Effect of sirolimus on renal injury induced by bile duct ligation in rats

Öztürk, Hülya; Terzi, Akan; Öztürk, Hayrettin; Kükner, Aysel

doi:10.1590/s0102-86502010000500004

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…The presence of biliary obstruction was an independent predictor of postoperative AKI according to the authors’ results, and the mechanism by which bilirubin may be toxic to the kidneys seems to be inflammatory as well as obstructive[35], and hemodynamic changes may also play a role in biliary cast nephropathy[36]. In addition to the aforementioned effects, patients who are candidates for surgery in the presence of biliary obstruction with congestive cholestasis in the liver[37,38] may undergo major hepatic resections, with consequent decrease in the volume of a functionally deficient liver parenchyma, predisposing for PHLF.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for acute kidney injury after partial hepatectomy

Bredt¹,

Peres²

2017

WJH

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AIMTo identify risk factors for the occurrence of acute kidney injury (AKI) in the postoperative period of partial hepatectomies.METHODSRetrospective analysis of 446 consecutive resections in 405 patients, analyzing clinical characteristics, preoperative laboratory data, intraoperative data, and postoperative laboratory data and clinical evolution. Adopting the International Club of Ascites criteria for the definition of AKI, potential predictors of AKI by logistic regression were identified.RESULTSOf the total 446 partial liver resections, postoperative AKI occurred in 80 cases (17.9%). Identified predictors of AKI were: Non-dialytic chronic kidney injury (CKI), biliary obstruction, the Model for End-Stage Liver Disease (MELD) score, the extent of hepatic resection, the occurrence of intraoperative hemodynamic instability, post-hepatectomy haemorrhage, and postoperative sepsis.CONCLUSIONThe MELD score, the presence of non-dialytic CKI and biliary obstruction in the preoperative period, and perioperative hemodynamics instability, bleeding, and sepsis are risk factors for the occurrence of AKI in patients that underwent partial hepatectomy.

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Section: Discussionmentioning

confidence: 99%

Risk factors for acute kidney injury after partial hepatectomy

Bredt¹,

Peres²

2017

WJH

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“…Nazar et al found that, in AKI in hepatic failure, terlipressin was effective in only 13% of patients with serum bilirubin >10 mg/dL compared with 67% of patients with lower bilirubin [ 16 ]. The nephrotoxic mechanism appears to be inflammatory as it is attenuated by the use of sirolimus [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction

Alnasrallah

Collins

Zwi

2016

Case Reports in Nephrology

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Kidney injury in the context of cholestatic liver dysfunction is not uncommon; this has been historically referred to as cholemic nephrosis implying a direct deleterious renal effect of cholemia. However, scepticism about the exact role that bile and its constituents play in this injury has led to the disappearance of the term. We describe a case of severe AKI due to bile nephropathy with bile casts in flucloxacillin-induced liver dysfunction. We also discuss the recent literature reviving the concept of bile nephropathy.

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“…The mechanism by which bilirubin may be toxic to the kidneys seems to be also inflammatory, besides obstructive, as described by Ozturk et al Through administration of sirolimus in animals submitted to BDL, they demonstrated that the drug decreased tubulointerstitial inflammation in the kidney induced by BDL [ 14 ]. As a consequence, sirolimus provided (or led to a protection) a protection effect against the BDL-induced AKI.…”

Section: Evidence Of Biliary Salt-induced Akimentioning

confidence: 99%

Do Biliary Salts Have Role on Acute Kidney Injury Development?

Romano

Vieira

2015

J Clin Med Res

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Acute kidney injury (AKI) is a major complication in patients with acute liver failure and chronic liver disease. Hemodynamic changes appear to be the principal alterations in these conditions, therefore there should be no known structural abnormalities responsible for AKI. On the other hand, several authors have published data on structural changes known as bile cast nephropathy or cholemic nephrosis, which basically consist of the presence of bile casts in tubular lumen analogous to those observed in myeloma. Although these findings are well documented, there is a lack of reproducibility by other authors. This paper aims to discuss, through evidence-based medical literature, the role of biliary salts on kidney injury development.

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Effect of sirolimus on renal injury induced by bile duct ligation in rats

Cited by 4 publications

References 32 publications

Risk factors for acute kidney injury after partial hepatectomy

Risk factors for acute kidney injury after partial hepatectomy

Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction

Do Biliary Salts Have Role on Acute Kidney Injury Development?

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