Mechanical properties of radial bone defects treated with autogenous graft covered with hydroxyapatite in rabbit

Abstract

PURPOSE:To determine biomechanical property of autogenous bone graft covered with hydroxyapatite in the defect of radial bone in rabbit. METHODS: Eighteen adult male New Zealand white rabbits were used which were divided into three groups (I, II, III) of six rabbits each. A segmental bone defect of 10 mm in length was created in the middle of the right radial shaft under general effective anesthesia in all rabbits and were stabilized using mini-plate with four screws. The defects In group I were left as such without filler, whereas in group II the defect were filled up with harvested 10 mm rib bone and in group III the defect were packed with rib bone covered with nano-hydroxyapatite. All rabbits in three groups were divided into two subgroups (one month and three months duration with three rabbits in each one). RESULTS:The mechanical property and the mean load for fracturing normal radial bone was recorded 388.2±6 N whereas it was 72.4±12.8 N for group I in 1 month duration which was recorded 182.4±14.2 N for group II and 211.6±10.4 N for group III at the end of 1 month. These values were 97.6±10.2 N for group I and 324.6±8.2 N for group II and 372.6±17.4 N for group III at the end of three months after implantation. CONCLUSION: Implantation of autologous graft covered with hydroxyapatite indicated to have positive effect in integral formation of qualitative callus at the site of fracture and early re-organization of callus to regain mechanical strength too.

Retracted: Bone neoformation of a novel porous resorbable Si‐Ca‐P‐based ceramic with osteoconductive properties: physical and mechanical characterization, histological and histomorphometric study

“…, ,b) In view of this, the results in this study were enhanced through the creation of critical defects of 6‐mm diameter, which will not close spontaneously and therefore demonstrate the regenerative potential of the biomaterials under observation (Sharifi et al. ). No membranes were placed for an exclusive evaluation of the biological behavior of the biomaterial regarding critical defect.…”

“…Despite the New Zealand rabbit's rapid metabolic activity, other studies have established its validity as an experimental model for testing biomaterials used for bone replacement. (Calvo-Guirado et al 2014 In view of this, the results in this study were enhanced through the creation of critical defects of 6-mm diameter, which will not close spontaneously and therefore demonstrate the regenerative potential of the biomaterials under observation (Sharifi et al 2012). No membranes were placed for an exclusive evaluation of the biological behavior of the biomaterial regarding critical defect.…”

Retracted: Bone neo‐formation and mineral degradation of 4Bone.® Part II: histological and histomorphometric analysis in critical size defects in rabbits

“…In view of this, the results in this study were enhanced through the creation of critical defects of 6 mm diameter, which will not close spontaneously and therefore demonstrate the regenerative potential of the biomaterials under observation (Sharifi et al. ).…”

Influence of hydroxyapatite granule size, porosity, and crystallinity on tissue reaction in vivo. Part A: synthesis, characterization of the materials, and SEM analysis

“…Despite the New Zealand rabbit's rapid metabolic activity, other studies have established its validity as an experimental model for testing biomaterials used for bone replacement (Calvo-Guirado et al 2012). In view of this, the results in this study were enhanced through the creation of critical defects of 6 mm diameter, which will not close spontaneously and therefore demonstrate the regenerative potential of the biomaterials under observation (Sharifi et al 2012).…”