Studies of distribution and recurrence of Helicobacter spp. gastric mucosa of dogs after triple therapy

Anacleto, Thiago Pires; Lopes, Luiz Roberto; Andreollo, Nelson Adami; Filho, Walter Octaviano Bernis; Resck, Maria Cristina Costa; Macedo, Adriano

doi:10.1590/s0102-86502011000200002

Cited by 15 publications

(9 citation statements)

References 23 publications

(30 reference statements)

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“…Although, a previous study has shown that triple therapy for seven days using clarithromycin, amoxicillin and lansoprazole was effective in 100% of dogs (Anacleto et al 2011), in human medicine, therapies of shorter duration are no longer recommended since it has been demonstrated that a 14-day triple therapy has an approximately 12% better cure rate than a 7-day therapy (Vilaichone et al 2006). Our study confirms this finding in dogs.…”

Section: Discussionsupporting

confidence: 83%

Eradication of gastric Helicobacter spp. by triple therapy in dogs

Mirzaeian¹,

Sarchahi²,

Tabrizi³

et al. 2013

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to determine the efficacy of a triple anti-Helicobacter therapy using omeprazole, amoxicillin and clarithromycin (OAC) in dogs. A total of 15 healthy adult stray dogs with naturally acquired Helicobacter infection were evaluated using polymerase chain reaction and rapid urease test. Subsequently, they received a 21-day triple regimen. One day after the discontinuation of treatment, a second molecular analysis of gastric biopsies revealed complete eradication of Helicobacter DNA with negative quantitative urease testing in all 15 dogs. Our results confirmed the high prevalence of gastric Helicobacter-like organisms (GHLOs) in the stray dog population of Shiraz, Iran, and the effectiveness of our therapeutic regimen for the complete eradication of these microorganisms in stray dogs. In conclusion, for the complete elimination of non-pylori Helicobacter spp. from the gastric mucosa of dogs, a 21-day three-drug regimen with omeprazole, amoxicillin and clarithromycin is suggested.

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Section: Discussionsupporting

confidence: 83%

Eradication of gastric Helicobacter spp. by triple therapy in dogs

Mirzaeian¹,

Sarchahi²,

Tabrizi³

et al. 2013

Vet. Med. - Czech

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“…In dogs, while many studies reported that the fundus and body present higher bacteria density and higher probability to find Helicobacter spp. [8,49,50] others found no significant differences between the density of NHPH in the fundus, body and antrum [31,[51][52][53][54]. The discrepancies in the results regarding the spatial distribution of Helicobacter spp.…”

Section: Discussionmentioning

confidence: 93%

A comparison ofHelicobacter pyloriand non‐Helicobacter pylori Helicobacterspp. Binding to Canine Gastric Mucosa with Defined Gastric Glycophenotype

et al. 2014

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The canine gastric mucosa showed a glycosylation profile different from the human gastric mucosa suggesting that alternative glycan receptors may be involved in Helicobacter spp. binding. Helicobacter pylori and NHPH strains differ in their ability to adhere to canine gastric mucosa. Among the NHPH, H. heilmannii s.s. presented the highest adhesion capacity in agreement with its reported colonization of the canine stomach.

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“…Replacing sucralfate with famotidine, omeprazole, or bismuth subsalicylate may also be effective (Marks, 1997;Jenkins and Bassett, 1997;DeNovo and Magne, 1995). Recurrence rates within 60 days of treatment can be as high as 80% (Anacleto et al, 2011). Treatment of enterohepatic helicobacters may depend on species susceptibility.…”

Section: E Helicobacteriosismentioning

confidence: 99%