Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice

Abstract

Purpose: To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice. Methods: Fifty (n=50) mice were divided into five groups: in group I azoxymethane (AOM) was administered, in Group II -β-lapachone, in group III -vehicle (diluent) and in group IV -vehicle + AOM and finally in group V -β-lapachone + AOM. Results: It was observed the presence of aberrant crypt foci in all animals of groups I and IV, 50% in group II and 90% in group V. Conclusion: The β-lapachone extracted from the Tabebuia avellanedae showed no protective effect of lesions induced by azoxymethane in colon of mice. Key words: Carcinogens. Colorectal Neoplasms. Azoxymethane. Tabebuia. Naphthoquinones. Mice. RESUMOObjetivo: Estudar a ação antitumoral da Tabebuia avellanedae (Ipê-Roxo) na carcinogênese colônica induzida experimentalmente pelo azoximetano em camundongos. Métodos: Foram utilizados 50 camundongos divididos em 5 grupos: grupo I administrado Azoximetano (AOM); grupo II -β-lapachona; grupo III -veículo (diluente); grupo IV -veículo + AOM; e grupo V -β-lapachona + AOM. Resultados: Observou-se presença de focos de criptas aberrantes em todos os animais dos grupos I e IV, 50% no grupo II e 90% no grupo V. Conclusão: A β-lapachona extraída da Tabebuia avellanedae não apresentou efeito protetor das lesões induzidas pelo azoximetano em cólon de camundongos. Descritores: Carcinógenos. Neoplasias Colorretais. Azoximetano. Ipê-Roxo. Naftoquinonas. Camundongos. -Acta Cirúrgica Brasileira -Vol. 26 (2) 2011Aydos RD et al.

Iridoid Glycosides from Tabebuia avellanedae

“…Rescently, various fractions obtained from T . avellanedae and were reported to display antinociceptive, antiedematogenic, astringent, anti‐inflammatory, antibacterial, antifungal, diuretic, anticoagulational, anticancer, regulating immune, laxative and anti‐ulcerogenic properties . A number of compounds identified in the hot H 2 O extract include naphthoquinones, furanonaphthoquinones, anthraquinones, benzoic acid derivatives, benzaldehyde derivatives, iridoids, coumarins, and flavonoids .…”