Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats&lt;A NAME="volta1"&gt;&lt;/A&gt;

Neves, José de Souza; Aguilar-Nascimento, José Eduardo de; Gomes-da-Silva, Maria Helena Gaíva; Cavalcanti, Rosecélia Nunes; Bicudo, Alberto Salomão; Nochi, Rubens Jardim

doi:10.1590/s0102-86502006001000002

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…When used as a supplement to PN, glutamine counteracts PN‐induced intestinal atrophy and improves parameters of postresection adaptation 62 – 65 . In contrast, glutamine added to chow or an elemental diet has no effect on or decreases measures of structural or functional intestinal adaptation 66 – 69 . It is likely that any modest effects of glutamine are masked by the greater trophic stimulation provided by luminal nutrition in these studies.…”

Section: Physiological Features Of Intestinal Adaptationmentioning

confidence: 83%

“…[62][63][64][65] In contrast, glutamine added to chow or an elemental diet has no effect on or decreases measures of structural or functional intestinal adaptation. [66][67][68][69] It is likely that any modest effects of glutamine are masked by the greater trophic stimulation provided by luminal nutrition in these studies. No studies assessing the effect of glutamine alone on intestinal adaptation have been conducted in humans with SBS, but glutamine in combination with growth hormone (GH) has shown some efficacy (see below).…”

Section: Key Factors In Intestinal Adaptationmentioning

confidence: 99%

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Intestinal Adaptation Following Resection

Tappenden

2014

J Parenter Enteral Nutr

208

175

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Intestinal adaptation is a natural compensatory process that occurs following extensive intestinal resection, whereby structural and functional changes in the intestine improve nutrient and fluid absorption in the remnant bowel. In animal studies, postresection structural adaptations include bowel lengthening and thickening and increases in villus height and crypt depth. Functional changes include increased nutrient transporter expression, accelerated crypt cell differentiation, and slowed transit time. In adult humans, data regarding adaptive changes are sparse, and the mechanisms underlying intestinal adaptation remain to be fully elucidated. Several factors influence the degree of intestinal adaptation that occurs post resection, including site and extent of resection, luminal stimulation with enteral nutrients, and intestinotrophic factors. Two intestinotrophic growth factors, the glucagon-like peptide 2 analog teduglutide and recombinant growth hormone (somatropin), are now approved for clinical use in patients with short bowel syndrome (SBS). Both agents enhance fluid absorption and decrease requirements for parenteral nutrition (PN) and/or intravenous fluid. Intestinal adaptation has been thought to be limited to the first 1-2 years following resection in humans. However, recent data suggest that a significant proportion of adult patients with SBS can achieve enteral autonomy, even after many years of PN dependence, particularly with trophic stimulation.

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Section: Physiological Features Of Intestinal Adaptationmentioning

confidence: 83%

Section: Key Factors In Intestinal Adaptationmentioning

confidence: 99%

Intestinal Adaptation Following Resection

Tappenden

2014

J Parenter Enteral Nutr

208

175

View full text Add to dashboard Cite

show abstract

“…Both drugs and nutrients have been used to stimulate cell growth and proliferation in SBS, namely, insulin (27), growth hormone and glucagon‐like peptide‐2 (28,29), glutamine, arginine, zinc, and, more recently, lactoferrin (30–32). The 3D model provides a tool to investigate the type and amount of fuel necessary to optimize absorptive changes and promote intestinal sufficiency.…”

Section: Discussionmentioning

confidence: 99%