Evaluation of castor oil-based polyurethane membranes in rat bone-marrow cell culture

Cerejo, Sofia de Amorim; Rahal, Sheila Canevese; Neto, João Ferreira de Lima; Voorwald, Fabiana Azevedo; Alvarenga, Fernanda da Cruz Landim e

doi:10.1590/s0102-86502011000500002

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Therefore, CO can be used directly as a starting material for the preparation of polyurethanes, polyesters, polyamides, epoxy resins, and alkyd resins . Owing to their significant biocompatibility, vegetable oil‐based polyurethanes found interesting applications in biomedical area such as drug delivery systems, bone tissue engineering, bioadhesives, and wound dressing …”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of novel antibacterial castor oil-based polyurethane membranes for wound dressing application

Yari

Yeganeh

Bakhshi

et al. 2013

J. Biomed. Mater. Res.

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Preparation of novel antibacterial and cytocompatible polyurethane membranes as occlusive dressing, which can provide moist and sterile environment over mild exudative wounds is considered in this work. In this regard, an epoxy-terminated polyurethane (EPU) prepolymer based on castor oil and glycidyltriethylammonium chloride (GTEAC) as a reactive bactericidal agent were synthesized. Polyurethane membranes were prepared through cocuring of EPU and different content of GTEAC with 1,4-butane diamine. The physical and mechanical properties, as well as cytocompatibility and antibacterial performance of prepared membranes were studied. Depending on their chemical formulations, the equilibrium water absorption and water vapor transmission rate values of the membranes were in ranges of 3-85% and 53-154g m(-2) day(-1), respectively. Therefore, these transparent membranes can maintain for a long period the moist environment over the wounds with low exudates. Detailed cytotoxicity analysis of samples against mouse L929 fibroblast and MCA-3D keratinocyte cells showed good level of cytocompatibility of membranes after purification via extraction of residual unreacted GTEAC moieties. The antibacterial activity of the membranes against Escherichia coli and Staphylococcus aureus bacteria was also studied. The membrane containing 50% GTEAC exhibited an effective antibacterial activity, while showed acceptable cytocompatibility and therefore, can be applied as an antibacterial occlusive wound dressing.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of novel antibacterial castor oil-based polyurethane membranes for wound dressing application

Yari

Yeganeh

Bakhshi

et al. 2013

J. Biomed. Mater. Res.

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Castor oil-based polyurethane coatings containing benzyl triethanol ammonium chloride: synthesis, characterization, and biological properties

et al. 2014

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Evaluation of castor oil-based polyurethane membranes in rat bone-marrow cell culture

Abstract: Both Ficoll-Hypaque densities allow isolation of rat MSCs, and especially castor oil-based membrane type 3 may be used as a scaffold for MSCs.

Cited by 2 publications

References 13 publications

Preparation and characterization of novel antibacterial castor oil-based polyurethane membranes for wound dressing application

Preparation and characterization of novel antibacterial castor oil-based polyurethane membranes for wound dressing application

Castor oil-based polyurethane coatings containing benzyl triethanol ammonium chloride: synthesis, characterization, and biological properties

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