Gel from unripe Musa sapientum peel to repair surgical wounds in rats

Atzingen, Dênia Amélia Novato Castelli Von; Gragnani, Alfredo; Veiga, Daniela Francescato; Abla, Luis Eduardo Felipe; Mendonça, Adriana Rodrigues dos Anjos; Paula, Clayton Aparecido de; Juliano, Yára; Corrêa, J. C.; Faria, Marcio Raimundo de; Ferreira, Lydia Masako

doi:10.1590/s0102-86502011000500009

Cited by 12 publications

(15 citation statements)

References 9 publications

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“…This may be inferred by comparing the evolution of the wounds at different time points (i.e., at 14, 21 and 28 days of treatment). Other study has evaluated the effect of unripe banana peel gel at a different time interval 1 , suggesting that our findings may also be relevant to the treatment of chronic wounds. Further studies are necessary to confirm the beneficial effects of this gel and extend our results.…”

Section: Histological Analysismentioning

confidence: 83%

“…The gel concentration was chosen based on a previous study, in which the 10% gel resulted in epithelialization of wounds healed by secondary intention 1 .…”

Section: Histological Analysismentioning

confidence: 99%

“…This condition is associated with several diseases and imposes a major social and economic burden on patients and healthcare systems. Thus, the search for alternative therapies for the management of chronic wounds is of fundamental importance 1,2 . There are many treatment options for chronic wounds on the market, but it has been difficult to properly determine the cost-benefit relationship and best treatment option for each type of Further studies are being conducted by this research team.…”

Section: Introductionmentioning

confidence: 99%

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Repair of surgical wounds in rats using a 10% unripe Musa sapientum peel gel

et al. 2015

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PURPOSE:To investigate the efficacy of a 10% gel of unripe banana (Musa sapientum) peel in treating surgical wounds in rats. METHODS:A longitudinal, prospective, randomized triple-blind study was conducted with 60 Wistar rats (Rattus norvegicus albinus) weighing approximately 400g. The animals were randomly divided into: control group (treated with gel containing no active ingredient) and study group (treated with 10% gel of unripe banana peel). The gel was applied every three days to a 4x4-cm surgical wound created on the back of each animal (day 0) in both groups. Tissue samples were collected for histological analysis on days 14, 21 and 28. RESULTS:On day 14, more extensive vascular proliferation (p=0.023), presence of mononuclear cells (p=0.000), fibroblast proliferation (p=0.012), re-epithelialization (p=0.000), and decreased presence of polymorphonuclear cells (p=0.010) were observed in the study group than in controls. No significant between-group difference in the presence of polymorphonuclear cells was found on day 21.Fibroblast proliferation was significantly greater (p=0.006) in the study group than in the control group on day 28. CONCLUSION:The 10% gel of unripe banana peel showed anti-inflammatory activity and stimulated wound healing in rat skin when compared with a gel containing no active ingredient.

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Section: Histological Analysismentioning

confidence: 83%

“…The gel concentration was chosen based on a previous study, in which the 10% gel resulted in epithelialization of wounds healed by secondary intention 1 .…”

Section: Histological Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Repair of surgical wounds in rats using a 10% unripe Musa sapientum peel gel

et al. 2015

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“…Banana peel is also rich in flavonoids, such as galocatechin and isocyanidine, substances that have anti-inflammatory and antineoplastic activity. Thus, it can play a role in the prevention of inflammatory processes, dissemination of bacteria and tissue repair in animals (Atzingen et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

<b>Cheese and milk quality of F1 Holstein x Zebu cows fed different levels of banana peel

Melo

Júnior

Caldeira

et al. 2017

Acta Sci. Anim. Sci.

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ABSTRACT. This study aimed to evaluate the effects of the inclusion of different levels of sun-dried banana peel in the diet for crossbred cows on the quality of Minas fresh cheese and milk. Diets consisted of 0, 15, 30, 45 and 60% replacement of sorghum silage with banana peel. Ten cows were assigned to two 5 x 5 Latin squares experimental design. Milk samples were taken from each cow and analyzed for composition. Milk was pasteurized for the production of Minas fresh cheese, which was weighed to determine the yield and analyzed for texture, physical and chemical characteristics and consumer acceptance test. Milk urea nitrogen had a quadratic effect with minimum point at 43.76% replacement of silage with banana peel. The remaining items evaluated in the composition of milk and cheese and the consumer acceptance test were not influenced by diets with banana peel. The replacement of up to 60% sorghum silage with banana peel is a viable alternative because it causes no alteration in physical and chemical composition of milk and Minas fresh cheese, as well as consumer acceptance.Keywords: banana crop, milk processing, by-products.Qualidade do queijo e do leite de vacas F1 Holandês x Zebu alimentadas com níveis de casca de banana RESUMO. Objetivou-se avaliar os efeitos dos níveis de inclusão da casca de banana seca ao sol na dieta de vacas mestiças sobre a qualidade do queijo Minas frescal e do leite. As dietas foram constituídas de 0, 15, 30, 45 e 60% de substituição da silagem de sorgo pela casca de banana. Foram utilizadas 10 vacas em um delineamento experimental com dois quadrados latinos 5 x 5. Amostras de leite de cada vaca foram analisadas quanto à composição. O leite foi pasteurizado para fabricação do queijo Minas Frescal, que foi pesado para determinação do rendimento e analisado para textura, características físico-químicas e teste de aceitação geral pelo consumidor. O nitrogênio uréico do leite apresentou efeito quadrático com ponto de mínimo ao nível de 43,76% de substituição da silagem pela casca de banana. Os demais itens avaliados na composição do leite e do queijo, bem como os testes de aceitação geral pelo consumidor, não sofreram influência das dietas com inclusão de casca de banana. A substituição de até 60% da silagem de sorgo por casca de banana pode ser uma alternativa viável, pois não altera a composição físico-química do leite e do queijo Minas Frescal, bem como aceitação deste pelos consumidores.Palavras-chave: bananicultura, processamento do leite, subprodutos.

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“…Thus, in Brazil, its sap is used for treatment of bleeding (Albuquerque et al, 2007). The aqueous extract of the fruit of Musasapientum is used in India for the treatment of wounds (Agarwal et al, 2009;Atzingen, 2011). A species of the same genus (Musa paradisiaca L.) was reported in Brazil for the same properties (Borges et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Hemostatic potential of the sap of Musa sapientum L. (Musaceae)

Klotoe¹

2012

J. App. Pharm. Sci.

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In Benin, Musa sapientum is one of the most important medicinal species used in the treatment of bleeding. In this study, hemostatic properties of M. sapientium sapand its mechanism of action have been identified through hematologic tests such as Clotting Time, Prothrombin Time, Activated Partial Thromboplastin Time and Milk Precipitation Test; biochemical test (total proteins); macroscopic and microscopic tests performed on different blood products before and after addition of sap. The results obtained showed that Musa sapientum reduced significantly clotting Time. However, it has no effect on the individual factors of coagulation. Its mechanism of action results from its ability to form a protein network which is a basis for cellular aggregation stopping bleeding. Moreover, Milk Precipitation Test showed astringent properties of Musa sapientum and therefore its vasoconstrictors properties. Phytochemical analyses revealed the presence of alkaloids, tannins, coumarins, reducing compounds, anthocyanins and leucoantocyanes. . M. sapientumis great on treatment of bleeding and could help to elaborate new drugs.

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Gel from unripe Musa sapientum peel to repair surgical wounds in rats

Cited by 12 publications

References 9 publications

Repair of surgical wounds in rats using a 10% unripe Musa sapientum peel gel

Repair of surgical wounds in rats using a 10% unripe Musa sapientum peel gel

<b>Cheese and milk quality of F1 Holstein x Zebu cows fed different levels of banana peel

Hemostatic potential of the sap of Musa sapientum L. (Musaceae)

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