2008
DOI: 10.1590/s0102-86502008000300003
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Abstract: PURPOSE: To elaborate an animal model with the objective of studying the continence of the biological valves surgically performed in the left colon of rats. METHODS: Thirty four rats were operated on and divided into three groups (G). G1 (sham) animals which underwent laparotomy only; G2 (perineal amputation without valves): animals which underwent amputation of the anal sphincter complex combined with a perineal colostomy; G3 (abdominoperineal amputation combined with valves): animals which underwent abdomino… Show more

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Cited by 3 publications
(4 citation statements)
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References 6 publications
(5 reference statements)
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“…Clinical, radiological, histopathological and immunohistochemical analysis raised the possibility that the section of the muscle layer, accompanied by section of plexus of Auerbach, undermine the impulse propagation by surgical denervation. Morphology, distension of the colon and histological features, for the presence of fibrosis at the site of seromiotomy, confirmed that the partial stenosis obtained with sutures and its effects are responsible for the intraluminar contention 25 mechanism 6 , 20 , 5 , 18 .…”
Section: Discussionmentioning
confidence: 61%
“…Clinical, radiological, histopathological and immunohistochemical analysis raised the possibility that the section of the muscle layer, accompanied by section of plexus of Auerbach, undermine the impulse propagation by surgical denervation. Morphology, distension of the colon and histological features, for the presence of fibrosis at the site of seromiotomy, confirmed that the partial stenosis obtained with sutures and its effects are responsible for the intraluminar contention 25 mechanism 6 , 20 , 5 , 18 .…”
Section: Discussionmentioning
confidence: 61%
“…The seromyotomy undertaken in the valve construction results in local denervation [4][5][6]13 . In this denervated segment, there To extrapolate the current findings to human beings, we conclude with future perspectives of more studies that consider the systematic analysis of other elements, such as interstitial cells of Cajal, neurotransmitters and the physiology of the operated segment, submucosal plexus of Meissner and colonic mucosa 16 .…”
Section: Discussionmentioning
confidence: 99%
“…This procedure involves the section of the myenteric plexus (Auerbach's) with the preservation of the submucosal plexus (Meissner's) and mucosal plexus, thus resulting in localized surgical de-enervation. The histological alterations in the valves constructed at the cellular and neural levels remain unknown [4][5][6] .…”
Section: Introductionmentioning
confidence: 99%
“…Aiming to solve the problem in a more physiological way, seromyotomies have been proposed for the preparation of this patient, following the principles proposed by Lázaro da Silva (1991) in the making of perineal colostomy 15 . This procedure results in slight fibrotic ring without stenosis of the gut lumen, but a braking mechanism that is responsible for the continence 2,5,6,11,14 . The follow-up period of 34 months showed a patient psychologically better, maintaining treatment for alcoholism without relapsing, without diarrhea, evacuating from four to a maximum of six times per day without dermatitis, with improvement of chronic anal fissures, reinserted in the social context and and reaching a lifestyle closer to normal.…”
Section: Discussionmentioning
confidence: 99%