesting it as an option.…”
Section: Dental Procedures In Different Stages Of the Disease And mentioning
confidence: 99%
“…The topical aminocaproic acid can be useful in patients with friable clots and intravenous administration may be considered, in some cases, to improve coagulation and the formation of stable clots [ 2 ]. Topical use of tranexamic acid is also cited as an effective hemostatic in reducing the incidence of postoperative bleeding in patients taking continuous use of oral anticoagulants [ 38 , 39 ]. Coetzee [ 40 ] reports the empirical use of 500 mg crushed tablets ground in moist cotton at the site of the surgical wound after tooth extraction, or diluted in water for mouthwash, suggesting it as an option.…”
Section: Dental Procedures In Different Stages Of the Disease And mentioning
confidence: 99%
“…It prevents binding to the lysine residues on fibrin by plasminogen, thereby preventing the subsequent cleavage of plasmin and its degradation of fibrin. TxA has been used extensively in cardiac surgery, orthopaedic surgery, and in its oral form for the management of menstrual bleeding and in oral surgery . More recently, TxA was shown to significantly improve mortality when given to potentially bleeding trauma patients (the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage [CRASH‐2] study) .…”
Section: Competing Interestsmentioning
confidence: 99%
“…TxA has been used extensively in cardiac surgery, 1 orthopaedic surgery, 2 and in its oral form for the management of menstrual bleeding 3 and in oral surgery. 4 More recently, TxA was shown to significantly improve mortality when given to potentially bleeding trauma patients (the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage [CRASH-2] study). 5 The present study has provoked international debate, about its generalisability, applicability and predictability beyond the context of the study sites.…”
Section: Abstract: Evidence-based Practice Haemorrhage Resuscitatimentioning
confidence: 99%
“…Similar to other invasive procedures, the use of OAC in patients undergoing dental procedures presents a special challenge to dentists. Tranexamic acid (TA), an antiplasmin agent that helps promoting hemostasis by preventing the proteolytic degradation of fibrin, is one of most commonly used local hemostatic agents for dental procedures 5 . The efficacy of local TA treatment is well-established as a study has demonstrated that the incidence of post-procedural bleeding (PPB) was significantly lower among patients who took warfarin and received 4.8% TA mouthwash after dental procedures versus those who took warfarin and did not receive TA mouthwash after dental procedures 6 .…”
Section: Introductionmentioning
confidence: 99%