2012
DOI: 10.1590/s0102-86502012000800008
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Abstract: PURPOSE:To evaluate the effect of N-acetylcysteine (NAC) combined with fluid resuscitation on pulmonary cell death in rats induced with controlled hemorrhagic shock (HS). METHODS: Two arteries (MAP calculation and exsanguination) and one vein (treatments) were catheterized in 22 anesthetized rats. Two groups of male albino rats were induced with controlled HS at 35mmHg MAP for 60 min. After this period, the RL group was resuscitated with Ringer's lactate and the RL+NAC group was resuscitated with Ringer's lact… Show more

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Cited by 4 publications
(5 citation statements)
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“…N-acetyl-L-Cysteine (NAC) is a thiol-containing compound with antioxidant and anti-inflammatory properties, exhibiting effects on microcirculation ( Saad et al, 2012 ). NAC acts directly as an antioxidant, by deactivating reactive oxygen species, or indirectly, by replacing intracellular glutathione stores.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…N-acetyl-L-Cysteine (NAC) is a thiol-containing compound with antioxidant and anti-inflammatory properties, exhibiting effects on microcirculation ( Saad et al, 2012 ). NAC acts directly as an antioxidant, by deactivating reactive oxygen species, or indirectly, by replacing intracellular glutathione stores.…”
Section: Discussionmentioning
confidence: 99%
“…NAC has also been studied to treat COVID-19 recently ( Ibrahim et al, 2020 ). Some studies reported that NAC could attenuate lung injury via decreasing cell death ( Saad et al, 2012 ) and attenuate inflammatory response and acute lung injury ( Lee et al, 2013 ). Moreira et al (2016) reported that NAC is a promising drug for combining with fluid resuscitation to attenuate the kidney injury associated with hemorrhagic shock via reducing oxidative stress and apoptosis.…”
Section: Discussionmentioning
confidence: 99%
“…Among these antioxidants, N-acetylcysteine has great potential for reducing the deleterious effects of oxidative stress and inflammatory response in different types of diseases by acting on detoxification of ROS, inhibition the synthesis of NO, upregulation of antioxidant enzymes, immunomodulatory activity, and regulation of apoptosis [22]. In our laboratory, the effects of N-acetylcysteine (NAC) have been studied in various experimental models of I/R [23][24][25][26][27][28]. In a hemorrhagic shock model, NAC protected pulmonary tissue [23,24].…”
Section: Introductionmentioning
confidence: 99%
“…In our laboratory, the effects of N-acetylcysteine (NAC) have been studied in various experimental models of I/R [23][24][25][26][27][28]. In a hemorrhagic shock model, NAC protected pulmonary tissue [23,24]. In a model of I/R after hemorrhagic shock [25], NAC preserved hepatic tissue.…”
Section: Introductionmentioning
confidence: 99%
“…Despite of being widely used in medical practice and experimental models of IR injury, the literature about the use of NAC in the treatment of hemorrhagic shock and its possible protective effect in cardiomyocytes is scarce. As satisfactory results were observed with the use of NAC as protective drug of lung and liver tissue in experimental studies with controlled hemorrhagic shock models [ 12 , 13 ] , as well as in other studies that used tissue IR injury models [ 14 - 16 ] , the aim of this study was to assess the possible cardioprotective effect of adding NAC to volume replacement solution after induction and maintenance of controlled hemorrhagic shock.…”
Section: Introductionmentioning
confidence: 99%