volume 27, issue 7, P477-481 2012
DOI: 10.1590/s0102-86502012000700008
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Abstract: ABSTRACT PURPOSE:To investigate the effect of lovastatin on renal ischemia followed by reperfusion. METHODS:Thirty one Wistar rats submitted to left renal ischemia for 60 minutes followed by contralateral nephrectomy were divided into two groups: A (n =17, control, no treatment), and B (n=14, lovastatin 15 mg/kg/day p.o. ten days before ischemia). The animals were sacrificed at the end of ischemia, after 24 hours and at seven days after reperfusion. Survival, serum urea and creatinine levels and renal mitocho…

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