The effect of prophylactic dose of a low molecular weight heparin on skin wound healing of rats

Abstract

Purpose:To investigate the effect of prophylactic dose of a low molecular weight heparin, enoxaparin, on skin wound healing of rats. Methods: Forty rats were used for the study. Rats were randomly assigned to two equal groups. Experimental group received prophylactic dose of enoxaparin. Physiologic saline was administered to the control group. Parameters of wound healing of experimental and control groups were compared. For comparison of the groups in terms of fibrosis, vascularization, inflammation, epithelization, and tensile strength test (Newton). Mann-Whitney-U test was used because variables were categorical data (fibrosis, vascularization, inflammation and epithelization). Differences between groups were analyzed with independent samples t-test (tensile strength). Significance was set at p<0.05. Results: Skin wound of the experimental group presented tensile strength significantly decreased (p<0.001), histopathologic examination revealed a significant (p<0.001) delayed epithelization and decreased in fibrosis, vascularization, inflammation (p<0.001) in the experimental group. Conclusion: Enoxaparin delay wound healing by decreased inflammatory cells, fibroblast contents and their products (growth factors), and by promoted hemorrhage.

Effects of apixaban, rivaroxaban, dabigatran and enoxaparin on histopathology and laboratory parameters in Achilles tendon injury: An in vivo study

“…Oken et al . [ 16 ] also reported that factor Xa inhibitor enoxaparin, a LMWH species, decreased vascularity formation, inflammation, fibrosis and delayed epithelization in tissue healing model, similar to our study. In the LMWH (nadroparin) group used by Eren et al .,[ 6 ] type I collagen amount is higher and tendon healing is faster.…”

Pathogenesis of wound healing disorders in the elderly

“…Cytotoxic antineoplastic agents (e. g. hydroxyurea, tyrosine kinase inhibitors, angiogenesis inhibitors [ 108,109 ] Systemic corticosteroids [ 110 ] Systemic nonsteroidal antiinflammatory drugs (NSAIDs) (e. g. ibuprofen, acetylsalicylic acid [111][112][113] ) Anticoagulants [ 114 ] Bisphosphonates [ 115 ] Morphine [ 116 ] microenvironment -the interactions between the various cell types and proteases involved -it is not surprising that the outcomes of using these factors in the treatment of chronic wounds have not been fully satisfactory. Further research is definitely required to uncover strategies that will improve their clinical effectiveness.…”

“…Darüber hinaus sollten differenzialdiagnostisch auch verschiedene Autoimmunerkrankungen wie Vaskulitis (Abbildung 6 ) und rheumatoide Arthritis [ 73 ] sowie Stoffwechselerkrankungen wie Calciphylaxie [ 74 ] [ 110 ] Systemische nichtsteroidale Antiphlogistika (NSAP) (z. B. Ibuprofen, Acetylsalicylsäure [111][112][113] ) Antikoagulanzien [ 114 ] Bisphosphonate [ 115 ] Morphine [ 116 ] Abbildung 7 Prätibiale Pyoderma gangraenosum, die sich als schmerzhafte entzündliche Läsion mit Blasenbildung und zentraler nekrotischer Ulzeration präsentiert.…”

Direct-Acting Oral Anticoagulants (DOACs) in Cirrhosis and Cirrhosis-Associated Portal Vein Thrombosis

“…39 Like thrombin, inhibition of factor Xa has also been linked to decreased fibrosis formation in the skin, but at the cost of decreased wound healing. 41 While most factors in the coagulation cascade are reduced in end-stage liver disease, von Willebrand factor (VWF) is increased. 1 Higher levels of VWF are correlated with portal hypertension, hepatic decompensations, and death.…”