2010
DOI: 10.1590/s0102-86502010000500009
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Abstract: Purpose:To qualify the FT-Raman spectral data of primary and metastatic cutaneous melanoma in order to obtain a differential diagnosis. Methods: Ten normal human skin samples without any clinical or histopathological alterations, ten cutaneous melanoma fragments, and nine lymph node metastasis samples were used; 105, 140 and 126 spectra were obtained respectively. Each sample was divided into 2 or 3 fragments of approximately 2 mm 3 and positioned in the Raman spectrometer sample holder in order to obtain the … Show more

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Cited by 16 publications
(10 citation statements)
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“…Our results show only a slight increase in the 1360-1400 cm À1 , but a considerable increase in Raman intensity in the 1475-1640 cm À1 range for MM and PN, which was also reported elsewhere for MM (49). Additionally, a decrease in the 1450 cm À1 band could be identified for PN, as has been similarly reported (51).…”
Section: Visual Inspection Of Mean Spectrasupporting
confidence: 90%
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“…Our results show only a slight increase in the 1360-1400 cm À1 , but a considerable increase in Raman intensity in the 1475-1640 cm À1 range for MM and PN, which was also reported elsewhere for MM (49). Additionally, a decrease in the 1450 cm À1 band could be identified for PN, as has been similarly reported (51).…”
Section: Visual Inspection Of Mean Spectrasupporting
confidence: 90%
“…Additionally, a decrease in the 1450 cm À1 band could be identified for PN, as has been similarly reported (51). A decrease in the 936 cm À1 band that has been reported for BCC and SCC (1) or BCC and MM (22,48,49) could be identified in MM and PN in our results (Figs S1-S4).…”
Section: Visual Inspection Of Mean Spectrasupporting
confidence: 90%
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“…The frequency shift of the light is equal to the frequency of the molecular vibration. 19 Fourthly, primary tumours were compared between patients who went on to develop metastasis with those who did not. This won C.V. Raman the Nobel prize in 1930.…”
Section: Introductionmentioning
confidence: 99%
“…It has been reported that the sensitivity and specificity of using Raman spectrometry to diagnose gastric mucosal lesions in vivo are 85%–95% and 90%–98%, respectively [13]. Scientists now mainly focus on the differential comparison of Raman spectra, the establishment of diagnostic models and principles by combining Raman spectrometry and multivariate statistics, and distinguishing malignant versus benign tumors, pathological subtypes, degree of differentiation, and lymph node metastasis [1], [4][7], [10]. Raman spectrometry has not been utilized to its full potential to analyze the microstructure of molecules and the mechanisms and principles associated with malignancy of tissue and cells.…”
Section: Introductionmentioning
confidence: 99%