2011
DOI: 10.1590/s0102-86502011000700009
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Abstract: Trauma by severance of thigh muscles in healthy rats is a simple and efficient model to induce distant lung lesions.

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Cited by 3 publications
(2 citation statements)
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“…In this experimental study, it was found that injecting dexamethasone into ARDS rats via the caudal vein could significantly alleviate the body's inflammatory response in ARDS rats, and maintain the balance between anti-inflammatory response and inflammatory response, thereby reducing inflammatory exudation of lung tissues and pulmonary edema, and protecting the lung. Glucocorticoids have a wide range of mechanisms of action in the treatment of ARDS, which can directly or indirectly act on inflammatory cells, reduce myeloperoxidase activity, and inhibit neutrophil activation, thereby alleviating tissue damage (26). At the same time, glucocorticoids can promote the expression of mitogen-activated protein kinase phosphatase-1 in lung tissues, and inhibit expression levels of neutrophil chemokine, monocyte chemoattractant protein-1 and P-selectin, thereby reducing the inflammatory response in lung tissues (27).…”
Section: Discussionmentioning
confidence: 99%
“…In this experimental study, it was found that injecting dexamethasone into ARDS rats via the caudal vein could significantly alleviate the body's inflammatory response in ARDS rats, and maintain the balance between anti-inflammatory response and inflammatory response, thereby reducing inflammatory exudation of lung tissues and pulmonary edema, and protecting the lung. Glucocorticoids have a wide range of mechanisms of action in the treatment of ARDS, which can directly or indirectly act on inflammatory cells, reduce myeloperoxidase activity, and inhibit neutrophil activation, thereby alleviating tissue damage (26). At the same time, glucocorticoids can promote the expression of mitogen-activated protein kinase phosphatase-1 in lung tissues, and inhibit expression levels of neutrophil chemokine, monocyte chemoattractant protein-1 and P-selectin, thereby reducing the inflammatory response in lung tissues (27).…”
Section: Discussionmentioning
confidence: 99%
“…), NO plays an important role affecting the processes of their maturation, differentiation, proliferation and apoptosis [12][13][14][15]. According to the literature data [5,[16][17][18][19][20], NO produces an active effect on: -selection and maturation of T-lymphocytes in the thymus; -lymphocyte migration and recirculation and balance of the population-clonal composition; -maintaince of the T-helper-suppressor balance; -thymus age involution; -IFNγ production by NK-cells and support of their cytolytic properties; -decrease/increase of cytokines synthesis resulting in stimulation/inhibition of cytotoxic function of immunocompetent cells] [21,22]. Nowadays the question of synthesis of NOS isoforms by primary T-and B-lymphocytes is still open [23][24][25].…”
Section: Introductionmentioning
confidence: 99%