Rapid restoration of colonic goblet cells induced by a hydrolyzed diet containing probiotics in experimental malnutrition

Dock-Nascimento, Diana Borges; Junqueira, Kelly; Aguilar-Nascimento, José Eduardo de

doi:10.1590/s0102-86502007000700014

Cited by 21 publications

(15 citation statements)

References 22 publications

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“…Study on the organ mass also showed decreased weight in malnourished and malnourished mice infected with Giardia. Interestingly, after nourishing such malnourished mice with protein diet, the body mass, blood parameters and mass of all the pivotal organs were improved [23,30].…”

Section: Discussionmentioning

confidence: 99%

Effect of Giardia duodenalis in protein malnourished and renourished mice

Shukla

Sidhu

2011

Open Medicine

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AbstractThe present study was designed to delineate the effect of Giardia duodenalis in malnourished and renourished BALB/c mice. Control and renourished mice were fed with a standard pellet diet while malnourished mice were fed with a low protein (4.3 %) diet both before and after being challenged orally with actively growing G. duodenalis trophozoites. It was observed that malnourished mice had a greater severity and longer duration of Giardia infection compared with renourished mice. These malnourished mice also had less body mass but higher cyst and trophozoite counts. Malnourished mice infected with Giardia had significantly decreased level of total serum proteins, albumin, globulins, hemoglobin, leukocyte, and differential leukocyte counts compared with renourished mice. From the data it is concluded that protein malnutrition profoundly affects the anthropometric and physiological parameters of the body indicating greater susceptibility and severity of the disease.

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Section: Discussionmentioning

confidence: 99%

Effect of Giardia duodenalis in protein malnourished and renourished mice

Shukla

Sidhu

2011

Open Medicine

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“…Malnutrition per se can also increase lamina propria populations of macrophages and lymphocytes along with increased proinflammatory cytokines, which may further alter intestinal barrier function 118,129 . In addition, malnutrition may compromise innate immune barriers, Paneth cell defensins, and goblet cell mucins, the last having been shown to be ameliorated by probiotic interventions 146 …”

Section: Evidence From Animal Models Showing That Infections Cause Grmentioning

confidence: 99%

Malnutrition as an enteric infectious disease with long-term effects on child development

et al. 2008

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Malnutrition is a major contributor to mortality and is increasingly recognized as a cause of, potentially lifelong, functional disability. Yet, a rate-limiting step in achieving normal nutrition may be impaired absorptive function due to multiple repeated enteric infections. This is especially problematic in children whose diets are marginal. In malnourished individuals, the infections are even more devastating. This review documents the evidence that intestinal infections lead to malnutrition and that malnutrition worsens intestinal infections. The clinical data presented here derive largely from long-term cohort studies that are supported by controlled animal studies. Also reviewed are the mechanisms by which enteric infections lead to undernutrition and by which malnutrition worsens enteric infections, with implications for potential novel interventions. Further intervention studies are needed to document the relevance of these mechanisms and, most importantly, to interrupt the vicious diarrhea-malnutrition cycle so children may develop their full potential.

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“…For instance, the administration of a multi-strain probiotic preparation containing L. helveticus strain LAT 179 to broiler chickens caused an increase in body weight and serum albumin levels, an increase in serum levels of minerals (i.e., calcium and potassium), a decrease in triglyceride levels and an improved antioxidant status (Capcarova et al, 2011). In another study, the administration of an aproteic diet with L. helveticus Bionan (Nestlé, Brazil) in combination with S. thermophilus protected the colonic mucosa of mice by counteracting the effect of malnutrition and restoring the number of goblet cells (Dock-Nascimento et al, 2007). Analogously, the same probiotic preparation administered to mice in pre- and post-operative periods stimulated the immune system, increased the production of serum IgA and increased colonic weight (Aguilar-Nascimento et al, 2006).…”

Section: Other Proposed Health-promoting Properties Of L Helveticusmentioning

confidence: 99%

Health-Promoting Properties of Lactobacillus helveticus

Taverniti¹,

Guglielmetti²

2012

Front. Microbio.

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Lactobacillus helveticus is an important industrial thermophilic starter that is predominantly employed in the fermentation of milk for the manufacture of several cheeses. In addition to its technological importance, a growing body of scientific evidence shows that strains belonging to the L. helveticus species have health-promoting properties. In this review, we synthesize the results of numerous primary literature papers concerning the ability of L. helveticus strains to positively influence human health. Several in vitro studies showed that L. helveticus possesses many common probiotic properties, such as the ability to survive gastrointestinal transit, adhere to epithelial cells, and antagonize pathogens. In vivo studies in murine models showed that L. helveticus could prevent gastrointestinal infections, enhance protection against pathogens, modulate host immune responses, and affect the composition of the intestinal microbiota. Interventional studies and clinical trials have also demonstrated a number of health-promoting properties of L. helveticus. Finally, several studies suggested that specific enzymatic activities of L. helveticus could indirectly benefit the human host by enhancing the bioavailability of nutrients, removing allergens and other undesired molecules from food, and producing bioactive peptides through the digestion of food proteins. In conclusion, this review demonstrates that in light of the scientific literature presented, L. helveticus can be included among the bacterial species that are generally considered to be probiotic.

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Rapid restoration of colonic goblet cells induced by a hydrolyzed diet containing probiotics in experimental malnutrition

Abstract: Streptococcus thermophilus and Lactobacillus helveticus added to a renutrition diet enhance the recovery of mucosal atrophy induced by malnutrition and especially induce a rapid restoration of goblet cells population in the malnourished colonic mucosa.

Cited by 21 publications

References 22 publications

Effect of Giardia duodenalis in protein malnourished and renourished mice

Effect of Giardia duodenalis in protein malnourished and renourished mice

Malnutrition as an enteric infectious disease with long-term effects on child development

Health-Promoting Properties of Lactobacillus helveticus

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