2011
DOI: 10.1590/s0102-86502011000400006
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Abstract: PURPOSE: To evaluate the effects of increased intraperitoneal pressure caused by carbon dioxide pneumoperitoneum on the hepatic and renal morphology of rats. METHODS: Fifty-four adult male rats were randomly divided into three groups (P, PP and C) after anesthesia: P - in 18 animals, pneumoperitoneum was established for 30 minutes immediately before laparotomy; PP - in 18 animals, pneumoperitoneum was established for 60 minutes divided into 30 immediately before laparotomy and 30 after abdominal closure; contr… Show more

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Cited by 8 publications
(8 citation statements)
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“…Another limitation of the experiment was the relatively short duration of PP (90 minutes). Some studies employed longer periods (as long as 24h 16 from immediately after PP 13,16 to some hours 11 , days 15 and even a year after PP 14 . Only one study has reported transient changes directly related to the insufflation pressure applied 16 , whereas all other investigations have failed to observe any significant histopathological changes 11,[13][14][15][16] .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Another limitation of the experiment was the relatively short duration of PP (90 minutes). Some studies employed longer periods (as long as 24h 16 from immediately after PP 13,16 to some hours 11 , days 15 and even a year after PP 14 . Only one study has reported transient changes directly related to the insufflation pressure applied 16 , whereas all other investigations have failed to observe any significant histopathological changes 11,[13][14][15][16] .…”
Section: Discussionmentioning
confidence: 99%
“…Histopathological changes have also been assessed, although they are reported only occasionally in the literature 2,4,11,[13][14][15][16] .…”
Section: Introductionmentioning
confidence: 99%
“…The rats receive the standard diet with water ad libitum [10][11][12] . All the rats passed by the same operatory procedure.…”
Section: Methodsmentioning
confidence: 99%
“…When tissues received by TUNEL method used for evaluating apoptosis are looked at, the result does not show significant difference although the apoptosis value in pneumoperitoneum + theophylline group is lower than pneumoperitoneum group. In an experimental study performed by Farias et al, 26 similarly, they did not encounter significant alterations in the examination with hematoxylin eosin in renal tissues received from the rats where pneumoperitoneum was applied. In another study, moderate hydropic degeneration and congestion were observed in both kidneys between the control group and the group where pneumoperitoneum was performed in the histopathological examination, but no significant difference detected.…”
mentioning
confidence: 86%