2012
DOI: 10.1590/s0102-86502012001100004
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Abstract: PURPOSE: To investigate the results of the healing process on surgical wounds in the back of Wistar rats using nanocristaline and ionic silver dressing. METHODS: Sixty rats Wistar were submitted to surgical wounds with punch of 8mm in diameter. In 30 animals (groups PN - nanocristaline and AD - control) two surgical wounds were done diametrically opposite on the upper back side. On the right side was used nanocristaline (PN) silver dressing and on the left side, distilled water dressing (AD). On the other grou… Show more

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Cited by 12 publications
(13 citation statements)
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“…Macrophages are important in the healing process because they secrete proteases, release vasoactive substances, and growth factors that control cell proliferation. The efficacy of silver dressings on uninfected wounds was also demonstrated, showing that there was an improvement in healing in PI and PN groups, compared to the control group (AD), contrary to the results of another author cited in their studies (20) . In the A6 study, the use of silver nanoparticle-containing silicate platelets (AgNP/NSP) supported the presented evidence and indicated favorable results, such as reduction of wound area, lower cytotoxicity, low genotoxicity and better therapeutic effect in infection control, showing great wound healing abilities (21) .…”
Section: Discussioncontrasting
confidence: 57%
See 1 more Smart Citation
“…Macrophages are important in the healing process because they secrete proteases, release vasoactive substances, and growth factors that control cell proliferation. The efficacy of silver dressings on uninfected wounds was also demonstrated, showing that there was an improvement in healing in PI and PN groups, compared to the control group (AD), contrary to the results of another author cited in their studies (20) . In the A6 study, the use of silver nanoparticle-containing silicate platelets (AgNP/NSP) supported the presented evidence and indicated favorable results, such as reduction of wound area, lower cytotoxicity, low genotoxicity and better therapeutic effect in infection control, showing great wound healing abilities (21) .…”
Section: Discussioncontrasting
confidence: 57%
“…et al 2012 (20) Wound healing using ionic silver dressing and nanocrystalline silver dressing in rats…”
Section: A5 Prestesmentioning
confidence: 99%
“…In contrast to the studies that report the anti‐inflammatory effects of silver in which the dressing changes occurred daily , the dressing regimen in the current study, where dressings were changed every 3 days, may have resulted in the wound bed being exposed to silver for a greater period of time, inducing the inflammatory response. Similar to the current study, acute wounds treated with Acticoat™ for 21 days , in which dressings were changed every 7 days, developed a chronic inflammatory response signified by the presence of giant cells associated with silver deposits. Thus, the results of this study as well as those reported by Arican et al and Prestes et al suggest that the length of exposure to NCS may influence the immune response and result in chronic inflammation.…”
Section: Discussionsupporting
confidence: 79%
“…The results of woundhealing activity of the AgNP 0.125% (w/w) ointments revealed significant wound-healing properties compared to standard silver sulfadiazine ointment currently available in the market. Similarly, Prestes et al 45 found that nanocrystalline silver dressing exhibited good wound-healing potential in relation to wound contraction compared to the control group. According to …”
Section: Study Of Bacteria-killing Kineticsmentioning
confidence: 88%
“…43 The results of the current study seemed to be consistent with those published previously. 44,45 For instance, Thirumurugan et al 44 synthesized AgNPs from potato plant pathogenic fungus. The results of woundhealing activity of the AgNP 0.125% (w/w) ointments revealed significant wound-healing properties compared to standard silver sulfadiazine ointment currently available in the market.…”
Section: Study Of Bacteria-killing Kineticsmentioning
confidence: 99%