2009
DOI: 10.1590/s0102-86502009000100008
| View full text |Cite
|
Sign up to set email alerts
|

Abstract: Purpose: To assessment of the aspartate aminotransferase (AST), creatine kinase (CK) and creatine kinase isoenzyme fraction MB (CK-MB) serum activity in female dogs anesthetized with ketamine S (+), atropine and xylazine in several associations. Methods: Twenty three healthy female dogs randomly distributed in four groups named as GI (n=6), GII (n=6), GIII (n=6) and GIV (n=5) were treated respectively with atropine and ketamine S(+) (0.04mg/kg; 10 mg/kg); ketamine S(+) (10 mg/kg); atropine, xylazine and ketami… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

1
5
0

Year Published

2012
2012
2018
2018

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 11 publications
(6 citation statements)
references
References 18 publications
1
5
0
Order By: Relevance
“…All post-heat concentrations of troponin fell in the concentration range that is associated with the lowest risk of mortality (Antman et al 1996), but the small change in young monkeys does suggest a low level of myocardial damage. Increases in troponin have also been reported as a normal response to repeated ketamine sedation, and we observed 9 of 13 animals increasing troponin concentrations over the experimental period which consisted of 10 sedations (Franco et al 2009). Young animals have the ability to increase heart rate more than old animals, and a small amount of tachycardia related-damage with heat stress is a possible explanation for the greater levels of post-treatment troponin in this age group.…”
Section: Discussionsupporting
confidence: 65%
See 1 more Smart Citation
“…All post-heat concentrations of troponin fell in the concentration range that is associated with the lowest risk of mortality (Antman et al 1996), but the small change in young monkeys does suggest a low level of myocardial damage. Increases in troponin have also been reported as a normal response to repeated ketamine sedation, and we observed 9 of 13 animals increasing troponin concentrations over the experimental period which consisted of 10 sedations (Franco et al 2009). Young animals have the ability to increase heart rate more than old animals, and a small amount of tachycardia related-damage with heat stress is a possible explanation for the greater levels of post-treatment troponin in this age group.…”
Section: Discussionsupporting
confidence: 65%
“…This control group showed some biological changes over the 5-week study, particularly fasting glucose, that are relevant to the interpretation of study results. Monkeys required sedation twice weekly and for assessments which can be associated with some changes in cardiac biomarkers (Franco et al 2009). Additionally, our control group remained thermoneutral under sedation, but without exposure to hydrostatic pressure which may have independent effects on cardiac health (Epstein 1992).…”
Section: Discussionmentioning
confidence: 99%
“…A high level of troponin may result from increased permeability of the myocytes or degradation of native troponin into smaller fragments due to ischemia (36). Franco et al reported that changes in creatine kinase isoenzyme fraction MB (CK-MB) serum activity observed in dogs treated with atropine, xylazine and ketamine S(+) were higher than the baseline values 6 h after the experiment (37). These data indicate that there is likely to be a definite change in cTnI levels.…”
Section: Discussionmentioning
confidence: 99%
“…Although the indication of α 2 -adrenoceptor antagonists, pre-anesthetic drugs, is limited due to adverse effects observed mainly in combinations with α 2 -adrenoceptor agonists (FRANCO et al, 2009), they can be useful in situations involving potentially dangerous wild animals that do not allow good pre-anesthesia assessment. In the present study, the addition of the anticholinergic agent may have reduced sialorrhea, which made oral examination and dental procedures safer, and corroborates other veterinary dental research that used this combination (BENGAZI et al, 2013;CESARETTI et al, 2018;NESGASH et al, 2016).…”
Section: Discussionmentioning
confidence: 99%