Intestinal healing in rats submitted to ethanol ingestion

Pereira, Rodrigo Severo de Camargo; Hasimoto, Cláudia Nishida; Pelafsky, Leonardo; Llanos, Juan Carlos; Catâneo, Daniele Cristina; Spadella, César Tadeu; Minossi, José Guilherme

doi:10.1590/s0102-86502012000300006

Cited by 6 publications

(8 citation statements)

References 47 publications

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“…Both alcohol and sepsis are known to lead to weight loss after surgery, and their combination diminished the post-operative body mass in this study, and even at the 7 POD that weight wasn’t recovered [13,14]. Sepsis leads to a consumptive syndrome due to the inflammation and alcohol intake is responsible for malnutrition because of intestinal malabsorption and is also responsible for body fat reduction [13,14].…”

Section: Discussionmentioning

confidence: 88%

Alcohol acute intoxication before sepsis impairs the wound healing of intestinal anastomosis: rat model of the abdominal trauma patient

et al. 2012

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IntroductionMost trauma patients are drunk at the time of injury. Up to 2% of traumatized patients develop sepsis, which considerably increases their mortality. Inadequate wound healing of the colonic repair can lead to postoperative complications such as leakage and sepsis.ObjectiveTo assess the effects of acute alcohol intoxication on colonic anastomosis wound healing in septic rats.MethodsThirty six Wistar rats were allocated into two groups: S (induction of sepsis) and AS (alcohol intake before sepsis induction). A colonic anastomosis was performed in all groups. After 1, 3 or 7 days the animals were killed. Weight variations, mortality rate, histopathology and tensile breaking strength of the colonic anastomosis were evaluated.ResultsThere was an overall mortality of 4 animals (11.1%), three in the group AS (16.6%) and one in the S group (5.5%). Weight loss occurred in all groups. The colon anastomosis of the AS group didn’t gain strength from the first to the seventh postoperative day. On the histopathological analysis there were no differences in the deposition of collagen or fibroblasts between the groups AS and S.ConclusionAlcohol intake increased the mortality rate three times in septic animals. Acute alcohol intoxication delays the acquisition of tensile strength of colonic anastomosis in septic rats. Therefore, acute alcohol intoxication before sepsis leads to worse prognosis in animal models of the abdominal trauma patients.

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Section: Discussionmentioning

confidence: 88%

Alcohol acute intoxication before sepsis impairs the wound healing of intestinal anastomosis: rat model of the abdominal trauma patient

et al. 2012

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“…Pereira et al 9 has shown that a model of chronic alcohol abuse in rats is associated with lower weight gain, impaired intestinal healing (as demonstrated by significantly lower bowel anastomosis breaking strength), and higher postoperative complication rates.…”

Section: Discussionmentioning

confidence: 99%

“…We hypothesized that acute alcohol exposure shortly before surgery would be a risk factor for impaired wound healing of the colonic anastomosis, based on results from other experimental studies [9][10][11][12] . However, in those studies, alcohol exposure followed different patterns.…”

Section: Introductionmentioning

confidence: 99%

Does acute alcohol intoxication interfere with colonic anastomosis wound healing?: a rat model of nondestructive colon trauma

Morais¹,

Farias²,

Ribeiro³

et al. 2013

Acta Cir. Bras.

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PURPOSE:To evaluate the effects of acute alcohol intoxication on healing of colonic anastomosis. METHODS: Thirty-six rats were allocated into two groups. Animals in the alcohol (A) were given 2 mL of ethanol diluted in 0.9% saline solution to a concentration of 40% by gavage immediately before anesthesia, whereas control (C) animals received 2 mL of 0.9% saline solution via the same route. A colonic anastomosis was then performed in all animals. On postoperative days 1, 3, and 7, anastomotic breaking strength was assessed and histopathological examination was performed. Change in body weight and mortality were also evaluated. RESULTS:The median of anastomotic tensile strength on the postoperative day 1 was 0.09 Newtons for group A and 0.13 for group C. (p>0.05). The median of anastomotic tensile strength on the postoperative day 3 was 0.13 Newtons for group A and 0.17 for group C. (p>0.05). The median of anastomotic tensile strength on the postoperative day 7 was 0.30 Newtons for group A and 0.35 for group C. (p>0.05). There was no significant difference between the groups A and C, in the first, third or seventh POD (p>0.05), in any of the analyzed parameters. There were no statistical differences between groups in the weight. Three animals died, all from the group A. CONCLUSION:Acute alcohol intoxication did not interfere with wound healing of colonic anastomoses, although it caused early postoperative mortality.

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“…Otros efectos deletéreos de la ingestión crónica de alcohol incluyen la desnutrición, hipotermia, dsiminución de la función y número de plaquetas, induciendo la reducción del fibrinógeno y, consecuentemente, el compromiso de la cicatrización de la herida (17) . Estudio reciente, con el objetivo de evaluar el efecto del alcoholismo en el proceso de cicatrización intestinal y sus complicaciones postoperatorias en ratones, evidenció que, en el grupo tratado con etanol a 30%, ocurrió mayor número de complicaciones postoperatorias, proceso de desnutrición, empeoramiento en la cicatrización intestinal y mayor incidencia de muertes (18) .…”

Section: Enfermería Globalunclassified

Tricotomía preoperatoria: aspectos relacionados con la seguridad del paciente

Gebrim

Melchior

Amaral

et al. 2014

eglobal

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RESUMENEl objetivo del estudio fue analizar los indicadores del proceso de Rasurado en cirugías limpias, en un hospital universitario del Centro-Oeste brasileño. Se trata de un estudio retrospectivo, de corte transversal, analítico. Se analizaron 700 historias clínicas de pacientes sometidos a cirugía limpia, de 2008 a 2010. Evidenció que, 27% (189) los pacientes fueron rasurados y 15,9% desarrolló infección del sitio quirúrgico, dato mayor que el encontrado en la literatura, se asume una tasa de entre 1 y 5%. Entre los indicadores de proceso relacionados al rasurado, 82,5% se realizaron hasta 2 horas antes de la incisión de la piel, 16,9% usaron una cuchilla de afeitar, el método estándar que se utiliza en el servicio y 83,1% de los registros, no había constancia del método utilizado para este procedimento. Se concluyó que el método de eliminación del vello mostró desacuerdo con los principios de funcionamiento seguro, siendo este un fuerte predictor de la tasa de infección encontrada en el estudio. RESUMOO estudo objetivou analisar o indicador de processo Tricotomia em cirurgias limpas em um hospital de ensino do Centro-Oeste brasileiro. Trata-se de estudo retrospectivo do tipo transversal, de natureza

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Intestinal healing in rats submitted to ethanol ingestion

Cited by 6 publications

References 47 publications

Alcohol acute intoxication before sepsis impairs the wound healing of intestinal anastomosis: rat model of the abdominal trauma patient

Alcohol acute intoxication before sepsis impairs the wound healing of intestinal anastomosis: rat model of the abdominal trauma patient

Does acute alcohol intoxication interfere with colonic anastomosis wound healing?: a rat model of nondestructive colon trauma

Tricotomía preoperatoria: aspectos relacionados con la seguridad del paciente

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