Considerations that may influence the result of trials assessing tensile strength in experimental surgery

Rossi, Lucas Félix; Ramos, Renata Ribeiro; Ely, Jorge Bins; Kestering, Darlan de Medeiros; Soldi, Marly da Silveira; Brum, Sandro Polidoro Berni; d'Acâmpora, Armando José

doi:10.1590/s0102-86502007000600015

Cited by 9 publications

(5 citation statements)

References 2 publications

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“…Among these parameters, measurement of tensile strength is particularly relevant in cases of intervention through the abdominal wall, because tensile strength testing provides accurate and prompt results and reflects the reality of clinical practice, in which a pulling force is exerted on the surgical wound whenever patients contract their abdomen 9,11,13 . reflect interference in some stage of the wound healing process.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effects of carbon dioxide pneumoperitoneum on abdominal wall wound healing in rats undergoing segmental resection and anastomosis of the left colon

Morais¹,

Farias²,

Duraes³

et al. 2012

Acta Cir. Bras.

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PURPOSE: To evaluate the influence of carbon dioxide pneumoperitoneum on abdominal wall wound healing in rats. METHODS: Eighty rats underwent laparotomy, segmental left colon resection, and anastomosis. The animals were divided into three experimental groups and one control group: EI = pneumoperitoneum for 30 minutes before laparotomy (n=20); EII = pneumoperitoneum for 30 minutes after abdominal closure (n=20); EIII = pneumoperitoneum for 30 minutes before laparotomy and 30 minutes after abdominal closure (n=20); C = control group, without pneumoperitoneum (n=20). In each group, 10 animals were killed 7 days and 10 animals 14 days postoperatively. A segment of the abdominal wall was resected and subjected to tensile strength testing. Another segment of abdominal muscle was used for histopathological analysis; the specimens were fixed in formalin and stained with hematoxylin and eosin. RESULTS: There were no differences in histopathology and tensile strength values among animals in the experimental and control groups 7 or 14 days after surgery. CONCLUSION: Under the present experimental conditions, carbon dioxide pneumoperitoneum did not interfere with abdominal wall wound healing.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the effects of carbon dioxide pneumoperitoneum on abdominal wall wound healing in rats undergoing segmental resection and anastomosis of the left colon

Morais¹,

Farias²,

Duraes³

et al. 2012

Acta Cir. Bras.

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“…The breaking strength of the anastomosis provides rapid, accurate and reproducible results 36 . In this study, no significant differences between groups were found, but the values in group III (pneumoperitoneum before laparotomy and after laparorrhaphy)…”

Section: Histopathologymentioning

confidence: 99%

The effect of carbon dioxide pneumoperitoneum on the healing colonic anastomosis in rats

et al. 2013

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“…This method of measuring tensile strength provides accurate results, but it is dependent on correct and precise fixation of the anastomosis. 8 All the anastomoses were performed in the same exact location with at least 3 cm of tissue in each side of the anastomotic line (base of the penis and prostate) to allow precise fixation. The custom-designed cryogrip clamps have been previously used by our group for fixation of soft tissues, and the cryogrip clamps demonstrated the most consistent way to measure soft tissue mechanics by the consistent indentations of the grip to the tissue after finalization of testing.…”

Section: Discussionmentioning

confidence: 99%

“…The tensile strength was recorded with a computerized mechanical testing machine. This method of measuring tensile strength provides accurate results, but it is dependent on correct and precise fixation of the anastomosis 8 . All the anastomoses were performed in the same exact location with at least 3 cm of tissue in each side of the anastomotic line (base of the penis and prostate) to allow precise fixation.…”

Section: Discussionmentioning

confidence: 99%

Penile urethral resection and anastomosis augmentation with regional tissue tension relieving technique: A cadaveric mechanical study and clinical outcome in two dogs

et al. 2021

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Objective: To describe penile urethral augmentation anastomosis (PURAA) for resection anastomosis (RA) of the canine penile urethra by using autogenous tissue in two dogs and to determine the mechanical properties of the augmentation technique in cadaveric specimens.Study design: Cadaveric study and two case reports. Animals: Sixteen canine cadavers and two dogs with urethral obstruction.Methods: The lower urogenital system was harvested from cadavers and randomized into two groups: simple (S) and augmented (AUG) RA of the urethra. Tensile strength and peak load were compared between the two groups. Two dogs were treated with PURAA for urethral obstruction secondary to juxtaurethral neoplasms.Results: Minimal tensile strength (MITS) and maximal tensile strength (MATS) were greater in the AUG group (MITS, 54.36 ± 24.0 N; MATS, 75.37 ± 34.79 N) compared with the S group (MITS, 11.78 ± 4.93 N, P = .0014; MATS, 13.74 ± 3.89 N, P = .0015). Both dogs recovered without complications. Histopathological examinations were consistent with a lipomatous mass in both cases. Both dogs had good medium-to-long-term outcomes. Conclusion:The augmentation technique improved the tensile properties of penile RA in normal cadavers and was associated with successful outcomes in two dogs.Clinical significance: Penile urethral augmentation anastomosis may help prevent stricture or leakage secondary to tension at the surgical site after penile urethral RA.

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Considerations that may influence the result of trials assessing tensile strength in experimental surgery

Cited by 9 publications

References 2 publications

Evaluation of the effects of carbon dioxide pneumoperitoneum on abdominal wall wound healing in rats undergoing segmental resection and anastomosis of the left colon

Evaluation of the effects of carbon dioxide pneumoperitoneum on abdominal wall wound healing in rats undergoing segmental resection and anastomosis of the left colon

The effect of carbon dioxide pneumoperitoneum on the healing colonic anastomosis in rats

Penile urethral resection and anastomosis augmentation with regional tissue tension relieving technique: A cadaveric mechanical study and clinical outcome in two dogs

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