Correlation of β-catenin expresssion and metastasis in tongue squamous cell carcinoma

Freitas, Roseana de Almeida; Silveira, Éricka Janine Dantas da; Silveira, João Paulo Borges da; Silva, Fabyanne Mazutti da; Amorim, Rivadávio Fernandes Batista de

doi:10.1590/s0102-86502010000600010

Cited by 11 publications

(8 citation statements)

References 16 publications

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“…Some studies have focussed on the invasive tumour front [33,38] while other studies have examined expression in random areas [24,36,37,39] within the tumour. It would, however, appear from the results in the present study and other studies on OSCC [16,17,25,27,28,35,36,39] that E-cadherin and β-catenin are probably not the key determinants for regional metastases in OSCC.…”

Section: Discussioncontrasting

confidence: 81%

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Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases

et al. 2014

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BackgroundDespite great improvement in the surgical treatment and adjunctive therapy for oral squamous cell carcinoma (OSCC), prognosis remains dismal in advanced cases. Regional metastatic disease is known to reduce recurrence free survival and disease specific survival significantly. The present study was conducted to evaluate the role of cell adhesion molecules β-catenin, E-cadherin and vimentin in predicting tumour metastasis of OSCC.MethodsA total of sixty cases of oral squamous cell carcinoma were included for the study which comprised of 30 cases with lymph node metastases and 30 cases without metastases. Immunohistochemistry was performed for β-catenin, E-cadherin and vimentin on both the test groups along with 30 controls from normal buccal mucosa and inflammatory lesions each.ResultsThere was no significant difference between the immunoreactivity for β-catenin, E-cadherin and vimentin between OSCC with and without lymph node metastases. Vimentin immunopositivity was noted with varying intensity in all cases of OSCC.ConclusionsE-cadherin and β-catenin are probably not the key determinants for regional metastases in OSCC. The role of vimentin expression in OSCC and metastases is controversial and needs to be studied further.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6506095201182002.

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Section: Discussioncontrasting

confidence: 81%

“…Reduced β-catenin staining was a predictive marker for lymph node metastases in OSCC according to few studies [24,33,34] and not by others [16,27,35]. The present study did not have a significant difference in the reduced expression of β-catenin and lymph node metastases in OSCC.…”

Section: Discussioncontrasting

confidence: 76%

Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases

et al. 2014

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“…However, they have found that loss of expression of β -catenin has an association with lower degree of differentiation. Another study using 24 OSCCs showed that there is no difference between the expression of β -catenin in metastatic and nonmetastatic groups through nonparametric Mann-Whitney U test for exploratory descriptive analysis [ 58 ]. Contrasting to these outcomes, Tanaka et al [ 16 ] have found significantly greater reduction in expression level of β -catenin in the lymph node metastatic group ( n = 64) compared to the nonmetastatic group ( n = 95) ( p = 0.001) in a study on 159 OSCC samples, using Kaplan-Meier method log-rank test for statistical analysis.…”

Section: Discussionmentioning

confidence: 99%

Impact of Histological and Molecular Parameters on Prognosis of Oral Squamous Cell Carcinoma: Analysis of 290 Cases

Siriwardena

Karunathilaka

Kumarasiri

et al. 2020

BioMed Research International

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Background. Nodal metastasis is a critical factor in predicting the prognosis of oral squamous cell carcinoma (OSCC). When patients present with a clinically positive neck, the treatment of choice is radical neck dissection. However, management of a clinically negative neck is still a subject of significant controversy. Aim. This study was carried out in order to propose a model to predict regional lymph node metastasis of OSCC using histological parameters such as tumour stage, tumour size, pattern of invasion (POI), differentiation of tumour, and host immune response, together with the expression levels of six biomarkers (periostin, HIF-1α, MMP-9, β-catenin, VEGF-C, and EGFR), and, furthermore, to compare the impact of all these parameters on recurrence and 3 yr and 5 yr survival rates. Materials and Method. Histological materials collected from the archives were used to evaluate histological parameters and immunohistochemical profiles. Standard methods were used for immunohistochemistry and for evaluation of results. Data related to recurrence and survival (3 and 5 years) was also recorded. Clinical data was collected from patients’ records. Results. Male to female ratio was 3 : 1. The commonest site of OSCC was the buccal mucosa, and majority of them were T3 or T4 tumours presented at stage 4. 62.5% of the tumours were well differentiated. Three-year and 5-year survival rates were significantly associated with lymph node metastasis and recurrence. POI was significantly correlated with tumour size, stage, 3-year survival, EGFR, HIF-1α, periostin, and MMP-9 ( p < 0.05 ). Expression of EGFR showed a direct association with metastasis ( p < 0.05 ). Conclusion. POI, level of differentiation, and expression of EGFR are independent prognostic markers for lymph node metastasis. Therefore, these parameters may help in treatment planning of a clinically negative neck.

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“…[ 19 22 ] Many researchers also found a decreased β-Catenin expression in OSCC. [ 19 20 21 22 23 24 25 26 27 28 29 30 31 32 ] When we evaluated β-Catenin expression in normal mucosa and various grades of SCC, there was an obvious decrease in expression noticed in WDSCC and MDSCC. But in PDSCC, the β-Catenin expression was quite comparable with normal oral mucosa without any statistically significant difference.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Expression of the Epithelial to Mesenchymal Transition Proteins E-Cadherin and β-Catenin in Grades of Oral Squamous Cell Carcinoma

Kumar¹,

Panda²,

Dash³

et al. 2021

Journal of Pharmacy and Bioallied Sciences

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Background: E-Cadherin/β-Catenin protein complexes play a major role in epithelial to mesenchymal transition (EMT) and vice versa. Such types of EMT are implicated physiologically during embryonic development and pathologically in tissue fibrosis and tumorigenesis. Aims: The aim was the evaluation of E-Cadherin and β-Catenin immunoreactivity in various grades of oral squamous cell carcinoma (OSCC) and to correlate their pattern of expression. Materials and Methods: Immunohistochemical expression of E-Cadherin/β-Catenin was evaluated in a total n = 30 tissue samples comprising of n = 10 well-differentiated squamous cell carcinoma (WDSCC), n = 10 moderately differentiated squamous cell carcinoma (MDSCC), and n = 10 poorly differentiated squamous cell carcinoma (PDSCC). Based on the intensity of staining, an immunoreactivity scoring was calculated. Statistical Analysis: The scorings obtained were subjected to independent t -test, paired t -test, Chi-square test, and ANOVA test using SPSS version 20.0 statistical analysis software. P < 0.05 was considered statistically significant. Results: A significant difference was observed in the expression of β-Catenin between normal mucosa and WDSCC; normal mucosa and MDSCC. A gradual decrease in the immunoreactivity score of E-Cadherin is seen in WDSCC, MDSCC, and PDSCC. Conclusion: Therefore, dysregulation of these proteins can lead to tumor progression, invasion, and metastasis. Further studies are warranted to specify the role of these EMT proteins as prognostic/therapeutic markers in patients suffering from OSCC.

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Correlation of β-catenin expresssion and metastasis in tongue squamous cell carcinoma

Cited by 11 publications

References 16 publications

Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases

Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases

Impact of Histological and Molecular Parameters on Prognosis of Oral Squamous Cell Carcinoma: Analysis of 290 Cases

Immunohistochemical Expression of the Epithelial to Mesenchymal Transition Proteins E-Cadherin and β-Catenin in Grades of Oral Squamous Cell Carcinoma

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