2010
DOI: 10.1590/s0102-86502010000500010
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Abstract: Purpose:To evaluate the effects of capsaicin on the viability of ischemic random-pattern skin flaps in rats. Methods: Forty EPM1-Wistar rats were randomized into two groups of 20 animals each, the capsaicin group and the control group. A random-pattern skin flap measuring 10 x 4cm was raised and a plastic barrier was placed between the flap and the donor site. After the surgical procedure, the control group was treated with an inert vehicle in the form of a cream applied uniformly to a rayon bandage which, in … Show more

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Cited by 10 publications
(8 citation statements)
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“…9 When a random skin flap is raised, injury to the blood vessels causes hemodynamic instability, leading to blood flow abnormality, which causes the most common complication of flap surgery, partial flap necrosis. 10 The distal portion of a local random pattern skin flap has the maximum risk of ischemic necrosis because of decreased vascular perfusion. The most effective way to prevent this undesirable complication is to provide adequate nutritive blood flow in the microcirculation.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…9 When a random skin flap is raised, injury to the blood vessels causes hemodynamic instability, leading to blood flow abnormality, which causes the most common complication of flap surgery, partial flap necrosis. 10 The distal portion of a local random pattern skin flap has the maximum risk of ischemic necrosis because of decreased vascular perfusion. The most effective way to prevent this undesirable complication is to provide adequate nutritive blood flow in the microcirculation.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have been conducted to improve flap viability by using various agents to increase blood supply or neovascularization. 10 Our study scrutinized skin needling as an alternative treatment to increase skin flap survival. Although the skin needling procedure is used in cosmetic surgery widely, there is no published study that shows its effect on flap survival.…”
Section: Discussionmentioning
confidence: 99%
“…Skin flap viability was evaluated by measuring the surviving flap area using a transparent graph paper. The percentage of flap viability was simply calculated using the following formula: Percentage = (surviving tissue area/total flap area) × 100 .…”
Section: Methodsmentioning
confidence: 99%
“…Numerous experimental studies have been performed to increase flap viability, using different pharmacological agents such as nebivolol , sildenafil , taurin and capsaicin with promising results. Carnitine is one of these agents increasing flap viability .…”
Section: Introductionmentioning
confidence: 99%
“…It activates the mast cells 6 , increases the production of histamine, leukotrienes and tumor necrosis factor-alpha (TNF-alpha); it also activates the endothelial cells 7,8 In contrast, the action of CGRP is slower, steadily progressive and of longer duration, inducing an intensive vasodilatation 10,11 . As an a proinflammatory, CGRP is capable of activating mast cells, macrophages, fibroblasts, melanocytes, keratinocytes, dendritic cells and lymphocytes B and T, promoting the development of edema induced by IL-1 and IL-8, and is chemotactic to neutrophiles.…”
Section: Introductionmentioning
confidence: 99%