2012
DOI: 10.1590/s0102-86502012001100002
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Abstract: Intellectual and scientific content of the study, designed the protocol, provided guidelines for the surgical interventions, supervised all phases of the study. ABSTRACT PURPOSE:To assess the influence of spleen surgeries (splenectomy, presence of spleen and after conservative surgeries) on lipids metabolism. METHODS:Fifty female Wistar rats of similar weight and age were divided into five groups submitted to the following procedures:Group 1 -control, with an intact spleen; Group 2 -sham operation, Group 3 -to… Show more

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Cited by 11 publications
(5 citation statements)
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“…Interestingly, spleen-derived IL-10 can reduce the inflammation and oxidative stress of multiple organs in the obese state [8,9]. In addition, previous studies on animals and clinical experiences in man have demonstrated that total splenectomy leads to significantly increased plasma total triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels, significantly decreased plasma high-density lipoprotein cholesterol (HDL-C) levels, and a high rate of atherosclerosis [10][11][12]. Therefore, the findings above imply that alleviation of splenic metabolic dysfunction and function damage may also be a meaningful strategy for preventing obesity and its associated diseases.…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, spleen-derived IL-10 can reduce the inflammation and oxidative stress of multiple organs in the obese state [8,9]. In addition, previous studies on animals and clinical experiences in man have demonstrated that total splenectomy leads to significantly increased plasma total triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels, significantly decreased plasma high-density lipoprotein cholesterol (HDL-C) levels, and a high rate of atherosclerosis [10][11][12]. Therefore, the findings above imply that alleviation of splenic metabolic dysfunction and function damage may also be a meaningful strategy for preventing obesity and its associated diseases.…”
Section: Introductionmentioning
confidence: 99%
“…However, the accurate mechanisms behind this mysterious phenomenon remain unclear so far 38 . In a recent research work on rats, the authors reported increased cholesterol, LDL and TG, and decreased HDL concentrations after complete splenectomy, then these values reverted by autogenous spleen tissue implants 4 . In the present study, increased lipid parameters may have a potentiality for development of atherosclerosis and consequently vascular complications.…”
Section: Discussionmentioning
confidence: 95%
“…The Absence of this extremely sensitive filter may permit particulate matter and damaged cells to persist in the bloodstream, therefore enhancing and activating the vascular endothelium resulting in a shift in vascular homeostasis toward increased coagulation 3 . In addition, spleen is necessary for lipid metabolism 4 .…”
Section: Introductionmentioning
confidence: 99%
“…The commitment of liver function leads to failure in physiological processes during homeostasis regulation, such as synthesis of plasma proteins, metabolism of lipids, carbohydrates and proteins, as well as performing inactivation of medications and toxic drugs 2,3 .…”
Section: Introductionmentioning
confidence: 99%