2011
DOI: 10.1590/s0102-86502011000600011
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Abstract: PURPOSE:To evaluate the mitochondrial function of the remnant liver (RL) in the early phase of liver regeneration in rats after 70% partial hepatectomy (PH). METHODS: Sixty male Wistar rats (200-250g) submitted to 70% PH were divided into five groups according to the time of euthanasia and application or not of laser light: C = Control, time zero; 2 minutes, 4, 6 and 24 hours after PH. The dose of laser radiation was 22.5 J/cm 2 , wavelength of 660 nm (visible/red), in the remnant liver. We studied the respira… Show more

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Cited by 7 publications
(13 citation statements)
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“…[15][16][17] In a recent study, Barbosa and colleagues observed that 24 hours after laser exposure have already observed an important increase in ATP production. 18 In sum, these studies demonstrated that both high-and low-power lasers have the ability to increase the mitotic index and mitochondrial function in the remaining liver after different levels of partial resection (70% and 90%) in rats. [15][16][17][18][19] In addition, Oron et al, 20 in analyzing other parameters, demonstrated the effects of LPLI on liver regeneration in rats subjected to a 70% hepatectomy.…”
Section: New Road -The Low-power Laser Irradiationmentioning
confidence: 71%
See 1 more Smart Citation
“…[15][16][17] In a recent study, Barbosa and colleagues observed that 24 hours after laser exposure have already observed an important increase in ATP production. 18 In sum, these studies demonstrated that both high-and low-power lasers have the ability to increase the mitotic index and mitochondrial function in the remaining liver after different levels of partial resection (70% and 90%) in rats. [15][16][17][18][19] In addition, Oron et al, 20 in analyzing other parameters, demonstrated the effects of LPLI on liver regeneration in rats subjected to a 70% hepatectomy.…”
Section: New Road -The Low-power Laser Irradiationmentioning
confidence: 71%
“…18 In sum, these studies demonstrated that both high-and low-power lasers have the ability to increase the mitotic index and mitochondrial function in the remaining liver after different levels of partial resection (70% and 90%) in rats. [15][16][17][18][19] In addition, Oron et al, 20 in analyzing other parameters, demonstrated the effects of LPLI on liver regeneration in rats subjected to a 70% hepatectomy. Two days after the surgery and laser exposure, it was observed that the remaining liver had increased the newly formed blood vessels determined by 5-Bromo-2´deoxyuridine (BrdU immunostaining), as well as, had augmented the number of bone-marrow-derived mesenchymal stem cells (MSCs) determined by c-kit immunostaining.…”
Section: New Road -The Low-power Laser Irradiationmentioning
confidence: 71%
“…Studies have described the relationship between wavelength and its effect on oxidative stress in animals not submitted to operative or chemical interventions, finding little or no difference between groups of different wavelengths. In general, the laser obtained positive results in the tangent to the reduction of oxidative stress [41][42][43] . Its use is then focused on hepatocellular protection during the IR lesion.…”
Section: Laser Therapymentioning
confidence: 93%
“…Recently, an important review demonstrated that lowpower laser irradiation (LPLI), particularly red and near infrared light, plays an important role by inducing regeneration in various tissues, especially by stimulating cell proliferation [10]. LPLI has been presented as a simple, easy, safe, and effective adjunctive tool for improving the capacity of liver regeneration [11][12][13][14][15][16]. A recent study by our group demonstrated the main molecular mechanisms associated with the abovementioned effect, since it demonstrated that LPLI acts by increasing hepatocyte growth factor (HGF) protein expression and the phosphorylation levels of Met, Akt and Erk 1/2, accompanied by higher levels of proliferating cell nuclear antigen (PCNA) and Ki-67 (established proliferating markers) in the remnant liver of partially hepatectomized rats [16].…”
Section: Introductionmentioning
confidence: 99%