Effects of budesonide and probiotics enemas on the systemic inflammatory response of rats with experimental colitis

Abstract

Probiotics are effective to diminished inflammatory status mediated by IL-6 in experimental colitis.

Effect of Lactobacillus casei on the Production of Pro-Inflammatory Markers in Streptozotocin-Induced Diabetic Rats

“…Several earlier studies have shown the possible potential of probiotics as anti-inflammatory agents by decreasing cytokine responses [25,26,32,33]. Moreover, their antiinflammatory effect has also been demonstrated in IBD patients [16].…”

Probiotics prevent growth deficit of colon wall strata of malnourished rats post-lactation

“…Probiotics are able to stimulate the immunological system (Erickson and Hubbard 2000, Cano and Perdigón 2003, Copolla and Gil Turnes 2004, Villena et al 2006, De Souza et al 2007, Dewan et al 2007, kaburagi et al 2007, Pitsouni et al 2009) it is suggested that the deficit prevention in the tissue formation of the mucosa due to malnourishment be balanced because of the proliferation of conjunctive tissue cells (the lamina propria), which explains the results observed in animals of G4. Besides, the height G1: commercial chow for rodents; G2: commercial chow + supplementation with probiotics; G3: chow with 4% proteins; G4: chow with 4% proteins + supplementation with probiotics.…”

“…These findings ratify the beneficial effect of the intake of these microorganisms, including in cases when the amount of proteins present in the provided diet does not meet the demand of the involved organism. Possibly, the increase of the intestinal barrier efficiency (Menningen and Bruewer 2009) and the stimulation of the immunological system (Erickson and Hubbard 2000, Cano and Perdigón 2003, Copolla and Turnes 2004, Villena et al 2006, De Souza et al 2007, Dewan et al 2007, kaburagi et al 2007, Pitsouni et al 2009) promoted by the action of probiotics must have collaborated to a higher absorption of available aminoacids in the hypoproteic feed. Studies on this hypothesis can corroborate future investigations that aim to optimize the access to functional foods or supplements containing probiotics in cases of malnourishment in humans.…”

“…Several studies have demonstrated that probiotics estimulate cell proliferation of the immune system associated to the intestinal mucosa (Erickson and Hubbard 2000, Cano and Perdigón 2003, Villena et al 2006, De Souza et al 2007, Dewan et al 2007, kaburagi et al 2007, Pitsouni et al 2009), which may contribute to the control of infections, as well as to their prevention in the case of diseases derived from nutritional deficiency. On the other hand, there are few studies that evaluated the action of probiotics on the intestinal morphology of malnourished animals, and were mostly restricted only to the study of the mucosa (Allori et al 2000, Cano et al 2002, Dock et al 2004a, b, Dock-Nascimento et al 2007.…”

Clinical Observation of a Novel, Complementary, Immunotherapeutic Approach based on Ketogenic Diet, Chondroitin Sulfate, Vitamin D₃, Oleic Acid and a Fermented Milk and Colostrum Product

“…Thus, it is well known that probiotics administered by enemas reduce the inflammatory status in experimental colitis (Souza et al, 2007) and rectal administration of lactobacilli in children with active distal ulcerative colitis effective in reducing mucosal inflammation and changing mucosal expression levels of cytokines involved in the mechanisms of inflammatory bowel disease (Oliva et al, 2011). In addition, it has been recently demonstrated that the offlabel use of milk and molasses enemas is safe and effective in treating constipation with negligible side effects (Vilke at al., 2015).…”