Preconditioning with oil mixes of high ratio Omega-9: Omega-6 and a low ratio Omega-6:Omega-3 in rats subjected to brain ischemia/reperfusion

Pinheiro, Petrúcia Maria Antero; Campelo, Ana Paula Bomfim Soares; Guimarães, Sérgio Botelho; Patrocínio, Régia Maria Vidal do; Valença, José Telmo; Vasconcelos, Paulo Roberto Leitão de

doi:10.1590/s0102-86502011000700007

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…Pinheiro and cols in 2011, have shown that the preconditioning of 42 male rats with different omega oil mix preparations promoted protection against the deleterious effects of ischemia/reperfusion injury demonstrated by the reduction of red neurons in the group that received mix 2 (omega 6: omega 3 ratio-1.4:1; omega 9: omega 6 ratio-3.4:1) source of omega 3 ALA (35%) + EPA (39%) + DHA (26%) [39].…”

Section: Use Of Omega 3 6 and 9 In Brain Ischemia Animal Modelsmentioning

confidence: 99%

The Pathophysiological Aspects of Cerebral Diseases

Silva¹,

Maia²,

Vasconcelos³

et al. 2022

Cerebrovascular Diseases - Elucidating Key Principles

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Introduction. Cerebrovascular disorders are the main causes of heavy burden health worldwide, also, it is critical to understand the pathophysiological mechanism and then trying to prevent the neurological sequels. Objective. To discuss the inflammatory and oxidative stress aspects associated to the cerebrovascular diseases, focusing on biomarkers, also the role of omega oils, and the intracellular molecular network associated to the tissue burden on those conditions. Results. One of the most promising biomarkers it is Neuron-Specific Enolase (NSE). Serum NSE levels were elevated in stroke-patients compared to the non-stroke controls. Also, studies have demonstrated that in specific ratio omega oils 3, 6 and 9 can ameliorate the inflammatory and oxidative stress in nervous tissue and could be useful to the inflammatory and oxidative stress negative effects of cerebrovascular diseases. In addition, the study of the molecular mechanisms is essential to understand which molecules could be addressed in cascade of events preventing the permanent damage on the nervous tissue. Final considerations. The studies on cerebrovascular disorders must precisely identify the mechanisms and key molecules involved and improve the time of diagnostics and prognostics reducing the negative impacts of those conditions.

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Section: Use Of Omega 3 6 and 9 In Brain Ischemia Animal Modelsmentioning

confidence: 99%

The Pathophysiological Aspects of Cerebral Diseases

Silva¹,

Maia²,

Vasconcelos³

et al. 2022

Cerebrovascular Diseases - Elucidating Key Principles

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“…Preconditioning aims to prepare the host to a future lesion either by decreasing the intensity of its response or by inducing resilience of the organism towards the biological challenge to happen 1 . Various experimental and clinical studies have provided evidence of the preconditioning effects of the dipeptide l-alanyl-glutamine (L-Ala-Gln).…”

Section: Introductionmentioning

confidence: 99%

Preconditioning with L-alanyl-glutamine upon cerebral edema and hypocampus red neurons counting in rats subjected to brain ischemia /reperfusion injury

Vasconcelos

Guimarães²,

Campelo³

et al. 2015

Acta Cir. Bras.

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Conception, design, intellectual and scientific content of the study, critical revision, final approval. ABSTRACT PURPOSE:To evaluate the effects of the dipeptide L-alanyl-glutamine (L-Ala-Gln) as a preconditioning agent to potentially promote reduction in the intensity of lesion or induction of resilience in rats subjected to global cerebral ischemia/reperfusion (I/R) injury. METHODS:Thirty-six male Wistar rats weighing 280-300g were randomly assigned to six groups (n=6). Groups Sham 1h and 24hwere treated with saline and spared of further interventions. The remaining groups were submitted to clamping of the common carotid arteries for 30 minutes (ischemia) and treated with saline (SS) or L-Ala-Gln. Brain reperfusion was allowed for 1or 24 h. L-Ala-Gln was administered intravenously (0.75g/kg) 30 minutes before sham procedure or induction of global brain I/R injury. Brain edema and red neuron counting were determined. Results were expressed as Mean±SD for normal results and Median±Percentile for non parametric data. Significance was established at p<0.05. RESULTS:Global I/R injury promoted an increase in brain edema at 24 h after reperfusion, whereas preconditioning with L-Ala-Gln induced no change in edema. On the other hand, L-Ala-Gln preconditioning decreased significantly red neurons counting both at 1h and 24h post reperfusion (p<0.05). CONCLUSION:There was a significant preconditioning effect with L-Ala-Gln decreasing cell death (red neurons counting) at early (1h) and late reperfusion (24h) in the cerebral tissue.

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“…Pinheiro et al 5 investigated the effects of pre-conditioning with mixtures of oils containing high and low ratio ω-6/ω-3 and ω-9/ω-6…”

Section: Introductionmentioning

confidence: 99%

Antiperoxidative properties of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 after molar extraction in rats

Melo

Guimarães²,

Silva³

et al. 2014

Acta Cir. Bras.

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Brazil. Conception, design, intellectual and scientific content of the study; critical analysis, final approval of the manuscript. ABSTRACT PURPOSE:To evaluate the antioxidant and antiperoxidative effects of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 in the third day after tooth extraction in rats. METHODS:Thirty-two male Wistar rats (270-310g) were randomly distributed in two groups: Control (n=24) and Test (n=8). Control group was divided into three subgroups (n=8): G1: Sham-Saline; G2: Saline; G3: Isolipid. G1 and G2 animals received NaCl 0.9% while G3 rats were treated with an isolipid mixture (alpha-linolenic acid -ALA) containing -6/-3 oils (8:1 ratio) and-9/-6 (0.4:1 ratio). Test group animals (G4) received oily mixtures (alpha-linolenic acid -ALA, docosahexaenoic acid -DHA, eicosapentaenoic acid -EPA) of -6/-3 (1.4:1 ratio) and -9/-6 (3.4:1 ratio). Saline and oils were administered by gavage during four days before and three days after first mandibular molar extraction. Following, samples (arterial blood and alveolar mucosa) were collected for glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) assays. RESULTS:Oil mixes induced a significant decrease in GSH and TBARS tissue and plasma concentrations in the third day post-surgery. CONCLUSION:Gavage administration of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 after molar extraction in rats induces a significant decrease in lipid peroxidation.

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Preconditioning with oil mixes of high ratio Omega-9: Omega-6 and a low ratio Omega-6:Omega-3 in rats subjected to brain ischemia/reperfusion

Cited by 4 publications

References 27 publications

The Pathophysiological Aspects of Cerebral Diseases

The Pathophysiological Aspects of Cerebral Diseases

Preconditioning with L-alanyl-glutamine upon cerebral edema and hypocampus red neurons counting in rats subjected to brain ischemia /reperfusion injury

Antiperoxidative properties of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 after molar extraction in rats

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