Grape extract and α-Tocopherol effect in cardiovascular disease model of Apo E -/- Mice

Pelúzio, Maria do Carmo Gouveia; Teixeira, Tatiana Fiche Salles; Oliveira, Vanessa Patrocínio de; Sabarense, Céphora Maria; Dias, Cristina Maria Ganz Chaves; Abranches, Monise Viana; Maldonado, Izabel Regina dos Santos Costa

doi:10.1590/s0102-86502011000400002

Cited by 11 publications

(14 citation statements)

References 36 publications

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“…To develop this point further, it would be interesting to analyse some results on effects of polyphenolic extracts in animals. For example, it has been shown that the grape extract treatment of mice did not alter the serum and liver levels of polyphenols (Peluzio Mdo et al., ). It has also been shown that inclusion of Camelina meal at 2.5%, 5% and 10% increased phenolic compounds in the diet by 28.4, 31.7 and 46.4% (Aziza et al., ,b).…”

Section: Polyphenol Effects In Poultry and Farm Animalsmentioning

confidence: 99%

Polyphenol compounds in the chicken/animal diet: from the past to the future

Surai

2013

Animal Physiology Nutrition

212

186

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SummaryAnimal feed provides a range of antioxidants that help the body building an integrated antioxidant system responsible for a prevention of damaging effects of free radicals and products of their metabolism. Vitamin E is considered to be the main chain-breaking antioxidant located in the membranes and effectively protecting them against lipid peroxidation. Recently, various polyphenol compounds, especially flavonoids, have received substantial attention because of their antioxidant activities in various in vitro systems. However, it was shown that flavonoid compounds are poorly absorbed in the gut and their concentrations in target tissues are too low to perform an effective antioxidant defences. The aim of the present paper is to review existing evidence about possible roles of various plant extracts provided with the diet in animal/poultry nutrition with a specific emphasis to their antioxidant activities.

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Section: Polyphenol Effects In Poultry and Farm Animalsmentioning

confidence: 99%

Polyphenol compounds in the chicken/animal diet: from the past to the future

Surai

2013

Animal Physiology Nutrition

212

186

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“…In apoE −/− mice without CKD, 6 weeks of α ‐tocopherol supplementation at 800 mg/kg diet has been shown to reduce aortic lesion area by 55%, despite no reduction in serum cholesterol or improvements in lipoprotein profile . In another study, apoE −/− mice on an atherogenic diet supplemented with 400 mg of α ‐tocopherol/kg diet had a reduction in the proportion of advanced aortic lesions compared to control apoE −/− mice . One study in patients with metabolic syndrome investigated the effects on α ‐, γ ‐, or combined‐tocopherol supplementation and suggested that a combination was superior in reducing inflammatory marker CRP .…”

Section: Discussionmentioning

confidence: 99%

Effect of Tocopherol on Atherosclerosis, Vascular Function, and Inflammation in Apolipoprotein E Knockout Mice with Subtotal Nephrectomy

Shing

Fassett

Peake

et al. 2014

Cardiovascular Therapeutics

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Summary Background/Aims Inflammation and endothelial dysfunction contribute to cardiovascular disease, prevalent in chronic kidney disease (CKD). Antioxidant supplements such as tocopherols may reduce inflammation and atherosclerosis. This study aimed to investigate the effect of tocopherol supplementation on vascular function, aortic plaque formation, and inflammation in apolipoprotein E−/− mice with 5/6 nephrectomy as a model of combined cardiovascular and kidney disease. Methods Nephrectomized mice were assigned to a normal chow diet group (normal chow), a group receiving 1000 mg/kg diet of α‐tocopherol supplementation or a group receiving 1000 mg/kg diet mixed‐tocopherol (60% γ‐tocopherol). Results Following 12 weeks, in vitro aortic endothelial‐independent relaxation was enhanced with both α‐tocopherol and mixed‐tocopherol (P < 0.05), while mixed‐tocopherol enhanced aortic contraction at noradrenaline concentrations of 3 × 10−7 M to 3 × 10−5 M (P < 0.05), when compared to normal chow. Supplementation with α‐ and mixed‐tocopherol reduced systemic concentrations of IL‐6 (P < 0.001 and P < 0.001, respectively) and IL‐10 (P < 0.05 and P < 0.001, respectively), while α‐tocopherol also reduced MCP‐1 (P < 0.05) and tumor necrosis factor (TNF)‐α (P < 0.05). Aortic sinus plaque area was significantly reduced with α‐tocopherol supplementation when compared to normal chow (P < 0.01). Conclusion Tocopherol supplementation favorably influenced vascular function and cytokine profile, while it was also effective in reducing atherosclerosis in the apolipoprotein E−/− mouse with CKD.

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“…We found a total of eight studies fitting the search criteria. They included two grape-based studies (Niagara grape extract with vitamin E and grape powder polyphenols) [133,134], one red wine grape pomace (the remnants from juicing grapes for wine) study [135], one dealcoholized-red and white wine study [136], a yellow rice wine study (the phenolic composition of yellow rice is comparable to red wine and is therefore included in this section) [137], and three pomegranate [138][139][140] studies fitting the search criteria. These eight studies implemented different methods of supplementation; further differences are presented in Supplementary Table S1.…”

Section: Grapes and Pomegranatementioning

confidence: 99%

“…The yellow rice wine was studied in LDLR −/− mice, and the red wine pomace was given to SR-B1 KO/ApoER61 h/h mice, which is a model of lethal ischemic heart disease [137]. Red wine grape pomace and Niagara grape extract with α-tocopherol (vitamin E) were looked at in males and females [133,135]. Two of the studies did not disclose the sex of the mice used [134,140].…”

Section: Grapes and Pomegranatementioning

confidence: 99%

The Impact of Dietary Supplementation of Whole Foods and Polyphenols on Atherosclerosis

et al. 2020

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The purpose of this review is to highlight current research on the benefits of supplementation with foods with a diverse polyphenol composition, including fruits, vegetables, nuts, grains, oils, spices, and teas in blunting atherosclerosis. We searched PubMed for publications utilizing whole food or polyphenols prepared from whole foods in Apolipoprotein E (ApoE) or Low-Density Lipoprotein Receptor (LDLR) knockout mice, and identified 73 studies in which plaque was measured. The majority of the studies reported a reduction in plaque. Nine interventions showed no effect, while three using Agaricus blazei mushroom, HYJA-ri-4 rice variety, and safrole-2’, 3’-oxide (SFO) increased plaque. The mechanisms by which atherosclerosis was reduced include improved lipid profile, antioxidant status, and cholesterol clearance, and reduced inflammation. Importantly, not all dietary interventions that reduce plaque showed an improvement in lipid profile. Additionally, we found that, out of 73 studies, only 9 used female mice and only 6 compared both sexes. Only one study compared the two models (LDLR vs. ApoE), showing that the treatment worked in one but not the other. Not all supplementations work in both male and female animals, suggesting that increasing the variety of foods with different polyphenol compositions may be more effective in mitigating atherosclerosis.

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Grape extract and α-Tocopherol effect in cardiovascular disease model of Apo E -/- Mice

Abstract: A synergistic effect between the polyphenols and α-tocopherol was observed, resulting in diminished evolution of atherosclerosis and a greater beneficial effect on atherosclerosis than the isolated consumption of antioxidants.

Cited by 11 publications

References 36 publications

Polyphenol compounds in the chicken/animal diet: from the past to the future

Polyphenol compounds in the chicken/animal diet: from the past to the future

Effect of Tocopherol on Atherosclerosis, Vascular Function, and Inflammation in Apolipoprotein E Knockout Mice with Subtotal Nephrectomy

The Impact of Dietary Supplementation of Whole Foods and Polyphenols on Atherosclerosis

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