2009
DOI: 10.1590/s0102-86502009000300002
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Abstract: Purpose:To study the effects of benzodiazepine midazolam in the coronary flow (Cflo), cardiac frequency (CF) and myocardial contractility in isolated hearts of rats subjected to ischemic preconditioning (IPC). Methods: 30 Wistar rats were used, undistinguished by gender. After anesthesia with ethyl ether, the hearts were put into perfusion (Krebs-Henseleit solution, 95% O 2 and 5% CO 2 , 37°C, 110-120mmHg), in disposable Langendorff type system. Five groups of six animals were constituted: GI-Control; GII-Isch… Show more

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Cited by 4 publications
(4 citation statements)
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“…These results associate the benefits of omeprazole with the results reported by studies addressing myocardial protection with ischemic preconditioning [8,[25][26][27][28]. The pharmacokinetics basis may be related to changes in transmembrane H + /K + gradients, the first markers of myocardial ischemia, responsible for the repolarization expressed in T-wave morphology of the electrocardiogram [29].…”
Section: Discussionsupporting
confidence: 64%
“…These results associate the benefits of omeprazole with the results reported by studies addressing myocardial protection with ischemic preconditioning [8,[25][26][27][28]. The pharmacokinetics basis may be related to changes in transmembrane H + /K + gradients, the first markers of myocardial ischemia, responsible for the repolarization expressed in T-wave morphology of the electrocardiogram [29].…”
Section: Discussionsupporting
confidence: 64%
“…These results associate the benefits of omeprazole with the results reported by studies addressing myocardial protection with ischemic preconditioning [11][12][13][14][15]. The pharmacokinetics basis may GOMES, OM ET AL -Proteção da recuperação funcional do miocárdio pelo omeprazol após isquemia-reperfusão em corações isolados de ratos…”
Section: Discussionunclassified
“…This research resulted in multicenter studies involving the so-called drugs amiloride and cariporida (channel blocking Na + / H + ), which confirmed good protection of cardiomyocytes. These good results can be associated with studies using ischemic preconditioning and also the benefits from the use of omeprazole, an inhibitor pump H + /K + ATPase initially used for reduction of gastric hyperacidity [8,[17][18][19][20]. The explanation for the action of omeprazole in the myocardium may be related with the changes of transmembrane H + /K + and flags of ischemic electrocardiographic tracings which action is expressed in the morphological changes of the T wave [21].…”
Section: Discussionmentioning
confidence: 99%