Influence of omentoplasty on colonic anastomosis in animals submitted to hemorrhagic shock in rats

Bolzam-Nascimento, Ricardo; Coy, Cláudio Saddy Rodrigues; Pereira, Yara Ematne Amaral; Leal, Raquel Franco; Reis, Rosana Celestina Morandin; Mantovani, Mário; Ayrizono, Maria de Lourdes Setsuko; Chung, Wu Feng; Fagundes, João José

doi:10.1590/s0102-86502009000300013

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…As the surgical techniques and the suture materials, other factors interfere in anastomosis quality, as antibiotics 4,5 , antioxidants 6,7 , antineoplasics 8 , imunossupressors 9 , hormones 10 , trauma 11 , shock [12][13][14] , adherences 15,16 and ischemia 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric oxygen therapy and mechanical resistence of the colonics anastomosis in rats with peritonitis

et al. 2010

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Purpose:To analyze the effects of hyperbaric oxygen therapy (HBO) on the mechanical resistance of anastomosis performed in rats' distal colon presenting peritonitis induced by ligature and cecal punction using the Total Energy Rupture biomechanical test (ETR). Methods: It was used 45 rats divided into three groups of 15 animals each. In Control Group (CG), it was performed anastomosis in distal colon without peritonitis. In Peritonitis Group (PG), it was performed anastomosis six hours after the induction of peritonitis by ligature and cecal punction. In Hyperbaric Chamber Group (HCG), it was performed six hours after the induction of peritonitis by ligature and cecal punction. The animals on CG and PG were kept at place air while the animals on HCG were placed on an experimental hyperbaric chamber in order to inhale oxygen at 100%, two absolute atmospheres, for 120 minutes, for four consecutive days. Euthanasia took place on the fifth day of the experiment. All the animals underwent to Total Energy Rupture Biomechanical Resistance test (ETR). Total Energy Rupture was defined as the necessary internal energy stored up to promote the colon rupture after an external traction force imposition. Results: The Peritonitis Group presents smaller average ETR than Control Group. There was no statistical difference between Peritonitis Group and Hyberbaric Chamber Group. Conclusion: Hyperbaric oxygen therapy did not alter the mechanical resistance of anastomosis performed in distal colon of rats under the presence of peritonitis induced by ligature and cecal puncture. Key words: Anastomosis, Surgical. Colon. Hyperbaric Oxygenation. Peritonitis. Rats. RESUMO Objetivo:Analisar o efeito da oxigenoterapia hiperbárica (HBO) sobre a resistência mecânica de anastomoses realizadas em cólon distal de ratos na presença de peritonite induzida por ligadura e punção cecal utilizando o teste biomecânico de Energia Total de Ruptura (ETR). Métodos: Foram utilizados 45 ratos distribuídos em três grupos de 15 animais. No Grupo Controle (GC), realizou-se anastomose no cólon distal sem peritonite. No Grupo Peritonite (GP), realizou-se anastomose seis horas após a indução da peritonite por ligadura e punção cecal. No Grupo Câmara Hiperbárica (GCH), realizou-se anastomose seis horas após a indução da peritonite por ligadura e punção cecal. Os animais dos GC e GP foram mantidos em ar ambiente. Os animais do GCH foram colocados em uma câmara hiperbárica experimental para inalarem oxigênio a 100%, a duas atmosferas absolutas, durante 120 minutos, por quatro dias consecutivos. A eutanásia ocorreu no quinto dia do experimento. Todos os animais foram submetidos ao Teste de Resistência Biomecânico Energia Total de Ruptura (ETR). A Energia Total de Ruptura foi definida como a energia interna acumulada necessária para promover o rompimento do cólon após a imposição de uma força externa de tração. Resultados: O Grupo Peritonite apresentou menor média de ETR que o Grupo Controle. Não houve diferença estatística entre o Grupo Peritonite e o Grupo C...

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Section: Introductionmentioning

confidence: 99%

Hyperbaric oxygen therapy and mechanical resistence of the colonics anastomosis in rats with peritonitis

et al. 2010

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“…However, there are both local and systemic factors that interfere in the healing process of intestinal anastomoses, related to the surgical technique, the use of pharmacological agents and general conditions of the patient, among which are included immunosuppression, infection, uremia, poor nutrition, anemia, elderly and anastomosis' vascularization [4][5][6] . The reduced blood flow as a result of shock is a leading cause of failure in the healing of intestinal anastomosis, once the healing process is directly related to perfusion in the suture line 9 .…”

Section: Introductionmentioning

confidence: 99%

Effect of hemorrhagic shock on intestinal anastomoses’ healing

Oliveira¹,

Cabral²,

Silva³

et al. 2015

J Surg Clin Res

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Background/Purpose: Hypovolemia and shock is increasingly frequent in the perioperative of intestinal anastomoses, especially due to abdominal trauma. The aim of this study is to evaluate the effects of hemorrhagic shock in the healing of intestinal anastomoses in rats. Methods: It was analyzed the shock interference on the strength of ileum anastomoses. Histologically, structural changes of the anastomotic segments were assessed by two pathologists. Data are given as mean ± SEM. The animals were randomly selected and assigned in two groups with six rats each: Group 1-rats with hypovolemic shock (shocked+enterectomy) treated with fresh whole blood. Group 2-rats not shocked, untreated + enterectomy. Results: The intestinal anastomosis bursting pressure of shock+enterectomy group rats was lower than in the unshocked+enterectomy group, and the difference was significant (p=0.001). In the hemorrhagic shock+enterectomy group rats the density of collagen and fibrous tissue was lower and inflammation/foreign body reaction was higher than in the unshocked+enterectomy group, featuring a more immature and deficient healing. Conclusion: In conclusion, the results show that the hypovolemic shock affects the ileum wound healing, causing a decrease in the bursting pressure (mmHg) of ileal anastomosis, leading to the fragility of the surgical wound.

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Impact of omentoplasty on anastomotic leak and septic complications after low pelvic anastomosis: a study from the NSQIP database

Ozben

Özüner

Işık

et al. 2018

Int J Colorectal Dis

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Influence of omentoplasty on colonic anastomosis in animals submitted to hemorrhagic shock in rats

Cited by 4 publications

References 18 publications

Hyperbaric oxygen therapy and mechanical resistence of the colonics anastomosis in rats with peritonitis

Hyperbaric oxygen therapy and mechanical resistence of the colonics anastomosis in rats with peritonitis

Effect of hemorrhagic shock on intestinal anastomoses’ healing

Impact of omentoplasty on anastomotic leak and septic complications after low pelvic anastomosis: a study from the NSQIP database

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