Long-term effects of the testicular torsion on the spermatogenesis of the contralateral testis and the preventive value of the twisted testis orchiepididymectomy

Lorenzini, Fernando; Filho, Renato Tambara; Gomes, Regina Paula X.; Martino‐Andrade, Anderson Joel; Erdmann, Thomas Rolf; Matias, Jorge Eduardo Fouto

doi:10.1590/s0102-86502012000600006

Cited by 18 publications

(16 citation statements)

References 25 publications

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“…Spermatogenesis and male fertility have been extensively studied, and the factors that alter them, such as varicocele, torsion of the testis, and cryptorchidism, have already been the targets of numerous studies [16][17][18] . As a variable that affects all beings, aging has been the focus of various studies, which have indicated testicular changes and change in seminal quality with increasing age 4,11,19 .…”

Section: ■ Discussionmentioning

confidence: 99%

Stereological and morphological analysis of the effects of aging on spermatogenesis in rat testis

et al. 2018

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To quantify, through stereological and morphometric analysis, spermatogenesis in rats undergoing the natural aging process. Methods: Seventy-two male Wistar rats were divided into 6 equal groups according to age at the time of killing: 3, 6, 9, 12, 18, and 24 months. All the rats were subjected orchiectomy and collection of testicular parenchymal fragments for histological and morphometric analysis. The numerical density of spermatids was calculated using a stereological study, and morphometric analysis was conducted to measure the height of the germinal epithelium and the area of the seminiferous tubules. Results: We found that the 18 and 24 months groups showed a significant reduction in the number of round spermatids. However, the height of the germinal epithelium was not significantly different between the groups. The area of seminiferous tubules was also significantly reduced in the elderly rats compared to that in the young ones. Conclusion: Aging of rats showed a significant reduction in the number of round spermatids and the area of the seminiferous tubules, more pronounced in the rats at 18 and 24 months of life.

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Section: ■ Discussionmentioning

confidence: 99%

Stereological and morphological analysis of the effects of aging on spermatogenesis in rat testis

et al. 2018

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“…Another problem in testicles with Grade 3 damage, which underwent detorsion and orchiopexy, is that it may cause contralateral testicular damage and infertility in the late period owing to oxygen-free radicals and antisperm antibodies. 15,19 However, Lorenzini et al 20 stated that TT does not cause long-term effects on the spermatogenesis of the contralateral testis in pubertal rats. This situation is controversial.…”

Section: Discussionmentioning

confidence: 99%

Role of diffusion weighted magnetic resonance imaging in a rat model of testicular torsion

Ufuk

Herek²,

Herek³

et al. 2016

BJR

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“…[17] Aksine, testis torsiyonunun pubertal sıçanlarda kontralateral testiste spermatogenez üzerinde uzun sürede etki yapmadığı bildirilmiştir. [18] Çalışmamızda, torsiyone edilen sağ testis tunika albuginealarının doku bütünlüğünün korunduğu ve bone-wax çevresinde, protezi çepeçevre koruyan bir fibröz kapsül oluştuğu gözlendi. Her iki grupta da torsiyon oluşturulmamış olan sol testis dokularının histolojik değerlendirilmesinde Sertoli hücrelerinde, spermatogenetik aktivitede ve intersitisyel hücrelerde atrofi ya da dejenerasyon bulgusuna rastlanmamıştır.…”

Section: Gereç Ve Yöntemunclassified

Ratlarda gecikmiş testis torsiyon modelinde subkapsüler orşiyektomi sonrası protez olarak bone-wax implantasyonunun sonuçları

Bolat¹,

Büyükalpelli²,

Karagöz³

2019

Androl Bul

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OBJECTIVE: Classical orchiectomy, which is the only treatment option for delayed testicular torsion, causes serious psychosocial problems in men. Standard testicular prostheses to be implanted to minimize the impact of psychological trauma have high treatment costs. Because standard testicular prostheses cannot be stocked in the operating room, it is impossible to implant it during orchiectomy. Hence, these implants are placed with additional intervention. In this experimental rat model, during subcapsular orchiectomy, we investigated the results of implantation of ovoid-shaped bone-wax paraffin as a testicular prosthesis which could easily be reached almost every operating room. MATERIAL and METHODS: Mature male rats were randomized to two groups, each containing 15 animals. Three hundred and sixty-degree experimental right testicular torsion was applied in Group 1 rats and subsequently randomized to 1A, 1B and 1C subgroups according to their surgical detorsion time 12, 24 and 48 hours later, respectively. Similarly, 720-degree experimental right testicular torsion was applied in Group 2 rats and subsequently randomized to 2A, 2B and 2C subgroups according to their surgical detorsion time 12, 24 and 48 hours later, respectively. Necrotic testicular parenchyma was removed using the subcapsular orchiectomy technique in the groups, ovoid-shaped bone-wax was placed in the tunica albuginea. Thirty days later, bilateral orchiectomy was done all the rats and, specimens were physically and histopathologically examined. RESULTS: Regardless of the duration and degree of torsion, light microscopic examination showed minimal thickening, histiocytic reaction and rare foreign body granulation reaction in the tunica albuginea. Although parenchymal necrosis was detected, tunica albuginea was minimally affected with no serious foreign-body reaction. Bone-wax material mimicked the testis as a testicular prosthesis. CONCLUSION: This experimental study showed that, as an alternative to classical orchiectomy, the results of bone-wax paraffin implantation as a testicular prosthesis after subcapsular orchiectomy were found encouraging in delayed testicular torsion model.

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Long-term effects of the testicular torsion on the spermatogenesis of the contralateral testis and the preventive value of the twisted testis orchiepididymectomy

Cited by 18 publications

References 25 publications

Stereological and morphological analysis of the effects of aging on spermatogenesis in rat testis

Stereological and morphological analysis of the effects of aging on spermatogenesis in rat testis

Role of diffusion weighted magnetic resonance imaging in a rat model of testicular torsion

Ratlarda gecikmiş testis torsiyon modelinde subkapsüler orşiyektomi sonrası protez olarak bone-wax implantasyonunun sonuçları

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