2007
DOI: 10.1590/s0102-86502007000700008
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Abstract: PURPOSE: The aim of this study was to investigate whether the hind limbs or intestinal tract is the most important initiator of the inflammatory response secondary aortic clamping and hind limb ischemia/reperfusion injury. METHODS: Blood samples of Wistar rats obtained from posterior cava vein, portal vein, and heart cavity during either laparotomy (control group, n=8) or laparotomy + 2 h of aortic clamping and bilateral hind limb ischemia (ischemia group, n=8), or 2 h after ischemia and 2 h of reperfusion (is… Show more

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Cited by 8 publications
(5 citation statements)
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“…Table S6 in Additional file 6 summarizes the mechanistic studies of mediators in animal models [ 124 170 ]. Thirty-nine of the 47 studies used rodents to develop abdominal sepsis models (i.e., cecum ligation and puncture (CLP)) [ 124 , 125 , 127 , 128 , 131 133 , 136 138 , 143 , 145 , 151 , 154 , 156 , 157 , 159 , 162 , 164 , 165 , 167 170 ], or shock-resuscitation, or abdominal compartment syndrome (ACS), or two-hit models [ 126 , 130 , 132 , 135 140 , 142 , 144 , 146 150 , 152 , 160 162 , 166 ]. The remaining utilized swine [ 129 , 134 , 155 , 158 , 163 ], baboons [ 141 ], or dogs [ 153 ].…”
Section: Resultsmentioning
confidence: 99%
“…Table S6 in Additional file 6 summarizes the mechanistic studies of mediators in animal models [ 124 170 ]. Thirty-nine of the 47 studies used rodents to develop abdominal sepsis models (i.e., cecum ligation and puncture (CLP)) [ 124 , 125 , 127 , 128 , 131 133 , 136 138 , 143 , 145 , 151 , 154 , 156 , 157 , 159 , 162 , 164 , 165 , 167 170 ], or shock-resuscitation, or abdominal compartment syndrome (ACS), or two-hit models [ 126 , 130 , 132 , 135 140 , 142 , 144 , 146 150 , 152 , 160 162 , 166 ]. The remaining utilized swine [ 129 , 134 , 155 , 158 , 163 ], baboons [ 141 ], or dogs [ 153 ].…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, IL-1 primarily serves a role in chemoattraction, macrophage stimulation and increase of downstream cell and chemical factors. IL-6 is also involved in systemic immune responses and inflammatory cascades, and can activate neutrophils to exacerbate the production of inflammatory mediators after trauma, effectively enhancing the severity of tissue injury (30). MPO is produced by polymorphonuclear leukocytes, and the levels of active MPO reflect the activation of polymorphonuclear leukocytes in the lungs (31).…”
Section: Discussionmentioning
confidence: 99%
“…Although reperfusion is essential for the survival of ischemic tissue, there is good evidence that reperfusion itself causes additional cellular injury. Renal ischemia-reperfusion (I/R) injury is caused by multiple mechanisms involving tubular cell apoptosis, oxygen free radical formation, mitochondrial dysfunction, inflammatory cytokine generation, and neutrophil sequestration [3][4][5]. I/R injury is closely associated with acute renal injury leading to increased acute rejection and unacceptable high mortality of patients [6].…”
Section: Introductionmentioning
confidence: 99%