Avaliação do extrato de Aroeira (Schinus terebinthifolius Raddi) no processo de cicatrização de gastrorrafias em ratos

Santos, Orlando José dos; Filho, Jurandir Marcondes Ribas; Czeczko, Nicolau Gregori; Neto, Manoel Lages Castelo Branco; Naufel, Carlos Roberto; Ferreira, Lydia Masako; Campos, Rodrigo Peixoto; Moreira, Hamílton; Porcides, Rafael D.; Dobrowolski, Samuel

doi:10.1590/s0102-86502006000800007

Cited by 20 publications

(12 citation statements)

References 4 publications

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“…It has been used in folk medicine as teas, infusions or tinctures as an anti-inflammatory, febrifuge, analgesic, and depurative agent; also, it has been used to treat skin wounds, repair injury in respiratory, digestive and genitourinary systems [1][2][3][4][5][6] . Previous reports have demonstrated that S. terebinthifolius extracts or fractions is rich in polyphenols, which display antioxidant, antibacterial, antifungal and anti-allergic activities in different experimental models [7][8] .…”

Section: ■ Introductionmentioning

confidence: 99%

Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

et al. 2017

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Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuatesinflammatory responses in cutaneous wound healing in mice 1 AbstractPurpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods:The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/ vaseline base), or STRO-treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure rate; the inflammation was evaluated by leukocytes accumulation and cytokine levels in the wounds. The accumulation of neutrophil and macrophages in the wounds were determined by assaying myeloperoxidase and N-acetyl-β-D-glucosaminidase activities. The levels of TNF-α, CXCL-1 and CCL-2 in wound were evaluated by ELISA assay. Angiogenesis and collagen fibers deposition were evaluated histologically. Results:We observed that macroscopic wound closure rate was improved in wounds from STRO-group than Control-group. The wounds treated with STRO promoted a reduction in leucocyte accumulation and in pro-inflammatory cytokine. Moreover, STRO treatment increased significantly the number of blood vessels and collagen fibers deposition, as compared to control group. Conclusion: Topical application of STRO display anti-inflammatory and angiogenic effects, as well as improvement in collagen replacement, suggesting a putative use of this herb for the development of phytomedicines to treat inflammatory diseases, including wound healing.

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Section: ■ Introductionmentioning

confidence: 99%

Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

et al. 2017

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“…Its use is mentioned against inflammatory diseases, infectious diseases, antimicrobial properties, anti-ulcerogenic and in gastritis. These presents astringent activities, tonic, haemostatic, anti-neuralgic, mutagenic effects, antioxidants and healing 4,6,10,26,27,28,29,30,34 . The Carapa guianensis Aublet, Meliaceae family, was first described by French botanist Jean-Baptiste Christopher Fusee Aublet in 1775 in French Guiana.…”

Section: Introductionmentioning

confidence: 99%

Efeito de Schinus terebinthifolius Raddi (aroeira) e Carapa guianensis Aublet (andiroba) na cicatrização de gastrorrafias

Santos

Malafaia

Ribas-Filho

et al. 2013

ABCD, arq. bras. cir. dig.

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-Background -The gastrorraphy isolated or associated with the use of biological adhesives formed throughout the history of surgery the usual way to promote healing in gastric lesions; however, the use of herbal medicine has been increasingly employed to help the wound healing. Aim -To evaluate the wound healing caused in the stomach of rats using extract of Schinus terebinthifolius Raddi and Carapa guianensis Aublet oil. Methods -Ninety rats, adult males were divided into three groups: aroeira, andiroba and control group, which were subdivided into three subgroups of five animals according to the time of the deaths (seven, 14 and 21 days). All underwent the same surgical procedure (injury and suture the stomach) differing only to the animals in groups aroeira and andiroba that received a daily dose of 100 mg / kg of hydroalcoholic extract and oil, by gavage, while the control group received normal saline. The parameters evaluated were the macroscopic and microscopic test of resistance to air insufflation and test the traction force.Results -All animals showed good healing of gastric and abdominal wall without infection and dehiscence. Both groups presented neighboring organs adhesions on the gastric surface. The endurance test for air insufflation showed higher average pressure within seven days and the test revealed greater traction force of rupture between seven and 14 days in groups aroeira and andiroba. The intensity of chronic inflammation revealed statistically significant differences in angiogenesis and fibroblast proliferation. Conclusion -The use of extract of Schinus terebinthifolius Raddi and Carapa guianensis Aublet oil favored the gastric wound healing in rats.RESUMO -Racional -A gastrorrafia isolada ou associada ao uso de adesivos biológicos constituiu ao longo da história da cirurgia a forma usual de promover a cicatrização nas lesões gástricas; entretanto, o uso de fitoterápico tem sido cada vez mais empregado para auxiliar o processo cicatrical. Objetivo -Avaliar a cicatrização de ferida provocada no estômago de ratos com uso do extrato hidroalcoólico de Schinus terebinthifolius Raddi e óleo da Carapa guianensis Aublet. Métodos -Foram utilizados 90 ratos, adultos, machos, distribuídos em três grupos: grupo aroeira, grupo controle e grupo andiroba, os quais foram subdivididos em três subgrupos de cinco animais conforme o momento da morte induzida (sete, 14 e 21 dias). Todos foram submetidos ao mesmo procedimento cirúrgico (lesão e rafia do estômago) diferindo apenas que os animais dos grupos aroeira e andiroba receberam dose diária de 100 mg/kg do extrato hidroalcoólico e do óleo, via gavagem, enquanto o grupo controle recebeu solução salina isotônica. Os parâmetros avaliados foram: alterações macroscópicas e microscópicas, teste de resistência à insuflação de ar atmosférico e teste pela força de tração. Resultados -Todos os animais demonstraram boa cicatrização da parede abdominal e das gastrorrafias, sem infecção e deiscência. Ambos os grupos apresentaram aderências à superfície das ga...

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“…On the other hand, chronic inflammation has longer duration and it is histologically associated to the presence of lymphocytes and macrophages, blood vessel proliferation, tissue fibrosis and necrosis. Therefore, we opted to use the very same protocol used for the histological evaluation of the study pieces, excluding the reepitelization, coaptation of suture edges, and wall infiltrate extension items, present in the original protocol 14 .…”

Section: Discussionmentioning

confidence: 99%

Use of 2-octyl cyanoacrylate adhesive in rat liver induced lesion

Santos¹,

Marques²,

Filho³

et al. 2012

Acta Cir. Bras.

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PURPOSE:To evaluate the healing process of rat traumatic liver lesion corrected with the use of 2-octyl cyanoacrylate adhesive, compared to the use of biologically absorbable chromed catgut thread suture. METHODS: Thirty mail adult rats were divided into two groups (15 per group) according to the used method for liver lesion correction as follows: adhesive group (AG), and catgut group (CG); each group being divided into three subsets of five animals (7th, 14th, and 21st day), respectively, according to post-surgery evaluation. All animals were submitted to homogeneous lesion applying synthetic bonding to AG and using chromed catgut suture to CG for lesion correction. Macroscopic and microscopic parameters of healing processes were evaluated. RESULTS: Both groups of animals showed excellent abdominal wall healing, with no evidence of infection, and no abdominal cavity peritonitis or abscess. The presence of adherence was observed in both groups with no statistically significant difference. As to macroscopic evaluation, there was statistically significant difference with respect to specific factors of clinical inflammation (ischemic inflammation and giant celular inflammatory reaction) between animals evaluated on the 10th day (ischemic necrosis and giant celular inflammatory reaction) among animals evaluated on the 14th day (A14 versus C14). CONCLUSION: Applying 2-octyl-cyanoacrylate adhesive for correcting rat liver lesion does not change healing process when compared to the use of chromed catgut stitch. Key words: Wound Healing. Liver. Adhesives. Rats. RESUMO OBJETIVO:Avaliar o processo de cicatrização de lesão induzida em fígado de rato utilizando adesivo de 2-octil cianoacrilato em comparação com a sutura com catgut cromado. MÉTODOS: Utilizou-se 30 ratos adultos, machos, distribuídos em dois grupos de 15 animais denominados de grupo adesivo (GA) e grupo catgut (GC); cada grupo foi dividido em três subgrupos, cada um com cinco animais, de acordo com a data marcada para avaliação pós-operatória (sétimo, décimo quarto e vigésimo primeiro dia). Todos os animais foram submetidos à lesão homogênea, aplicando o adesivo sintético no GA e utilizando sutura com catgut cromado no GC para correção das lesões. Foram avaliados parâmetros de macroscópicos e microscópicos do processo de cicatrização. RESULTADOS: Em ambos os grupos os animais evoluíram com boa cicatrização da parede abdominal, sem evidência clínica de infecção, sem abscessos ou peritonite na cavidade abdominal; a presença de aderências foi observada em ambos os grupos sem diferenças estatisticamente significantes; quanto à avaliação microscópica só houve diferença estatisticamente significante quanto aos parâmetros específicos de inflamação crônica (necrose isquêmica e reação gigantocelular) entre os animais avaliados no décimo quarto dia (A14 vs. C14). CONCLUSÃO: O emprego de adesivo de 2-octil cianoacrilato na correção de lesão em fígado de rato não altera o processo de cicatrização quando comparado ao uso de sutura com fio de categute cromado. Des...

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Avaliação do extrato de Aroeira (Schinus terebinthifolius Raddi) no processo de cicatrização de gastrorrafias em ratos

Cited by 20 publications

References 4 publications

Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

Efeito de Schinus terebinthifolius Raddi (aroeira) e Carapa guianensis Aublet (andiroba) na cicatrização de gastrorrafias

Use of 2-octyl cyanoacrylate adhesive in rat liver induced lesion

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