2009
DOI: 10.1590/s0102-86502009000300004
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Abstract: Purpose:To evaluate the inhibitory effect of vitamin C on the experimental esophageal carcinogenesis induced by diethylnitrosamine (NDEA). Methods: Sixty Wistar male rats aged three months, with mean weight of 210 g were employed in the study and were divided into four different groups according to the drinking drugs: group I -controls: only water, seven days a week; group II -only vitamin C, seven days a week; group III -NDEA, three days a week and water during the other four days; group IV -NDEA, three days … Show more

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Cited by 8 publications
(8 citation statements)
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“…Vitamin C can enhance the body's resistance to number of diseases, including infectious disorders and many types of cancer [31,32]. Supplementation of vitamin C was found to improve components of the human immune system such as antimicrobial and natural killer cell activities, lymphocyte proliferation, chemotaxis, and delayed-type hypersensitivity [33].…”
Section: Discussionmentioning
confidence: 99%
“…Vitamin C can enhance the body's resistance to number of diseases, including infectious disorders and many types of cancer [31,32]. Supplementation of vitamin C was found to improve components of the human immune system such as antimicrobial and natural killer cell activities, lymphocyte proliferation, chemotaxis, and delayed-type hypersensitivity [33].…”
Section: Discussionmentioning
confidence: 99%
“…They demonstrated that the 300 mol/L is the ideal concentration of ascorbic acid to inhibit nitrosation, which occurs in humans with a daily oral ingestion of 200 mg of vitamin C. The Committee on Diet, Nutrition, and Cancer of the National Academy of Sciences showed in 1982, that the vitamin C inhibits the formation of some carcinogens and also the consumption of foods rich in vitamin C would be associated with low risk of esophageal carcinoma [15]. There are many soundings about recommended allowable values of vitamin C. Authors, such as Levine et al [23] suggest a daily ingestion of 100 -120 mg/ day, through the daily consumption 5 portions of fruits and vegetables, and a maximum of 1 g/day, as a safe measure to avoid adverse effects of excessive Ingestion [24]. In our study, the mean intake of vitamin C was 109 mg/day for the cases and 142 mg/day for the controls which is more than RDA (Recommended Dietary Allowances).…”
Section: Discussionmentioning
confidence: 99%
“…In the United States of America it can be used only as a mixture with salt (sodium chloride) containing a maximum of 0.6% sodium nitrite 11,15,25,26 .…”
Section: Discussionmentioning
confidence: 99%